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Erschienen in: Familial Cancer 2/2013

01.06.2013 | Original Article

Endometrial and ovarian cancer in women with Lynch syndrome: update in screening and prevention

verfasst von: Karen H. Lu, Molly Daniels

Erschienen in: Familial Cancer | Ausgabe 2/2013

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Abstract

Women with Lynch syndrome have an additional need to address the substantial increased lifetime risk of endometrial and ovarian cancer. Endometrial or ovarian cancer can be the presenting cancer in individuals with Lynch syndrome, or can be a second cancer. Lifetime risk of endometrial cancer in women with MLH1 or MSH2 mutations is approximately 40 %, with a median age of 49. Women with MSH6 mutations have a similar risk of endometrial cancer but a later age of diagnosis. Lynch syndrome-associated endometrial cancers are primarily endometrioid, although non-endometrioid subtypes including clear cell, papillary serous and MMMT have been reported. In addition, endometrial cancers arising in the lower uterine segment, while rare in the general population, are enriched in women with Lynch syndrome. Ovarian cancer risk in women with Lynch syndrome is 6–8 %, and Lynch syndrome-associated ovarian cancers exhibit a variety of histopathological subtypes. Studies of endometrial cancer screening in Lynch syndrome have been small, and more recently have focused on the use of office endometrial biopsy to identify pre-malignant and early stage cancers. Prevention options include the use of oral contraceptives, which are known to be highly effective for decreasing risk of both endometrial and ovarian cancer in the general population, and prophylactic surgery to remove the uterus and ovaries.
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Metadaten
Titel
Endometrial and ovarian cancer in women with Lynch syndrome: update in screening and prevention
verfasst von
Karen H. Lu
Molly Daniels
Publikationsdatum
01.06.2013
Verlag
Springer Netherlands
Erschienen in
Familial Cancer / Ausgabe 2/2013
Print ISSN: 1389-9600
Elektronische ISSN: 1573-7292
DOI
https://doi.org/10.1007/s10689-013-9664-5

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