Skip to main content
Erschienen in: Journal of Assisted Reproduction and Genetics 7/2008

01.07.2008 | Assisted Reproduction

Ovarian reserve evaluation: state of the art

verfasst von: Bruno Ramalho de Carvalho, Ana Carolina Japur de Sá Rosa e Silva, Júlio César Rosa e Silva, Rosana Maria dos Reis, Rui Alberto Ferriani, Marcos Felipe Silva de Sá

Erschienen in: Journal of Assisted Reproduction and Genetics | Ausgabe 7/2008

Einloggen, um Zugang zu erhalten

Abstract

Purpose

Revise role of hormonal basal and dynamic tests, as well as ultrasonographic measures as ovarian reserve markers, in order to provide better counseling to subfertile couples.

Methods

Review of publications on the topic, with an emphasis on recent well designed articles.

Results

Currently available ovarian reserve tests do not provide sufficient evidence to be solely considered ideal, even for premature ovarian senescence patients who do not present subfertility complaints. However, these markers occupy important place in initial approach to treatment of subfertile couples, predicting unsatisfactory results that could be improved by differentiated induction schemes and reducing excessive psychological and financial burdens, and adverse effects.

Conclusions

In order to remedy the limitations due to the scarcity of strong evidence about this topic, future studies should try to clarify predictive value of markers in groups of specific diseases-related subfertility and pay special attention to propaedeutic multivariate models including anti-Müllerian hormone and antral follicle count.
Literatur
1.
Zurück zum Zitat Block E. Quantitative morphological investigations of the follicular system in women; variations at different ages. Acta Anat (Basel) 1952;14:108–23. doi:10.1159/000140595.CrossRef Block E. Quantitative morphological investigations of the follicular system in women; variations at different ages. Acta Anat (Basel) 1952;14:108–23. doi:10.​1159/​000140595.CrossRef
2.
Zurück zum Zitat Leridon H. 30 years of contraception in France. Contracept Fertil Sex 1998;26:435–8.PubMed Leridon H. 30 years of contraception in France. Contracept Fertil Sex 1998;26:435–8.PubMed
3.
Zurück zum Zitat Elgindy EA, El-Haieg DO, El-Sebaey A. Anti-Müllerian hormone: correlation of early follicular, ovulatory and midluteal levels with ovarian response and cycle outcome in intracytoplasmic sperm injection patients. Fertil Steril 2007;89:1670–6.PubMedCrossRef Elgindy EA, El-Haieg DO, El-Sebaey A. Anti-Müllerian hormone: correlation of early follicular, ovulatory and midluteal levels with ovarian response and cycle outcome in intracytoplasmic sperm injection patients. Fertil Steril 2007;89:1670–6.PubMedCrossRef
6.
Zurück zum Zitat Fanchin R, Taieb J, Lozano DHM, Ducot B, Frydman R, Bouyer J. High reproducibility of serum anti-Müllerian hormone measurements suggests a multi-staged follicular secretion and strengthens its role in the assessment of ovarian follicular status. Hum Reprod 2005;20:923–7. doi:10.1093/humrep/deh688.PubMedCrossRef Fanchin R, Taieb J, Lozano DHM, Ducot B, Frydman R, Bouyer J. High reproducibility of serum anti-Müllerian hormone measurements suggests a multi-staged follicular secretion and strengthens its role in the assessment of ovarian follicular status. Hum Reprod 2005;20:923–7. doi:10.​1093/​humrep/​deh688.PubMedCrossRef
7.
8.
Zurück zum Zitat Evers JL, Slaats P, Land JA, Dumoulin JC, Dunselman GA. Elevated levels of basal estradiol-17beta predict poor response in patients with normal basal levels of follicle-stimulating hormone undergoing in vitro fertilization. Fertil Steril 1998;69:1010–4. doi:10.1016/S0015-0282(98)00080-6.PubMedCrossRef Evers JL, Slaats P, Land JA, Dumoulin JC, Dunselman GA. Elevated levels of basal estradiol-17beta predict poor response in patients with normal basal levels of follicle-stimulating hormone undergoing in vitro fertilization. Fertil Steril 1998;69:1010–4. doi:10.​1016/​S0015-0282(98)00080-6.PubMedCrossRef
