Erschienen in:
01.04.2013 | Technological Innovations
Sperm selection using magnetic activated cell sorting (MACS) in assisted reproduction: a systematic review and meta-analysis
verfasst von:
Monica Gil, Valerie Sar-Shalom, Yolisid Melendez Sivira, Ramon Carreras, Miguel Angel Checa
Erschienen in:
Journal of Assisted Reproduction and Genetics
|
Ausgabe 4/2013
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Abstract
Purpose
To determine whether the use of Magnetic Activated Cell Sorting (MACS) as a sperm selection technique improves ART success rates in couples undergoing assisted reproduction treatment.
Methods
Systematic review and meta-analysis of prospective randomized trials. Two reviewers conducted study selection and data extraction independently.
Results
Five studies (prospective randomized trials) that comprised 499 patients were included. Sperm selection using MACS resulted in statistically significant differences in pregnancy rates when compared with density gradient centrifugation and swim-up techniques (RR = 1.50, 95 % CI 1.14–1.98). No differences were found between the groups according to the implantation (RR = 1.03, 95 % CI 0.80–1.31) and miscarriage (RR = 2.00, 95 % CI 0.19–20.90) rates.
Conclusions
MACS appears to be a safe and efficient method to select functional sperm with consistently good results. This technique may improve pregnancy rates when used to complement standard sperm selection methods in ART.