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Erschienen in: International Ophthalmology 2-3/2007

01.06.2007 | Original Paper

The spectrum of Vogt-Koyanagi-Harada disease in South India

verfasst von: Somasheila I. Murthy, Mayur R. Moreker, Virender S. Sangwan, Rohit C. Khanna, Sushma Tejwani

Erschienen in: International Ophthalmology | Ausgabe 2-3/2007

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Abstract

Purpose

To report the clinical spectrum of Vogt-Koyanagi-Harada (VKH) disease in a tertiary care center in South India.

Methods

Medical records of patients diagnosed with VKH disease who presented between January 1995 and December 2003, with a minimum follow-up of one year were reviewed.

Results

Of the 45 patients, 38 (84.44%) were female. The median age was 37 years (SD ± 14.23) and median duration of symptoms was 30 days (range 1 day to 1 year). 75.5% (34/45) presented with bilateral anterior uveitis. Posterior segment presentation included disc edema (31/45), bilateral serous retinal detachments (26/45), vitritis (17/45) and sunset glow (8/45). Extra ocular manifestations were seen in only 4/45 (tinnitus: 2, meningismus: 1, poliosis: 1). 97.7% (44/45) received oral Prednisolone (1 mg/kg body weight) for a median duration of 14 months. 69% (31/45) received additional three pulses of intravenous methylprednisolone and 22% (10/45) received a single infusion of intravenous Cyclophosphamide. One patient received intravitreal triamcinolone injection 53.33% (24/45) were treated with additional immunosupressants. At the first visit, best corrected visual acuity (BCVA) was ≥20/40 in 23 eyes (25.55%) and ≤20/400 in 37 eyes (41.11%). At one year, 61 eyes (67.77%) achieved BCVA of ≥20/40 while 12 eyes (13.33%) had BCVA ≤20/400. Complicated cataract, glaucoma and macular scar were the major complications encountered.

Conclusions

Majority of patients with ocular VKH presented with anterior uveitis and serous retinal detachments and disc edema. Extra-ocular signs are rare in our patients. Visual prognosis is good with treatment with adequate long-term corticosteroids and immunosuppressive agents.
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Metadaten
Titel
The spectrum of Vogt-Koyanagi-Harada disease in South India
verfasst von
Somasheila I. Murthy
Mayur R. Moreker
Virender S. Sangwan
Rohit C. Khanna
Sushma Tejwani
Publikationsdatum
01.06.2007
Verlag
Kluwer Academic Publishers
Erschienen in
International Ophthalmology / Ausgabe 2-3/2007
Print ISSN: 0165-5701
Elektronische ISSN: 1573-2630
DOI
https://doi.org/10.1007/s10792-007-9046-9

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