10.
Zurück zum Zitat Scott RT, Toner JP, Muasher SJ, Oehninger S, Robinson S, Rosenwaks Z. Follicle-stimulating hormone levels on cycle day 3 are predictive of in vitro fertilization outcome. Fertil Steril 1989;51:651–4.PubMed Scott RT, Toner JP, Muasher SJ, Oehninger S, Robinson S, Rosenwaks Z. Follicle-stimulating hormone levels on cycle day 3 are predictive of in vitro fertilization outcome. Fertil Steril 1989;51:651–4.PubMed
11.
Zurück zum Zitat Licciardi FL, Liu HC, Rosenwaks Z. Day 3 estradiol serum concentrations as prognosticators of ovarian stimulation response and pregnancy outcome in patients undergoing in vitro fertilization. Fertil Steril 1995;64:991–4.PubMed Licciardi FL, Liu HC, Rosenwaks Z. Day 3 estradiol serum concentrations as prognosticators of ovarian stimulation response and pregnancy outcome in patients undergoing in vitro fertilization. Fertil Steril 1995;64:991–4.PubMed
12.
Zurück zum Zitat Smotrich DB, Widra EA, Gindoff PR, Levy MJ, Hall JL, Stillman RJ. Prognostic value of day 3 estradiol on in vitro fertilization outcome. Fertil Steril 1995;64:1136–40.PubMed Smotrich DB, Widra EA, Gindoff PR, Levy MJ, Hall JL, Stillman RJ. Prognostic value of day 3 estradiol on in vitro fertilization outcome. Fertil Steril 1995;64:1136–40.PubMed
14.
Zurück zum Zitat Lee SJ, Lenton EA, Sexton L, Cooke ID. The effect of age on the cyclical patterns of plasma LH, FSH, oestradiol and progesterone in women with regular menstrual cycles. Hum Reprod 1988;3:851–5.PubMed Lee SJ, Lenton EA, Sexton L, Cooke ID. The effect of age on the cyclical patterns of plasma LH, FSH, oestradiol and progesterone in women with regular menstrual cycles. Hum Reprod 1988;3:851–5.PubMed
15.
Zurück zum Zitat Watt AH, Legedza ATR, Ginsburg ES, Barbieri RL, Clarke RN, Hornstein MD. The prognostic value of age and follicle-stimulating hormone levels in women over forty years of age undergoing in vitro fertilization. J Assist Reprod Genet 2000;17:264–8. doi:10.1023/A:1009458332567.PubMedCrossRef Watt AH, Legedza ATR, Ginsburg ES, Barbieri RL, Clarke RN, Hornstein MD. The prognostic value of age and follicle-stimulating hormone levels in women over forty years of age undergoing in vitro fertilization. J Assist Reprod Genet 2000;17:264–8. doi:10.​1023/​A:​1009458332567.PubMedCrossRef
16.
Zurück zum Zitat Franco RC, Ferriani RA, Moura MD, Reis RM, Ferreira RA, de Sala MM. Evaluation of ovarian reserve: comparison between basal FSH level and clomiphene test. Rev Bras Ginecol Obstet 2002;24:323–7. Franco RC, Ferriani RA, Moura MD, Reis RM, Ferreira RA, de Sala MM. Evaluation of ovarian reserve: comparison between basal FSH level and clomiphene test. Rev Bras Ginecol Obstet 2002;24:323–7.
17.
18.
Zurück zum Zitat Klinkert ER, Broekmans FJ, Looman CW, Habbema JD, te Velde ER. The antral follicle count is a better marker then basal follicle-stimulating hormone for the selection of older patients with acceptable pregnancy prospects after in vitro fertilization. Fertil Steril 2005;83:811–4. doi:10.1016/j.fertnstert.2004.11.005.PubMedCrossRef Klinkert ER, Broekmans FJ, Looman CW, Habbema JD, te Velde ER. The antral follicle count is a better marker then basal follicle-stimulating hormone for the selection of older patients with acceptable pregnancy prospects after in vitro fertilization. Fertil Steril 2005;83:811–4. doi:10.​1016/​j.​fertnstert.​2004.​11.​005.PubMedCrossRef
19.
21.
Zurück zum Zitat van der Steeg JW, Steures P, Eijkemans MJC, Habbema JDF, Hompes PGA, Broekmans FJ, et al. Predictive value and clinical impact of basal follicle-stimulating hormone in subfertile, ovulatory women. J Clin Endocrinol Metab 2007;92:2163–8. doi:10.1210/jc.2006-2399.PubMedCrossRef van der Steeg JW, Steures P, Eijkemans MJC, Habbema JDF, Hompes PGA, Broekmans FJ, et al. Predictive value and clinical impact of basal follicle-stimulating hormone in subfertile, ovulatory women. J Clin Endocrinol Metab 2007;92:2163–8. doi:10.​1210/​jc.​2006-2399.PubMedCrossRef
