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Erschienen in: Journal of Assisted Reproduction and Genetics 8/2014

01.08.2014 | Meeting Report

Birth defects and congenital health risks in children conceived through assisted reproduction technology (ART): a meeting report

verfasst von: ESHRE Capri Workshop Group

Erschienen in: Journal of Assisted Reproduction and Genetics | Ausgabe 8/2014

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Abstract

Purpose

Assisted Reproduction Treatment (ART) is here to stay. This review addresses the parental background of birth defects, before, during and after conception and focuses both on the underlying subfertility and on the question whether ART as a treatment is an additional contributing factor.

Methods

Searches were performed in Medline and other databases. Summaries were discussed in a Delphi panel set-up by the European Society of Human Reproduction and Embryology (ESHRE).

Results

Several birth defects and adult diseases arise during the earliest stages of ovarian development and oocyte differentiation: this is the case of cleft palate disorders in offspring from female rat exposed to Dioxin during fetal life or the polycystic ovary diseases in female offspring (primates) exposed to elevated androgen concentration during fetal life. Human oocytes and embryos often fail to stop the propagation of aneuploid cells but maintain their ability to repair DNA damages including those introduced by the fertilizing sperm. There is a 29 % increased risk of birth defects in the newborns spontaneously conceived by subfertile couples and the risk is further increased (34 %) when conception is achieved by treating infertlity with ART (Danish IVF Registry). Periconceptional conditions are critical for ART babies: their birth weight is in general smaller (Norvegian Registry) but a more prolonged culture time doubled the number of large babies (Finnish Registry).

Conclusion

The long-term developmental effects of ART on child and subsequent health as an adult remains a subject worthy of futher monitoring and investigation.
Fußnoten
1
Anders Forsdahl, an ordinary county doctor in a remote area of Norway first noticed that the frequency of coronary heart disease in different communities correlated to the infant mortality rate and poverty level 40 years earlier [45, 46].
 
