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Erschienen in: Inflammation 2/2016

09.11.2015 | ORIGINAL ARTICLE

Protective Effects of Growth Arrest-Specific Protein 6 (Gas6) on Sepsis-Induced Acute Kidney Injury

verfasst von: Long-wang Chen, Wei Chen, Zhi-qiang Hu, Jia-lan Bian, Lan Ying, Guang-liang Hong, Qiao-meng Qiu, Guang-ju Zhao, Zhong-qiu Lu

Erschienen in: Inflammation | Ausgabe 2/2016

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Abstract

Acute kidney injury (AKI) is a serious complication of sepsis, which has a high mortality rate. Growth arrest-specific protein 6 (Gas6), the protein product of the growth arrest specific gene 6, has been shown to have an anti-apoptotic effect as well as pro-survival capability. Here, we investigated the effects of Gas6 on sepsis-associated AKI in mice subjected to cecal ligation and puncture (CLP). We found that the administration of rmGas6 significantly reduced serum urea nitrogen and creatinine and improved the survival of septic mice. Furthermore, the renal pathological damage induced by CLP was attenuated by rmGas6 treatment. Finally, rmGas6 reduced the renal tissue apoptotic index and the expression of Bax, while it upregulated the expression of Bcl-2. The data suggest that rmGas6 might be used as a potential therapeutic agent for sepsis-induced AKI.
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Metadaten
Titel
Protective Effects of Growth Arrest-Specific Protein 6 (Gas6) on Sepsis-Induced Acute Kidney Injury
verfasst von
Long-wang Chen
Wei Chen
Zhi-qiang Hu
Jia-lan Bian
Lan Ying
Guang-liang Hong
Qiao-meng Qiu
Guang-ju Zhao
Zhong-qiu Lu
Publikationsdatum
09.11.2015
Verlag
Springer US
Erschienen in
Inflammation / Ausgabe 2/2016
Print ISSN: 0360-3997
Elektronische ISSN: 1573-2576
DOI
https://doi.org/10.1007/s10753-015-0282-2

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