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Brief Report: Early VEPs to Pattern-Reversal in Adolescents and Adults with Autism

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Abstract

Autism spectrum disorder (ASD) is characterized by atypical visual perception both in the social and nonsocial domain. In order to measure a reliable visual response, visual evoked potentials were recorded during a passive pattern-reversal stimulation in adolescents and adults with and without ASD. While the present results show the same age-related changes in both autistic and non-autistic groups, they reveal a smaller P100 amplitude in the ASD group compared to controls. These results confirm that early visual responses are affected in ASD even with a simple, non social and passive stimulation and suggest that they should be considered in order to better understand higher-level processes.

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Fig. 1
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Notes

  1. In this article, we have used N75, P100 and N135 to refer to the visual evoked potentials evoked by pattern reversal (Odom et al. 2010).

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Acknowledgments

We thank the participants and parents who volunteered in our study, as well as the individuals who helped in clinical assessments and EEG recordings.

Author Contributions

AT participated in the acquisition, analysis and interpretation of the data; KK and ABC contributed to the analysis and interpretation of the data; EHD and FBB participated in the inclusion of the participants and in the interpretation of the data; SR made a substantial contribution to the conception and design, and to the acquisition and analysis of data; MB designed the protocol and contributed to the analysis and interpretation of the data. KK, AT and MB wrote the first draft of the manuscript. All authors participated in revising it critically for important intellectual content and have given final approval of the version to be published.

Funding

The present study and the preparation of this article were supported by the Région Centre and by the Fondation Orange. This work was completed within the “Investissements d’Avenir” program of the French National Research Agency (ANR-11-IDEX-0007) and LABEX CORTEX (ANR-11-LABX-0042) of Université de Lyon (ABC).

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Authors and Affiliations

  1. Inserm, UMR U930 Imagerie et Cerveau, CHRU de Tours, Centre Universitaire de PédoPsychiatrie, Université François-Rabelais de Tours, 2 Blv Tonnellé, 37044, Tours, France

    K. Kovarski, A. Thillay, E. Houy-Durand, S. Roux, F. Bonnet-Brilhault & M. Batty

  2. Inserm, U1028, CNRS UMRS5292, Centre de Recherche en Neurosciences de Lyon, Bron, France

    A. Bidet-Caulet

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  1. K. Kovarski
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Correspondence to K. Kovarski.

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All procedures performed were in accordance with the ethics standards of the institutional and/or national research committee and with the 1964 Declaration of Helsinki and its later amendments or comparable ethical standards. The local ethics committee approved the protocol.

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Informed written consent was obtained from parents and adult subjects, and assent from the adolescents.

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K. Kovarski and A. Thillay are Joint First Authors.

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Kovarski, K., Thillay, A., Houy-Durand, E. et al. Brief Report: Early VEPs to Pattern-Reversal in Adolescents and Adults with Autism. J Autism Dev Disord 46, 3377–3386 (2016). https://doi.org/10.1007/s10803-016-2880-8

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