Literatur
1.
Zurück zum Zitat Harvey W. Exercitationes de Generatione Animalium. Londinii 1651. Harvey W. Exercitationes de Generatione Animalium. Londinii 1651.
2.
Zurück zum Zitat Wilson EB. The Cell in Development and Heredity: Macmillan, New York; 1925 Wilson EB. The Cell in Development and Heredity: Macmillan, New York; 1925
3.
Zurück zum Zitat Raven Chr. P. Oogenesis: the storage of developmental information. Pergamon Press, The Macmillan Company, New York. 1961. Raven Chr. P. Oogenesis: the storage of developmental information. Pergamon Press, The Macmillan Company, New York. 1961.
4.
Zurück zum Zitat Hammond TC, Lecture M. Are follicular maturation and oocyte maturation independent processes? J Reprod Fertil. 1977;51:1–15.CrossRef Hammond TC, Lecture M. Are follicular maturation and oocyte maturation independent processes? J Reprod Fertil. 1977;51:1–15.CrossRef
5.
Zurück zum Zitat Hutt KJ, Albertini DF. An oocentric view of folliculogenesis and embryogenesis. Reprod Biomed Online. 2007;14:758–64.PubMedCrossRef Hutt KJ, Albertini DF. An oocentric view of folliculogenesis and embryogenesis. Reprod Biomed Online. 2007;14:758–64.PubMedCrossRef
6.
Zurück zum Zitat Hutt KJ, Shi Z, Albertini DF, Petroff BK. The environmental toxicant 2,3,7,8-tetrachlorodibenzo-p-dioxin disrupts morphogenesis of the rat pre-implantation embryo. BMC Dev Biol. 2008;8:1.PubMedCentralPubMedCrossRef Hutt KJ, Shi Z, Albertini DF, Petroff BK. The environmental toxicant 2,3,7,8-tetrachlorodibenzo-p-dioxin disrupts morphogenesis of the rat pre-implantation embryo. BMC Dev Biol. 2008;8:1.PubMedCentralPubMedCrossRef
7.
Zurück zum Zitat Ménézo Y, Dale B, Cohen M. DNA damage and repair in human oocytes and embryos: a review. Zygote. 2010;18:357–65.PubMedCrossRef Ménézo Y, Dale B, Cohen M. DNA damage and repair in human oocytes and embryos: a review. Zygote. 2010;18:357–65.PubMedCrossRef
8.
Zurück zum Zitat Surén P, Roth C, Bresnahan M, Haugen M, Hornig M, Hirtz D, et al. Association between maternal use of folic acid supplements and risk of autism spectrum disorders in children. JAMA. 2013;309:570–7.PubMedCentralPubMedCrossRef Surén P, Roth C, Bresnahan M, Haugen M, Hornig M, Hirtz D, et al. Association between maternal use of folic acid supplements and risk of autism spectrum disorders in children. JAMA. 2013;309:570–7.PubMedCentralPubMedCrossRef
9.
Zurück zum Zitat Ménézo Y, Mares P, Cohen M, Brack M, Viville S, Elder K. Autism, imprinting and epigenetic disorders: a metabolic syndrome linked to anomalies in homocysteine recycling starting in early life?? J Assist Reprod Genet. 2011;28:1143–5.PubMedCentralPubMedCrossRef Ménézo Y, Mares P, Cohen M, Brack M, Viville S, Elder K. Autism, imprinting and epigenetic disorders: a metabolic syndrome linked to anomalies in homocysteine recycling starting in early life?? J Assist Reprod Genet. 2011;28:1143–5.PubMedCentralPubMedCrossRef
10.
Zurück zum Zitat Hutt KJ, Shi Z, Petroff BK, Albertini DF. The environmental toxicant 2,3,7,8-tetrachlorodibenzo-p-dioxin disturbs the establishment and maintenance of cell polarity in preimplantation rat embryos. Biol Reprod. 2010;82:914–20.PubMedCentralPubMedCrossRef Hutt KJ, Shi Z, Petroff BK, Albertini DF. The environmental toxicant 2,3,7,8-tetrachlorodibenzo-p-dioxin disturbs the establishment and maintenance of cell polarity in preimplantation rat embryos. Biol Reprod. 2010;82:914–20.PubMedCentralPubMedCrossRef
11.
12.