22.
Zurück zum Zitat Luna M, Grunfeld L, Mukherjee T, Sandler B, Copperman AB. Moderately elevated levels of basal follicle-stimulating hormone in young patients predict low ovarian response, but should not be used to disqualify patients from attempting in vitro fertilization. Fertil Steril 2007;87:782–7. doi:10.1016/j.fertnstert.2006.08.094.PubMedCrossRef Luna M, Grunfeld L, Mukherjee T, Sandler B, Copperman AB. Moderately elevated levels of basal follicle-stimulating hormone in young patients predict low ovarian response, but should not be used to disqualify patients from attempting in vitro fertilization. Fertil Steril 2007;87:782–7. doi:10.​1016/​j.​fertnstert.​2006.​08.​094.PubMedCrossRef
23.
Zurück zum Zitat Silberstein T, MacLaughlin DT, Shai I, Trimarchi JR, Lambert-Messerlian G, Seifer DB, et al. Müllerian inhibiting substance levels at the time of HCG administration in IVF cycles predict both ovarian reserve and embryo quality. Hum Reprod 2006;21:159–63. doi:10.1093/humrep/dei270.PubMedCrossRef Silberstein T, MacLaughlin DT, Shai I, Trimarchi JR, Lambert-Messerlian G, Seifer DB, et al. Müllerian inhibiting substance levels at the time of HCG administration in IVF cycles predict both ovarian reserve and embryo quality. Hum Reprod 2006;21:159–63. doi:10.​1093/​humrep/​dei270.PubMedCrossRef
24.
Zurück zum Zitat Fanchin R, Schonäuer LM, Righini C, Guibourdenche J, Frydman R, Taieb J. Serum anti-Müllerian hormone is more strongly related to ovarian follicular status than serum inhibin B, estradiol, FSH and LH on day 3. Hum Reprod 2003;18:323–7. doi:10.1093/humrep/deg042.PubMedCrossRef Fanchin R, Schonäuer LM, Righini C, Guibourdenche J, Frydman R, Taieb J. Serum anti-Müllerian hormone is more strongly related to ovarian follicular status than serum inhibin B, estradiol, FSH and LH on day 3. Hum Reprod 2003;18:323–7. doi:10.​1093/​humrep/​deg042.PubMedCrossRef
26.
27.
Zurück zum Zitat Klein NA, Illingworth PJ, Groome NP, McNeilly AS, Battaglia DE, Soules MR. Decreased inhibin B secretion is associated with the monotropic FSH rise in older, ovulatory women: a study of serum and follicular fluid levels of dimeric inhibin A and B in spontaneous menstrual cycles. J Clin Endocrinol Metab 1996;81:2742–5. doi:10.1210/jc.81.7.2742.PubMedCrossRef Klein NA, Illingworth PJ, Groome NP, McNeilly AS, Battaglia DE, Soules MR. Decreased inhibin B secretion is associated with the monotropic FSH rise in older, ovulatory women: a study of serum and follicular fluid levels of dimeric inhibin A and B in spontaneous menstrual cycles. J Clin Endocrinol Metab 1996;81:2742–5. doi:10.​1210/​jc.​81.​7.​2742.PubMedCrossRef
29.
Zurück zum Zitat Welt CK, Schneyer AL. Differential regulation of inhibin B and inhibin a by follicle-stimulating hormone and local growth factors in human granulosa cells from small antral follicles. Clin Endocrinol Metab 2001;86:330–6. doi:10.1210/jc.86.1.330.CrossRef Welt CK, Schneyer AL. Differential regulation of inhibin B and inhibin a by follicle-stimulating hormone and local growth factors in human granulosa cells from small antral follicles. Clin Endocrinol Metab 2001;86:330–6. doi:10.​1210/​jc.​86.​1.​330.CrossRef
30.
Zurück zum Zitat Groome NP, Illingworth PJ, O’Brien M, Pai R, Rodger FE, Mather JP, et al. Measurement of dimeric inhibin B throughout the human menstrual cycle. Clin Endocrinol Metab 1996;81:1401–5. doi:10.1210/jc.81.4.1401.CrossRef Groome NP, Illingworth PJ, O’Brien M, Pai R, Rodger FE, Mather JP, et al. Measurement of dimeric inhibin B throughout the human menstrual cycle. Clin Endocrinol Metab 1996;81:1401–5. doi:10.​1210/​jc.​81.​4.​1401.CrossRef
34.
36.
37.
