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Familial Cancer

Erschienen in:

01.06.2015 | Review Article

The roles of AXIN2 in tumorigenesis and epigenetic regulation

verfasst von: Shuang Li, Chunpeng Wang, Xiaodong Liu, Shucheng Hua, Xin Liu

Erschienen in: Familial Cancer | Ausgabe 2/2015

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Abstract

AXIN2, an important regulator in Wnt/β-catenin signaling pathway, takes part in regulating cell proliferation, cytometaplasia, migration, apoptosis and other important functions, has showed close relations with the development of liver cancer, colon cancer, lung cancer, breast cancer and so on. The epigenetic regulation provides new insights for further exploring the pathogenesis of tumor. In this paper, the roles of AXIN2 in tumorigenesis, AXIN2 methylation, ubiquitination and siRNA/RNA regulation will be reviewed.

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Titel: The roles of AXIN2 in tumorigenesis and epigenetic regulation
verfasst von: Shuang Li
Chunpeng Wang
Xiaodong Liu
Shucheng Hua
Xin Liu
Publikationsdatum: 01.06.2015
Verlag: Springer Netherlands
Erschienen in: Familial Cancer / Ausgabe 2/2015
Print ISSN: 1389-9600
Elektronische ISSN: 1573-7292
DOI: https://doi.org/10.1007/s10689-014-9775-7

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The roles of AXIN2 in tumorigenesis and epigenetic regulation

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