Zurück zum Zitat Bromfield J, Messamore W, Albertini DF. Epigenetic regulation during mammalian oogenesis. Reprod Fertil Dev. 2008;20:74–80.PubMedCrossRef Bromfield J, Messamore W, Albertini DF. Epigenetic regulation during mammalian oogenesis. Reprod Fertil Dev. 2008;20:74–80.PubMedCrossRef
13.
Zurück zum Zitat Peng H, Chang B, Lu C, Su J, Wu Y, Lv P, et al. Nlrp2, a maternal effect gene required for early embryonic development in the mouse. PLoS One. 2012;7:e30344.PubMedCentralPubMedCrossRef Peng H, Chang B, Lu C, Su J, Wu Y, Lv P, et al. Nlrp2, a maternal effect gene required for early embryonic development in the mouse. PLoS One. 2012;7:e30344.PubMedCentralPubMedCrossRef
14.
Zurück zum Zitat McGinnis LK, Limback SD, Albertini DF. Signaling modalities during oogenesis in mammals. Curr Top Dev Biol. 2013;102:227–42.PubMedCrossRef McGinnis LK, Limback SD, Albertini DF. Signaling modalities during oogenesis in mammals. Curr Top Dev Biol. 2013;102:227–42.PubMedCrossRef
15.
Zurück zum Zitat Gougeon A. Ovarian follicular growth in humans: ovarian ageing and population of growing follicles. Maturitas. 1998;30:137–42.PubMedCrossRef Gougeon A. Ovarian follicular growth in humans: ovarian ageing and population of growing follicles. Maturitas. 1998;30:137–42.PubMedCrossRef
16.
17.
Zurück zum Zitat Wang RH, Sengupta K, Li C, Kim HS, Cao L, Xiao C, et al. Impaired DNA damage response, genome instability, and tumorigenesis in SIRT1 mutant mice. Cancer Cell. 2008;14:312–23.PubMedCentralPubMedCrossRef Wang RH, Sengupta K, Li C, Kim HS, Cao L, Xiao C, et al. Impaired DNA damage response, genome instability, and tumorigenesis in SIRT1 mutant mice. Cancer Cell. 2008;14:312–23.PubMedCentralPubMedCrossRef
18.
Zurück zum Zitat Nagaoka SI, Hodges CA, Albertini DF, Hunt PA. Oocyte-specific differences in cell-cycle control create an innate susceptibility to meiotic errors. Curr Biol. 2011;21:651–7.PubMedCentralPubMedCrossRef Nagaoka SI, Hodges CA, Albertini DF, Hunt PA. Oocyte-specific differences in cell-cycle control create an innate susceptibility to meiotic errors. Curr Biol. 2011;21:651–7.PubMedCentralPubMedCrossRef
19.
Zurück zum Zitat Duesberg P, Stindl R, Hehlmann R. Explaining the high mutation rates of cancer cells to drug and multidrug resistance by chromosome reassortments that are catalyzed by aneuploidy. Proc Natl Acad Sci U S A. 2000;97:14295–300.PubMedCentralPubMedCrossRef Duesberg P, Stindl R, Hehlmann R. Explaining the high mutation rates of cancer cells to drug and multidrug resistance by chromosome reassortments that are catalyzed by aneuploidy. Proc Natl Acad Sci U S A. 2000;97:14295–300.PubMedCentralPubMedCrossRef
20.
Zurück zum Zitat Duncan FE, Hornick JE, Lampson MA, Schultz RM, Shea LD, Woodruff TK. Chromosome cohesion decreases in human eggs with advanced maternal age. Aging Cell. 2012;11:1121–4.PubMedCentralPubMedCrossRef Duncan FE, Hornick JE, Lampson MA, Schultz RM, Shea LD, Woodruff TK. Chromosome cohesion decreases in human eggs with advanced maternal age. Aging Cell. 2012;11:1121–4.PubMedCentralPubMedCrossRef
21.
Zurück zum Zitat Gowen LC, Avrutskaya AV, Latour AM, Koller BH, Leadon SA. BRCA1 required for transcription-coupled repair of oxidative DNA damage. Science. 1998;281:1009–12.PubMedCrossRef Gowen LC, Avrutskaya AV, Latour AM, Koller BH, Leadon SA. BRCA1 required for transcription-coupled repair of oxidative DNA damage. Science. 1998;281:1009–12.PubMedCrossRef
22.