Zurück zum Zitat Franchimont P, Hazeé-Hagelstein MT, Charlet-Renard C, Jaspar JM, Hazout A, Salat-Baroux J, et al. Correlation between follicular fluid content and the results of in vitro fertilization and embryo transfer. II. Inhibin and aromatase inhibitor activity. J Clin Endocrinol Metab 1990;71:748–54.PubMedCrossRef Franchimont P, Hazeé-Hagelstein MT, Charlet-Renard C, Jaspar JM, Hazout A, Salat-Baroux J, et al. Correlation between follicular fluid content and the results of in vitro fertilization and embryo transfer. II. Inhibin and aromatase inhibitor activity. J Clin Endocrinol Metab 1990;71:748–54.PubMedCrossRef
38.
Zurück zum Zitat Fowler PA, Fahy U, Culler MD, Knight PG, Wardle PG, McLaughlin EA, et al. Gonadotrophin surge-attenuating factor bioactivity is present in follicular fluid from naturally cycling women. Hum Reprod 1995;10:68–74.PubMedCrossRef Fowler PA, Fahy U, Culler MD, Knight PG, Wardle PG, McLaughlin EA, et al. Gonadotrophin surge-attenuating factor bioactivity is present in follicular fluid from naturally cycling women. Hum Reprod 1995;10:68–74.PubMedCrossRef
39.
Zurück zum Zitat Josso N. Anti-Müllerian hormone and Sertoli cell function. Horm Res 1992;38(Suppl 2):72–6.PubMed Josso N. Anti-Müllerian hormone and Sertoli cell function. Horm Res 1992;38(Suppl 2):72–6.PubMed
40.
Zurück zum Zitat Rajpert-De Meyts E, Jorgensen N, Graem N, Müller J, Cate RL, Skakkebaek NE. Expression of anti-Müllerian hormone during normal and pathological gonadal development: association with differentiation of Sertoli and granulosa cells. J Clin Endocrinol Metab 1999;84:3836–44. doi:10.1210/jc.84.10.3836.PubMedCrossRef Rajpert-De Meyts E, Jorgensen N, Graem N, Müller J, Cate RL, Skakkebaek NE. Expression of anti-Müllerian hormone during normal and pathological gonadal development: association with differentiation of Sertoli and granulosa cells. J Clin Endocrinol Metab 1999;84:3836–44. doi:10.​1210/​jc.​84.​10.​3836.PubMedCrossRef
41.
Zurück zum Zitat Weenen C, Laven JS, Von Bergh AR, Cranfield M, Groome NP, Visser JA, et al. Anti-Müllerian hormone expression pattern in the human ovary: potential implications for initial and cyclic follicle recruitment. Mol Hum Reprod 2004;10:77–83. doi:10.1093/molehr/gah015.PubMedCrossRef Weenen C, Laven JS, Von Bergh AR, Cranfield M, Groome NP, Visser JA, et al. Anti-Müllerian hormone expression pattern in the human ovary: potential implications for initial and cyclic follicle recruitment. Mol Hum Reprod 2004;10:77–83. doi:10.​1093/​molehr/​gah015.PubMedCrossRef
43.
Zurück zum Zitat Durlinger AL, Kramer P, Karels B. de long EH, Uilenbroek JT, Grootegoed JA, Themmen AP: control of primordial follicle recruitment by anti-Müllerian hormone in the mouse ovary. Endocrinology 1999;140:5789–96. doi:10.1210/en.140.12.5789.PubMedCrossRef Durlinger AL, Kramer P, Karels B. de long EH, Uilenbroek JT, Grootegoed JA, Themmen AP: control of primordial follicle recruitment by anti-Müllerian hormone in the mouse ovary. Endocrinology 1999;140:5789–96. doi:10.​1210/​en.​140.​12.​5789.PubMedCrossRef
44.
Zurück zum Zitat Durlinger AL, Gruijters MJ, Kramer P, Karels B, Kumar TR, Matzuk MM, et al. Anti-Müllerian hormone attenuates the effects of FSH on follicle development in the mouse ovary. Endocrinology 2001;142:4891–9. doi:10.1210/en.142.11.4891.PubMedCrossRef Durlinger AL, Gruijters MJ, Kramer P, Karels B, Kumar TR, Matzuk MM, et al. Anti-Müllerian hormone attenuates the effects of FSH on follicle development in the mouse ovary. Endocrinology 2001;142:4891–9. doi:10.​1210/​en.​142.​11.​4891.PubMedCrossRef
45.
Zurück zum Zitat di Clemente N, Goxe B, R’emy JJ, Cate RL, Josso N, Vigier B, Salesse R. Inhibitory effect of AMH upon aromatase activity and LH receptors of granulosa cells of rat and porcine immature ovaries. Endocrine 1994;2:553–8. di Clemente N, Goxe B, R’emy JJ, Cate RL, Josso N, Vigier B, Salesse R. Inhibitory effect of AMH upon aromatase activity and LH receptors of granulosa cells of rat and porcine immature ovaries. Endocrine 1994;2:553–8.
46.
