Introduction
Detection | “Validation” | Relation with prognosis | Pro’s | Cons | |
---|---|---|---|---|---|
Glomerular filtration rate
| |||||
Creatinine | Seruma
| CHF AHF | Strong evidence | Easy Cheap Interpretable | Exponential relationship with GFR Dependent on muscle mass |
(s)MDRD | Serum | CHF Not in AHF | Strong evidence | Valid Accurate | Formula (calculation) Less reliable in extremes of GFR |
BUN | Serum | CHF AHF | Emerging evidence | Easy Cheap | Interpretation difficult |
Cystatin C | Seruma
| CHF AHF | Evidence in AHF | Unbiased Very reliable | Interpretation difficult Costs |
Glomerular permeability
| |||||
Albuminuria | Urine | CHF Not in AHF | Strong evidence CHF | Easy obtainable Cheap Additive to GFR | Low specificity |
Tubulointerstitial damage
| |||||
NAG | Urine | CHF Not in AHF | Emerging evidence CHF | Easy obtainable Additive to GFR and UAE Strong marker of AKI | Low specificity Costs |
KIM-1 | Urine | CHF Not in AHF | Emerging evidence CHF | Easy obtainable Additive to GFR and UAE Strong marker of AKI | Costs |
NGAL | Urine/Serum | CHF AHF | Emerging evidence CHF and AHF | Easy obtainable Additive to GFR and UAE Strong marker of AKI | Low specificity especially in serum and in CHF |
IL-18 | Urine/Serum | CHF Not in AHF | Emerging evidence CHF | Easy obtainable Strong marker of AKI | Also strongly increased in inflammation |
FABP-1 | Urine/Serum | Not in CHF Not in AHF | None | Strong marker of AKI | Elevated in sepsis Also found in liver |
Glomerular filtration rate
Serum creatinine
Estimated GFR, creatinine-based formulas
Blood urea nitrogen (BUN)
Study | Year |
N
| Setting | BUN (mg/dL) | Relative risk for mortality |
---|---|---|---|---|---|
Lee [25] | 2003 | 4031 | ADHF | 29 ± 19 | 1.49 (1.39–1.60) per 10 units increase |
Aronson [19] | 2004 | 541 | ADHF | 34 ± 22 | 2.3 (1.3–4.1) for quartiles |
Heywood [24] | 2005 | 680 | CHF | 29 ± 20 | BUN 30–50: 1.9, BUN >50: 2.2 |
Shenkman [26] | 2007 | 257 | ADHF | 33 ± 22 | 3.6 (1.8–7.3) per log unit increase |
Filippatos [21] | 2007 | 302 | ADHF | 31 ± 17 | 1.03 (1.00–1.05) per unit increase |
Cauthen [20] | 2008 | 444 | CHF | 14 (6–22) | 1.04 (1.03–1.06) per unit increase |
Klein [27] | 2008 | 949 | CHF | 25 (14–41) | 1.11 (1.07–1.15) per 5 units increase |
Lin [22] | 2009 | 243 | CHF | 27 ± 17 | 1.24 (1.02–1.51) for BUN-to-creatinine ratio |
Gotsman [23] | 2010 | 362 | ADHF | 23 (17–29) | 1.80 (1.30–2.49), per tertile BUN/creatinine |