Zurück zum Zitat Di Giacomo M, Barchi M, Baudat F, Edelmann W, Keeney S, Jasin M. Distinct DNA-damage-dependent and -independent responses drive the loss of oocytes in recombination-defective mouse mutants. Proc Natl Acad Sci U S A. 2005;102:737–42.PubMedCentralPubMedCrossRef Di Giacomo M, Barchi M, Baudat F, Edelmann W, Keeney S, Jasin M. Distinct DNA-damage-dependent and -independent responses drive the loss of oocytes in recombination-defective mouse mutants. Proc Natl Acad Sci U S A. 2005;102:737–42.PubMedCentralPubMedCrossRef
23.
Zurück zum Zitat Ménézo Jr Y, Russo G, Tosti E, El Mouatassim S, Benkhalifa M. Expression profile of genes coding for DNA repair in human oocytes using pangenomic microarrays, with a special focus on ROS linked decays. J Assist Reprod Genet. 2007;24:513–20.PubMedCentralPubMedCrossRef Ménézo Jr Y, Russo G, Tosti E, El Mouatassim S, Benkhalifa M. Expression profile of genes coding for DNA repair in human oocytes using pangenomic microarrays, with a special focus on ROS linked decays. J Assist Reprod Genet. 2007;24:513–20.PubMedCentralPubMedCrossRef
25.
Zurück zum Zitat Draper ES, Kurinczuk JJ, Abrams KR, Clarke M. Assessment of separate contributions to perinatal mortality of infertility history and treatment: a case–control analysis. Lancet. 1999;353:1746–9.PubMedCrossRef Draper ES, Kurinczuk JJ, Abrams KR, Clarke M. Assessment of separate contributions to perinatal mortality of infertility history and treatment: a case–control analysis. Lancet. 1999;353:1746–9.PubMedCrossRef
26.
Zurück zum Zitat Zhu JL, Basso O, Obel C, Bille C, Olsen J. Infertility, infertility treatment, and congenital malformations: Danish national birth cohort. BMJ. 2006;333:679–84.PubMedCentralPubMedCrossRef Zhu JL, Basso O, Obel C, Bille C, Olsen J. Infertility, infertility treatment, and congenital malformations: Danish national birth cohort. BMJ. 2006;333:679–84.PubMedCentralPubMedCrossRef
27.
Zurück zum Zitat Henriksen TB, Baird DD, Olsen J, Hedegaard M, Secher NJ, Wilcox AJ. Time to pregnancy and preterm delivery. Obstet Gynecol. 1997;89:594–9.PubMedCrossRef Henriksen TB, Baird DD, Olsen J, Hedegaard M, Secher NJ, Wilcox AJ. Time to pregnancy and preterm delivery. Obstet Gynecol. 1997;89:594–9.PubMedCrossRef
28.
Zurück zum Zitat Bhalla AK, Sarala G, Dhaliwal L. Pregnancy following infertility. Aust N Z J Obstet Gynaecol. 1992;32:249–51.PubMedCrossRef Bhalla AK, Sarala G, Dhaliwal L. Pregnancy following infertility. Aust N Z J Obstet Gynaecol. 1992;32:249–51.PubMedCrossRef
29.
Zurück zum Zitat Joffe M, Li Z. Association of time to pregnancy and the outcome of pregnancy. Fertil Steril. 1994;62:71–5.PubMed Joffe M, Li Z. Association of time to pregnancy and the outcome of pregnancy. Fertil Steril. 1994;62:71–5.PubMed
30.
Zurück zum Zitat Messerlian C, Maclagan L, Basso O. Infertility and the risk of adverse pregnancy outcomes: a systematic review and meta-analysis. Hum Reprod. 2013;28:125–37.PubMedCrossRef Messerlian C, Maclagan L, Basso O. Infertility and the risk of adverse pregnancy outcomes: a systematic review and meta-analysis. Hum Reprod. 2013;28:125–37.PubMedCrossRef
31.
Zurück zum Zitat Romundstad LB, Romundstad PR, Sunde A, von During V, Skjaerven R, Gunnel D, et al. Effects of technology or maternal factors on perinatal outcome of assisted reproduction: a population-based cochort study. Lancet. 2008;372:737–43.PubMedCrossRef Romundstad LB, Romundstad PR, Sunde A, von During V, Skjaerven R, Gunnel D, et al. Effects of technology or maternal factors on perinatal outcome of assisted reproduction: a population-based cochort study. Lancet. 2008;372:737–43.PubMedCrossRef