Zurück zum Zitat Visser JA, Durlinger AL, Peters IJ, van den Heuvel ER, Rose UM, Kramer P, et al. Increased oocyte degeneration and follicular atresia during the estrous cycle in anti-Müllerian hormone null mice. Endocrinology 2007;148:2301–8. doi:10.1210/en.2006-1265.PubMedCrossRef Visser JA, Durlinger AL, Peters IJ, van den Heuvel ER, Rose UM, Kramer P, et al. Increased oocyte degeneration and follicular atresia during the estrous cycle in anti-Müllerian hormone null mice. Endocrinology 2007;148:2301–8. doi:10.​1210/​en.​2006-1265.PubMedCrossRef
47.
Zurück zum Zitat Scheffer GJ, Broekmans FJ, Dorland M, Habbema JD, Looman CW, te Velde ER. Antral follicle counts by transvaginal ultrasonography are related to age in women with proven natural fertility. Fertil Steril 1999;72:845–51. doi:10.1016/S0015-0282(99)00396-9.PubMedCrossRef Scheffer GJ, Broekmans FJ, Dorland M, Habbema JD, Looman CW, te Velde ER. Antral follicle counts by transvaginal ultrasonography are related to age in women with proven natural fertility. Fertil Steril 1999;72:845–51. doi:10.​1016/​S0015-0282(99)00396-9.PubMedCrossRef
53.
Zurück zum Zitat Hehenkamp WJK, Looman CWN, Themmen APN, de Jong FH, te Velde ER, Broekmans JM. Anti-Müllerian hormone levels in the spontaneous menstrual cycle do not show substantial fluctuation. J Clin Endocrinol Metab 2006;91:4057–63. doi:10.1210/jc.2006-0331.PubMedCrossRef Hehenkamp WJK, Looman CWN, Themmen APN, de Jong FH, te Velde ER, Broekmans JM. Anti-Müllerian hormone levels in the spontaneous menstrual cycle do not show substantial fluctuation. J Clin Endocrinol Metab 2006;91:4057–63. doi:10.​1210/​jc.​2006-0331.PubMedCrossRef
54.
Zurück zum Zitat Tsepelidis S, Devreker F, Demeestere I, Flahaut A, Gervy C, Englert Y. Stable serum levels of anti-Müllerian hormone during the menstrual cycle: a prospective study in normo-ovulatory women. Hum Reprod 2007;22:1837–40. doi:10.1093/humrep/dem101.PubMedCrossRef Tsepelidis S, Devreker F, Demeestere I, Flahaut A, Gervy C, Englert Y. Stable serum levels of anti-Müllerian hormone during the menstrual cycle: a prospective study in normo-ovulatory women. Hum Reprod 2007;22:1837–40. doi:10.​1093/​humrep/​dem101.PubMedCrossRef
57.
Zurück zum Zitat La Marca A, Giulini S, Tirelli A, Bertucci E, Marsella T, Xella S, et al. Anti-Müllerian hormone measurement on any day of the menstrual cycle strongly predicts ovarian response in assisted reproductive technology. Hum Reprod 2007;22:766–71. doi:10.1093/humrep/del421.PubMedCrossRef La Marca A, Giulini S, Tirelli A, Bertucci E, Marsella T, Xella S, et al. Anti-Müllerian hormone measurement on any day of the menstrual cycle strongly predicts ovarian response in assisted reproductive technology. Hum Reprod 2007;22:766–71. doi:10.​1093/​humrep/​del421.PubMedCrossRef
58.
Zurück zum Zitat Gnoth C, Schuring AN, Friol K, Tigges J, Mallmann P, Godehardt E. Relevance of anti-Müllerian hormone measurement in a routine IVF program. Hum Reprod 2008;23:1359–65.PubMedCrossRef Gnoth C, Schuring AN, Friol K, Tigges J, Mallmann P, Godehardt E. Relevance of anti-Müllerian hormone measurement in a routine IVF program. Hum Reprod 2008;23:1359–65.PubMedCrossRef
61.
Zurück zum Zitat Loumaye E, Billion JM, Mine JM, Psalti I, Pensis M, Thomas K. Prediction of individual response to controlled ovarian hyperstimulation by means of a clomiphene citrate challenge test. Fertil Steril 1990;53:295–301.PubMed Loumaye E, Billion JM, Mine JM, Psalti I, Pensis M, Thomas K. Prediction of individual response to controlled ovarian hyperstimulation by means of a clomiphene citrate challenge test. Fertil Steril 1990;53:295–301.PubMed
62.
