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Journal of Assisted Reproduction and Genetics

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01.06.2010 | GENETICS

The reproductive outcome of female patients with myotonic dystrophy type 1 (DM1) undergoing PGD is not affected by the size of the expanded CTG repeat tract

verfasst von: Willem Verpoest, Sara Seneca, Marjan De Rademaeker, Karen Sermon, Martine De Rycke, Michel De Vos, Patrick Haentjens, Paul Devroey, Ingeborg Liebaers

Erschienen in: Journal of Assisted Reproduction and Genetics | Ausgabe 6/2010

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Abstract

Purpose

This study aims to analyze the relationship between trinucleotide repeat length and reproductive outcome in a large cohort of DM1 patients undergoing ICSI and PGD.

Methods

Prospective cohort study. The effect of trinucleotide repeat length on reproductive outcome per patient was analyzed using bivariate analysis (T-test) and multivariate analysis using Kaplan-Meier and Cox regression analysis.

Results

Between 1995 and 2005, 205 cycles of ICSI and PGD were carried out for DM1 in 78 couples. The number of trinucleotide repeats does not have an influence on reproductive outcome when adjusted for age, BMI, basal FSH values, parity, infertility status and male or female affected. Cox regression analysis indicates that cumulative live birth rate is not influenced by the number of trinucleotide repeats. The only factor with a significant effect is age (p < 0.05).

Conclusion

There is no evidence of an effect of trinucleotide repeat length on reproductive outcome in patients undergoing ICSI and PGD.

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Titel: The reproductive outcome of female patients with myotonic dystrophy type 1 (DM1) undergoing PGD is not affected by the size of the expanded CTG repeat tract
verfasst von: Willem Verpoest
Sara Seneca
Marjan De Rademaeker
Karen Sermon
Martine De Rycke
Michel De Vos
Patrick Haentjens
Paul Devroey
Ingeborg Liebaers
Publikationsdatum: 01.06.2010
Verlag: Springer US
Erschienen in: Journal of Assisted Reproduction and Genetics / Ausgabe 6/2010
Print ISSN: 1058-0468
Elektronische ISSN: 1573-7330
DOI: https://doi.org/10.1007/s10815-010-9392-9

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The reproductive outcome of female patients with myotonic dystrophy type 1 (DM1) undergoing PGD is not affected by the size of the expanded CTG repeat tract

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Purpose

Methods

Results

Conclusion

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