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Inflammation
Erschienen in: Inflammation 1/2016

01.02.2016 | Original Article

Alpha-Lipoic Acid Attenuates Oxidative Damage in Organs After Sepsis

verfasst von: Fabricia Petronilho, Drielly Florentino, Lucinéia Gainski Danielski, Luiz Carlos Vieira, Maryane Modolon Martins, Andriele Vieira, Sandra Bonfante, Mariana Pereira Goldim, Francieli Vuolo

Erschienen in: Inflammation | Ausgabe 1/2016

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Abstract

Sepsis progression is linked with the imbalance between reactive oxygen species and antioxidant enzymes. Thus, the aim of this study was to evaluate the effect of alpha-lipoic acid (ALA), a powerful antioxidant, in organs of rats submitted to sepsis. Male Wistar rats were subjected to sepsis by cecal ligation puncture (CLP) and treated with ALA or vehicle. After CLP (12 and 24 h), the myeloperoxidase (MPO) activity, protein and lipid oxidative damage, and antioxidant enzymes in the liver, kidney, heart, and lung were evaluated. ALA was effective in reducing MPO activity, lipid peroxidation in the liver, and protein carbonylation only in the kidney in 12 h after CLP. In 12 h, SOD activity increased in the kidney and CAT activity in the liver and kidney with ALA treatment. Thus, ALA was able to reduce the inflammation and oxidative stress in the liver and kidney after sepsis in rats.
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Metadaten
Titel
Alpha-Lipoic Acid Attenuates Oxidative Damage in Organs After Sepsis
verfasst von
Fabricia Petronilho
Drielly Florentino
Lucinéia Gainski Danielski
Luiz Carlos Vieira
Maryane Modolon Martins
Andriele Vieira
Sandra Bonfante
Mariana Pereira Goldim
Francieli Vuolo
Publikationsdatum
01.02.2016
Verlag
Springer US
Erschienen in
Inflammation / Ausgabe 1/2016
Print ISSN: 0360-3997
Elektronische ISSN: 1573-2576
DOI
https://doi.org/10.1007/s10753-015-0256-4

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