Zurück zum Zitat Kwee J, Schats R, McDonnell J, Schoemaker J, Lambalk CB. The clomiphene citrate challenge test versus the exogenous follicle-stimulating hormone ovarian reserve test as a single test for identification of low responders and hyperresponders to in vitro fertilization. Fertil Steril 2006;85:1714–22. doi:10.1016/j.fertnstert.2005.11.053.PubMedCrossRef Kwee J, Schats R, McDonnell J, Schoemaker J, Lambalk CB. The clomiphene citrate challenge test versus the exogenous follicle-stimulating hormone ovarian reserve test as a single test for identification of low responders and hyperresponders to in vitro fertilization. Fertil Steril 2006;85:1714–22. doi:10.​1016/​j.​fertnstert.​2005.​11.​053.PubMedCrossRef
63.
Zurück zum Zitat Hendriks DJ, Broekmans FJ, Bancsi LF, de Jong FH, Looman CW, te Velde ER. Repeated clomiphene citrate challenge testing in the prediction of outcome in IVF: a comparison with basal markers for ovarian reserve. Hum Reprod 2005;20:163–9. doi:10.1093/humrep/deh553.PubMedCrossRef Hendriks DJ, Broekmans FJ, Bancsi LF, de Jong FH, Looman CW, te Velde ER. Repeated clomiphene citrate challenge testing in the prediction of outcome in IVF: a comparison with basal markers for ovarian reserve. Hum Reprod 2005;20:163–9. doi:10.​1093/​humrep/​deh553.PubMedCrossRef
64.
Zurück zum Zitat Haadsma ML, Bukman A, Groen H, Roeloffzen EMA, Groenewoud ER, Heineman MJ, et al. The number of small antral follicles (2–6 mm) determines the outcome of endocrine ovarian reserve tests in a subfertile population. Hum Reprod 2007;22:1925–31. doi:10.1093/humrep/dem081.PubMedCrossRef Haadsma ML, Bukman A, Groen H, Roeloffzen EMA, Groenewoud ER, Heineman MJ, et al. The number of small antral follicles (2–6 mm) determines the outcome of endocrine ovarian reserve tests in a subfertile population. Hum Reprod 2007;22:1925–31. doi:10.​1093/​humrep/​dem081.PubMedCrossRef
65.
Zurück zum Zitat Ranieri DM, Quinn F, Makhlouf A, Khadum I, Ghutmi W, McGarrigle H, et al. Simultaneous evaluation of basal follicle-stimulating hormone and 17 beta-estradiol response to gonadotropin-releasing hormone analogue stimulation: an improved predictor of ovarian reserve. Fertil Steril 1998;70:227–33. doi:10.1016/S0015-0282(98)00159-9.PubMedCrossRef Ranieri DM, Quinn F, Makhlouf A, Khadum I, Ghutmi W, McGarrigle H, et al. Simultaneous evaluation of basal follicle-stimulating hormone and 17 beta-estradiol response to gonadotropin-releasing hormone analogue stimulation: an improved predictor of ovarian reserve. Fertil Steril 1998;70:227–33. doi:10.​1016/​S0015-0282(98)00159-9.PubMedCrossRef
66.
Zurück zum Zitat Scheffer GJ, Broekmans FJM, Looman CWN, Blankenstein M, Fauser BCJM, de Jong FH, et al. The number of antral follicles in normal women with proven fertility is the best reflection of reproductive age. Hum Reprod 2003;18:700–6. doi:10.1093/humrep/deg135.PubMedCrossRef Scheffer GJ, Broekmans FJM, Looman CWN, Blankenstein M, Fauser BCJM, de Jong FH, et al. The number of antral follicles in normal women with proven fertility is the best reflection of reproductive age. Hum Reprod 2003;18:700–6. doi:10.​1093/​humrep/​deg135.PubMedCrossRef
67.
Zurück zum Zitat Ravhon A, Lavery S, Michael S, Donaldson M, Margara R, Trew G, et al. Dynamic assays of inhibin B and oestradiol following buserelin acetate administration as predictors of ovarian response in IVF. Hum Reprod 2000;15:2297–301. doi:10.1093/humrep/15.11.2297.PubMedCrossRef Ravhon A, Lavery S, Michael S, Donaldson M, Margara R, Trew G, et al. Dynamic assays of inhibin B and oestradiol following buserelin acetate administration as predictors of ovarian response in IVF. Hum Reprod 2000;15:2297–301. doi:10.​1093/​humrep/​15.​11.​2297.PubMedCrossRef
68.
Zurück zum Zitat McIlven M, Skull JD, Ledger WL. Evaluation of the utility of multiple endocrine and ultrasound measures of ovarian reserve in the prediction of cycle cancellation in a high-risk IVF population. Hum Reprod 2007;22:778–85. doi:10.1093/humrep/del435.CrossRef McIlven M, Skull JD, Ledger WL. Evaluation of the utility of multiple endocrine and ultrasound measures of ovarian reserve in the prediction of cycle cancellation in a high-risk IVF population. Hum Reprod 2007;22:778–85. doi:10.​1093/​humrep/​del435.CrossRef
