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Journal of Assisted Reproduction and Genetics

Erschienen in:

01.07.2007

HLA-G and its role in implantation (review)

verfasst von: Roumen G. Roussev, Carolyn B. Coulam

Erschienen in: Journal of Assisted Reproduction and Genetics | Ausgabe 7/2007

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Abstract

Background

Human leukocyte antigen G (HLA-G) is thought to play a key role in implantation by modulating cytokine secretion to control trophopblastic cell invasion and to maintain a local immunotolerance.

Method of study

The literature is reviewed to provide a description of the genetic background, properties of the protein, and the function of HLA-G. Data are presented on potential clinical applications of HLA-G including the use of evaluation of HLA-G gene polymorphisms in the diagnosis of patients experiencing recurrent pregnancy loss and evaluation and testing of soluble HLA-G (sHLA-G) in embryo culture media for the selection of embryos for transfer after in vitro fertilization (IVF).

Results

The literature supports a central role of HLA-G for successful implantation. Of couples experiencing recurrent pregnancy loss, 32% demonstrated the -1725G HLA-G polymorphism. Our data showed that when embryos were selected for transfer after IVF based on culture media concentrations of sHLA-G ≥ 2 U/ml and good morphologic grade, a 65% pregnancy rate compared with a 0% pregnancy rate in those with <2 U/ml sHLA-G.

Conclusions

HLA-G is important for successful implantation in human beings. The HLA-G -725 promoter polymorphism is a risk factor for recurrent miscarriage. Measurement of sHLA-G in embryo culture media can help select embryos for transfer after IVF allowing fewer embryos to be transferred in an attempt to lower multiple gestation rates.

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Titel: HLA-G and its role in implantation (review)
verfasst von: Roumen G. Roussev
Carolyn B. Coulam
Publikationsdatum: 01.07.2007
Verlag: Springer US
Erschienen in: Journal of Assisted Reproduction and Genetics / Ausgabe 7/2007
Print ISSN: 1058-0468
Elektronische ISSN: 1573-7330
DOI: https://doi.org/10.1007/s10815-007-9148-3

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HLA-G and its role in implantation (review)

Abstract

Background

Method of study

Results

Conclusions

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Springer Medizin

Abstract

Background

Method of study

Results

Conclusions

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