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Erschienen in: Inflammation 2/2012

01.04.2012

Circulating Cytokine Levels in Acute Pancreatitis—Model of SIRS/CARS Can Help in the Clinical Assessment of Disease Severity

verfasst von: Ivan Gunjaca, Josip Zunic, Mihaela Gunjaca, Zdenko Kovac

Erschienen in: Inflammation | Ausgabe 2/2012

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Abstract

The aim of our study was to evaluate the pro- and anti-inflammatory cytokine response during acute pancreatitis and its predictive value on severity of disease. A hospital-based prospective clinical study was conducted. Twenty patients with acute pancreatitis were enrolled during a 12-month period. Plasma concentrations of TNF-α, IL-1β, IL-6, and IL-10 were determined at days 1, 2, 3, 6, and 9. The patient population was analyzed by type of acute pancreatitis. Severity was defined according to the Atlanta criteria for assessing severity of acute pancreatitis. Clinical variables were recorded to patients classified in one of two groups: severe acute pancreatitis (SAP group) and mild acute pancreatitis (MILD group). Patients with SAP had significantly higher average levels of IL-6 compared to the MILD group patients (539.2 pg/L vs. 23.4 pg/L, p < 0.0001). Also, the values of IL-10 were significantly higher in patients with SAP (242.4 pg/L vs. 8.1 pg/L, p = 0.003). The values of TNF-α were not significantly different in both groups. The value of IL-6 and IL-10 showed a positive correlation (r = 0.7964, p < 0.0001). Although a relatively small sample of patients was used, we can conclude that the determination of the value of IL-6 and IL-10 can help in the clinical assessment of disease severity.
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Metadaten
Titel
Circulating Cytokine Levels in Acute Pancreatitis—Model of SIRS/CARS Can Help in the Clinical Assessment of Disease Severity
verfasst von
Ivan Gunjaca
Josip Zunic
Mihaela Gunjaca
Zdenko Kovac
Publikationsdatum
01.04.2012
Verlag
Springer US
Erschienen in
Inflammation / Ausgabe 2/2012
Print ISSN: 0360-3997
Elektronische ISSN: 1573-2576
DOI
https://doi.org/10.1007/s10753-011-9371-z

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