69.
Zurück zum Zitat Kwee J, Elting MW, Schats R, Bezemer PD, Lambalk CB, Schoemaker J. Comparison of endocrine tests with respect to their predictive value on the outcome of ovarian hyperstimulation in IVF treatment: results of a prospective randomized study. Hum Reprod 2003;18:1422–7. doi:10.1093/humrep/deg205.PubMedCrossRef Kwee J, Elting MW, Schats R, Bezemer PD, Lambalk CB, Schoemaker J. Comparison of endocrine tests with respect to their predictive value on the outcome of ovarian hyperstimulation in IVF treatment: results of a prospective randomized study. Hum Reprod 2003;18:1422–7. doi:10.​1093/​humrep/​deg205.PubMedCrossRef
70.
Zurück zum Zitat Bancsi LFJMM, Broekmans FJM, Eijkemans MJC, de Jong FH, Habbema JDF, te Velde ER. Predictors of poor ovarian response in in vitro fertilization: a prospective study comparing basal markers of ovarian reserve. Fertil Steril 2002;77:328–36. doi:10.1016/S0015-0282(01)02983-1.PubMedCrossRef Bancsi LFJMM, Broekmans FJM, Eijkemans MJC, de Jong FH, Habbema JDF, te Velde ER. Predictors of poor ovarian response in in vitro fertilization: a prospective study comparing basal markers of ovarian reserve. Fertil Steril 2002;77:328–36. doi:10.​1016/​S0015-0282(01)02983-1.PubMedCrossRef
71.
73.
Zurück zum Zitat Verhagen TEM, Hendriks DJ, Bancsi LFJMM, Mol BWJ, Broekmans FJM. The accuracy of multivariate models predicting ovarian reserve and pregnancy after in vitro fertilization: a meta-analysis. Hum Reprod Updat 2008;14:95–100. doi:10.1093/humupd/dmn001.CrossRef Verhagen TEM, Hendriks DJ, Bancsi LFJMM, Mol BWJ, Broekmans FJM. The accuracy of multivariate models predicting ovarian reserve and pregnancy after in vitro fertilization: a meta-analysis. Hum Reprod Updat 2008;14:95–100. doi:10.​1093/​humupd/​dmn001.CrossRef
74.
Zurück zum Zitat Coulam CB, Adamson SC, Annegers JF. Incidence of premature ovarian failure. Obstet Gynecol 1986;67:604–6.PubMed Coulam CB, Adamson SC, Annegers JF. Incidence of premature ovarian failure. Obstet Gynecol 1986;67:604–6.PubMed
77.
78.
Zurück zum Zitat Doherty E, Pakarinen P, Tiitinen A, Kiilavuori A, Huhtaniemi I, Forrest S, et al. A novel mutation in the FSH receptor inhibiting signal transduction and causing primary ovarian failure. J Clin Endocrinol Metab 2002;87:1151–5. doi:10.1210/jc.87.3.1151.PubMedCrossRef Doherty E, Pakarinen P, Tiitinen A, Kiilavuori A, Huhtaniemi I, Forrest S, et al. A novel mutation in the FSH receptor inhibiting signal transduction and causing primary ovarian failure. J Clin Endocrinol Metab 2002;87:1151–5. doi:10.​1210/​jc.​87.​3.​1151.PubMedCrossRef
79.
Zurück zum Zitat Meduri G, Touraine P, Beau I, Lahuna O, Desroches A, Vacher-Lavenu MC, et al. Delayed puberty and primary amenorrhea associated with a novel mutation of the human follicle stimulating hormone receptor: clinical, histological and molecular studies. J Clin Endocrinol Metab 2003;88:3491–8. doi:10.1210/jc.2003-030217.PubMedCrossRef Meduri G, Touraine P, Beau I, Lahuna O, Desroches A, Vacher-Lavenu MC, et al. Delayed puberty and primary amenorrhea associated with a novel mutation of the human follicle stimulating hormone receptor: clinical, histological and molecular studies. J Clin Endocrinol Metab 2003;88:3491–8. doi:10.​1210/​jc.​2003-030217.PubMedCrossRef
80.
Zurück zum Zitat Gleicher N, Weghofer A, Barad DH. A pilot study of premature ovarian senescence: I. Correlation of triple CGG repeats on the FMR1 gene to ovarian reserve parameters FSH and anti-Müllerian hormone. Fertil Steril 2008;in press. Gleicher N, Weghofer A, Barad DH. A pilot study of premature ovarian senescence: I. Correlation of triple CGG repeats on the FMR1 gene to ovarian reserve parameters FSH and anti-Müllerian hormone. Fertil Steril 2008;in press.
81.