32.
33.
Zurück zum Zitat Chung K, Coutifaris C, Chalian R, Lin K, Ratcliffe SJ, Castelbaum AJ, et al. Factors influencing adverse perinatal outcomes in pregnancies achieved through use of in vitro fertilization. Fertil Steril. 2006;86:1634–41.PubMedCrossRef Chung K, Coutifaris C, Chalian R, Lin K, Ratcliffe SJ, Castelbaum AJ, et al. Factors influencing adverse perinatal outcomes in pregnancies achieved through use of in vitro fertilization. Fertil Steril. 2006;86:1634–41.PubMedCrossRef
34.
Zurück zum Zitat Anthony S, Buitendijk SE, Dorrepaal CA, Lindner K, Braat DD, den Ouden AL. Congenital malformations in 4224 children conceived after IVF. Hum Reprod. 2002;17:2089–95.PubMedCrossRef Anthony S, Buitendijk SE, Dorrepaal CA, Lindner K, Braat DD, den Ouden AL. Congenital malformations in 4224 children conceived after IVF. Hum Reprod. 2002;17:2089–95.PubMedCrossRef
35.
Zurück zum Zitat Hansen M, Kurinczuk JJ, Bower C, Webb S. The risk of major birth defects after intracytoplasmic sperm injection and in vitro fertilization. N Engl J Med. 2002;346:725–30.PubMedCrossRef Hansen M, Kurinczuk JJ, Bower C, Webb S. The risk of major birth defects after intracytoplasmic sperm injection and in vitro fertilization. N Engl J Med. 2002;346:725–30.PubMedCrossRef
36.
Zurück zum Zitat Davies MJ, Moore VM, Willson KJ, Van Essen P, Priest K, Scott H, et al. Reproductive technologies and the risk of birth defects. N Engl J Med. 2012;366:1803–13.PubMedCrossRef Davies MJ, Moore VM, Willson KJ, Van Essen P, Priest K, Scott H, et al. Reproductive technologies and the risk of birth defects. N Engl J Med. 2012;366:1803–13.PubMedCrossRef
37.
Zurück zum Zitat Hansen M, Kurinckzuk JJ, Milne E, de Klerk N, Bower C. Assisted reproductive technology and birth defects: a systematic review and meta-analysis. Hum Reprod Update. 2013;19:330–53.PubMedCrossRef Hansen M, Kurinckzuk JJ, Milne E, de Klerk N, Bower C. Assisted reproductive technology and birth defects: a systematic review and meta-analysis. Hum Reprod Update. 2013;19:330–53.PubMedCrossRef
38.
Zurück zum Zitat De Graaff AA, Land JA, Kessels AG, Evers JL. Demographic age shift toward later conception results in an increased age in the subfertile population and an increased demand for medical care. Fertil Steril. 2011;95:61–3.PubMedCrossRef De Graaff AA, Land JA, Kessels AG, Evers JL. Demographic age shift toward later conception results in an increased age in the subfertile population and an increased demand for medical care. Fertil Steril. 2011;95:61–3.PubMedCrossRef
39.
Zurück zum Zitat Baird DD, Wilcox AJ, Kramer MS. Why might infertile couples have problem pregnancies? Lancet. 1999;353:1724–5.PubMedCrossRef Baird DD, Wilcox AJ, Kramer MS. Why might infertile couples have problem pregnancies? Lancet. 1999;353:1724–5.PubMedCrossRef
40.
Zurück zum Zitat Mau Kai C, Juul A, McElreavey K, Ottesen AM, Garn ID, Main KM, et al. Sons conceived by assisted reproduction techniques inherit deletions in the azoospermia factor (AZF) region of the Y chromosome and the DAZ gene copy number. Hum Reprod. 2008;23:1669–78.PubMedCrossRef Mau Kai C, Juul A, McElreavey K, Ottesen AM, Garn ID, Main KM, et al. Sons conceived by assisted reproduction techniques inherit deletions in the azoospermia factor (AZF) region of the Y chromosome and the DAZ gene copy number. Hum Reprod. 2008;23:1669–78.PubMedCrossRef
41.
