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Response Inhibition in Adults with Autism Spectrum Disorder Compared to Attention Deficit/Hyperactivity Disorder

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Abstract

Autism spectrum disorder (ASD) and attention deficit/hyperactivity disorder (ADHD) are hypothesised to involve core deficits in executive function. Previous studies have found evidence of a double dissociation between the disorders on specific executive functions (planning and response inhibition). To date most research has been conducted with children. No studies have directly compared the stable cognitive profile of adults. It was hypothesised that adults with ASD would show generally intact response inhibition whereas those with ADHD would show more global impairment. Participants were 24 adults aged 18–55 with high functioning ASD, 24 with ADHD, and 14 age and IQ matched controls. Participants completed three standardised measures of response inhibition. Participants with ASD had generally intact response inhibition but slow response latencies, possibly due to deficits in response initiation. Adults with ADHD did not show the more global impairments hypothesised. There were some significant differences between the clinical groups across measures of inhibition. In terms of performance style, adults with ASD were slow and accurate whilst those with ADHD showed an impulsive style.

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Acknowledgments

We would like to thank Dr Laura Lunt for assistance in collecting data for control participants.

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Authors and Affiliations

  1. Kings College London, Institute of Psychiatry/South London & Maudsley NHS Foundation Trust, London, UK

    Kate Johnston, Anya K. Madden & Ailsa J. Russell

  2. Adult Autism Spectrum Disorder/Attention Deficit Hyperactivity Disorder Service, Behavioural Disorders Unit, Witley 1 Ward, Bethlem Royal Hospital, Beckenham, Kent, BR3 3BX, UK

    Kate Johnston

  3. School of Psychology, University College Dublin, Newman Building, Belfield, Dublin, 4, Ireland

    Jessica Bramham

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  1. Kate Johnston
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  2. Anya K. Madden
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  4. Ailsa J. Russell
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Correspondence to Kate Johnston.

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All authors were affiliated with South London and Maudsley NHS Trust and the Institute of Psychiatry, King’s College London at the time of the study.

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Johnston, K., Madden, A.K., Bramham, J. et al. Response Inhibition in Adults with Autism Spectrum Disorder Compared to Attention Deficit/Hyperactivity Disorder. J Autism Dev Disord 41, 903–912 (2011). https://doi.org/10.1007/s10803-010-1113-9

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