Zurück zum Zitat Gleicher N, Weghofer A, Barad DH. A pilot study of premature ovarian senescence: II. Different genotype and phenotype for genetic and autoimmune etiologies. Fertil Steril 2008;in press. Gleicher N, Weghofer A, Barad DH. A pilot study of premature ovarian senescence: II. Different genotype and phenotype for genetic and autoimmune etiologies. Fertil Steril 2008;in press.
83.
Zurück zum Zitat Rebar RW, Connolly HV. Clinical features of young women with hypergonadotropic amenorrhea. Fertil Steril 1990;53:804–10.PubMed Rebar RW, Connolly HV. Clinical features of young women with hypergonadotropic amenorrhea. Fertil Steril 1990;53:804–10.PubMed
84.
Zurück zum Zitat Nelson LM, Kimzey LM, White BJ, Merriam GR. Gonadotropin suppression for the treatment of karyotypically normal spontaneous premature ovarian failure: a controlled trial. Fertil Steril 1992;57:50–5.PubMed Nelson LM, Kimzey LM, White BJ, Merriam GR. Gonadotropin suppression for the treatment of karyotypically normal spontaneous premature ovarian failure: a controlled trial. Fertil Steril 1992;57:50–5.PubMed
85.
Zurück zum Zitat Nelson LM, Anasti JN, Kimzey LM, Defensor RA, Lipetz KJ, White BJ, et al. Development of luteinized Graafian follicles in patients with karyotypically normal spontaneous premature ovarian failure. J Clin Endocrinol Metab 1994;79:1470–5. doi:10.1210/jc.79.5.1470.PubMedCrossRef Nelson LM, Anasti JN, Kimzey LM, Defensor RA, Lipetz KJ, White BJ, et al. Development of luteinized Graafian follicles in patients with karyotypically normal spontaneous premature ovarian failure. J Clin Endocrinol Metab 1994;79:1470–5. doi:10.​1210/​jc.​79.​5.​1470.PubMedCrossRef
86.
Zurück zum Zitat Massin N, Gougeon A, Meduri G, Thibaud E, Laborde K, Matuchansky C, et al. Significance of ovarian histology in the management of patients presenting a premature ovarian failure. Hum Reprod 2004;19:2555–60. doi:10.1093/humrep/deh461.PubMedCrossRef Massin N, Gougeon A, Meduri G, Thibaud E, Laborde K, Matuchansky C, et al. Significance of ovarian histology in the management of patients presenting a premature ovarian failure. Hum Reprod 2004;19:2555–60. doi:10.​1093/​humrep/​deh461.PubMedCrossRef
87.
Zurück zum Zitat Tsigkou A, Marzotti S, Borges L, Brozzetti A, Reis F, Candeloro P, et al. High serum inhibin concentration discriminates autoimmune oophoritis from other forms of primary ovarian insufficiency. J Clin Endocrinol Metab 2008;93(4):1263–9. doi:10.1210/jc.2007-1675.PubMedCrossRef Tsigkou A, Marzotti S, Borges L, Brozzetti A, Reis F, Candeloro P, et al. High serum inhibin concentration discriminates autoimmune oophoritis from other forms of primary ovarian insufficiency. J Clin Endocrinol Metab 2008;93(4):1263–9. doi:10.​1210/​jc.​2007-1675.PubMedCrossRef
89.
Zurück zum Zitat van Rooij IA, Broekmans FJ, Scheffer GJ, Looman CW, Habbema JD, de Jong FH, et al. Serum antimullerian hormone levels best reflect the reproductive decline with age in normal women with proven fertility: a longitudinal study. Fertil Steril 2005;83:979–87. doi:10.1016/j.fertnstert.2004.11.029.PubMedCrossRef van Rooij IA, Broekmans FJ, Scheffer GJ, Looman CW, Habbema JD, de Jong FH, et al. Serum antimullerian hormone levels best reflect the reproductive decline with age in normal women with proven fertility: a longitudinal study. Fertil Steril 2005;83:979–87. doi:10.​1016/​j.​fertnstert.​2004.​11.​029.PubMedCrossRef
Metadaten
Titel
Ovarian reserve evaluation: state of the art
verfasst von
Bruno Ramalho de Carvalho
Ana Carolina Japur de Sá Rosa e Silva
Júlio César Rosa e Silva
Rosana Maria dos Reis
Rui Alberto Ferriani
Marcos Felipe Silva de Sá
Publikationsdatum
01.07.2008
Verlag
Springer US
Erschienen in
Journal of Assisted Reproduction and Genetics / Ausgabe 7/2008
Print ISSN: 1058-0468
Elektronische ISSN: 1573-7330
DOI
https://doi.org/10.1007/s10815-008-9241-2

Weitere Artikel der Ausgabe 7/2008

Journal of Assisted Reproduction and Genetics 7/2008 Zur Ausgabe

Update Gynäkologie

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert – ganz bequem per eMail.