Zurück zum Zitat Goldberg AD, Allis CD, Bernstein E. Epigenetics: a landscape takes shape. Cell. 2007;128:635–8.PubMedCrossRef Goldberg AD, Allis CD, Bernstein E. Epigenetics: a landscape takes shape. Cell. 2007;128:635–8.PubMedCrossRef
42.
Zurück zum Zitat Reik W, Walter J. Genomic imprinting: parental influence on the genome. Nat Rev Genet. 2001;2:21–32.PubMedCrossRef Reik W, Walter J. Genomic imprinting: parental influence on the genome. Nat Rev Genet. 2001;2:21–32.PubMedCrossRef
43.
Zurück zum Zitat ESHRE Capri Workshop Group. Nutrition and reproduction in women. Hum Reprod Update. 2006;12:193–207.CrossRef ESHRE Capri Workshop Group. Nutrition and reproduction in women. Hum Reprod Update. 2006;12:193–207.CrossRef
45.
Zurück zum Zitat Forsdahl A. Are poor living conditions in childhood and adolescence an important risk factor for arteriosclerotic heart disease. J Prevent Soc Med. 1977;31:91–5. Forsdahl A. Are poor living conditions in childhood and adolescence an important risk factor for arteriosclerotic heart disease. J Prevent Soc Med. 1977;31:91–5.
46.
Zurück zum Zitat Forsdahl A. Living conditions in childhood and subsequent development of risk factors for arteriosclerotic heart disease. J Epidemiol Commun Health. 1978;32:34–7.CrossRef Forsdahl A. Living conditions in childhood and subsequent development of risk factors for arteriosclerotic heart disease. J Epidemiol Commun Health. 1978;32:34–7.CrossRef
47.
Zurück zum Zitat Painter RC, Roseboom TJ, Bleker OP. Prenatal exposure to the dutch famine and disease in later life: an overview. Reprod Toxicol. 2005;20:345–52.PubMedCrossRef Painter RC, Roseboom TJ, Bleker OP. Prenatal exposure to the dutch famine and disease in later life: an overview. Reprod Toxicol. 2005;20:345–52.PubMedCrossRef
48.
Zurück zum Zitat Lucock M. Folic acid: nutritional biochemistry, molecular biology, and role in disease processes. Mol Genet Metab. 2000;71:121–38.PubMedCrossRef Lucock M. Folic acid: nutritional biochemistry, molecular biology, and role in disease processes. Mol Genet Metab. 2000;71:121–38.PubMedCrossRef
49.
Zurück zum Zitat Refsum H, Nurk E, Smith AD, Ueland PM, Gjesdal CG, Bjelland I, et al. The hordaland homocysteine study: a community-based study of homocysteine, its determinants, and associations with disease. J Nutr. 2006;136(6 Suppl):1731S–40S.PubMed Refsum H, Nurk E, Smith AD, Ueland PM, Gjesdal CG, Bjelland I, et al. The hordaland homocysteine study: a community-based study of homocysteine, its determinants, and associations with disease. J Nutr. 2006;136(6 Suppl):1731S–40S.PubMed
50.
Zurück zum Zitat Rush EC, Katre P, Yajnik CS. Vitamin B12: one carbon metabolism, fetal growth and programming of chronic disease. Eur J Clin Nutr. 2014;68:2–7.PubMedCrossRef Rush EC, Katre P, Yajnik CS. Vitamin B12: one carbon metabolism, fetal growth and programming of chronic disease. Eur J Clin Nutr. 2014;68:2–7.PubMedCrossRef
51.
Zurück zum Zitat Sinclair KD, Allegrucci C, Singh R, Gardner DS, Sebastian S, Bispham J, et al. DNA methylation, insulin resistance, and blood pressure in offspring determined by maternal periconceptional B vitamin and methionine status. Proc Natl Acad Sci U S A. 2007;104:19351–6.PubMedCentralPubMedCrossRef Sinclair KD, Allegrucci C, Singh R, Gardner DS, Sebastian S, Bispham J, et al. DNA methylation, insulin resistance, and blood pressure in offspring determined by maternal periconceptional B vitamin and methionine status. Proc Natl Acad Sci U S A. 2007;104:19351–6.PubMedCentralPubMedCrossRef
52.
Zurück zum Zitat Steegers-Theunissen RPM, Twigt J, Pestinger V, Sinclair KD. The periconceptional period, reproduction and long-term health of offspring: the importance of one-carbon metabolism. Hum Reprod Update. 2013;19:640–55.PubMedCrossRef Steegers-Theunissen RPM, Twigt J, Pestinger V, Sinclair KD. The periconceptional period, reproduction and long-term health of offspring: the importance of one-carbon metabolism. Hum Reprod Update. 2013;19:640–55.PubMedCrossRef
53.
Zurück zum Zitat Ng SF, Lin RC, Laybutt DR, Barres R, Owens JA, Morris MJ. Chronic high-fat diet in fathers programs β-cell dysfunction in female rat offspring. Nature. 2010;467:963–6.PubMedCrossRef Ng SF, Lin RC, Laybutt DR, Barres R, Owens JA, Morris MJ. Chronic high-fat diet in fathers programs β-cell dysfunction in female rat offspring. Nature. 2010;467:963–6.PubMedCrossRef
54.
Zurück zum Zitat Soubry A, Schildkraut JM, Murtha A, Wang F, Huang Z, Bernal A, et al. Paternal obesity is associated with IGF2 hypomethylation in newborns: results from a Newborn Epigenetics Study (NEST) cohort. BMC Med. 2013;11:29.PubMedCentralPubMedCrossRef Soubry A, Schildkraut JM, Murtha A, Wang F, Huang Z, Bernal A, et al. Paternal obesity is associated with IGF2 hypomethylation in newborns: results from a Newborn Epigenetics Study (NEST) cohort. BMC Med. 2013;11:29.PubMedCentralPubMedCrossRef
56.
Zurück zum Zitat Sharpe RM, Skakkebaek NE. Testicular dysgenesis syndrome: mechanistic insights and potential new downstream effects. Fertil Steril. 2008;89 Suppl 1:e33–8.PubMedCrossRef Sharpe RM, Skakkebaek NE. Testicular dysgenesis syndrome: mechanistic insights and potential new downstream effects. Fertil Steril. 2008;89 Suppl 1:e33–8.PubMedCrossRef
57.
Zurück zum Zitat Welsh M, Saunders PTK, Fisken M, Scott HM, Hutchison GR, Smith LB, et al. Identification in rats of a programming window for reproductive tract masculinization, disruption of which leads to hypospadias and cryptorchidism. J Clin Invest. 2008;118:1479–90.PubMedCentralPubMedCrossRef Welsh M, Saunders PTK, Fisken M, Scott HM, Hutchison GR, Smith LB, et al. Identification in rats of a programming window for reproductive tract masculinization, disruption of which leads to hypospadias and cryptorchidism. J Clin Invest. 2008;118:1479–90.PubMedCentralPubMedCrossRef
58.
Zurück zum Zitat Dean A, Sharpe RM. Anogenital distance or digit length ratio as measures of fetal androgen exposure: relationship to male reproductive development and its disorders. J Clin Endocrinol Metab. 2013;98:2230–8.PubMedCrossRef Dean A, Sharpe RM. Anogenital distance or digit length ratio as measures of fetal androgen exposure: relationship to male reproductive development and its disorders. J Clin Endocrinol Metab. 2013;98:2230–8.PubMedCrossRef
59.
Zurück zum Zitat Drake AJ, Van den Driesche S, Scott HM, Hutchison G, Seckl JR, Sharpe RM. Glucocorticoids amplify dibutyl phthalate-induced disruption of fetal testosterone production and male reproductive development. Endocrinology. 2009;150:5055–64.PubMedCrossRef Drake AJ, Van den Driesche S, Scott HM, Hutchison G, Seckl JR, Sharpe RM. Glucocorticoids amplify dibutyl phthalate-induced disruption of fetal testosterone production and male reproductive development. Endocrinology. 2009;150:5055–64.PubMedCrossRef
60.
Zurück zum Zitat Hart R, Norman RJ. The longer-term health outcomes for children born as a result of IVF treatment: part I – general health outcomes. Hum Reprod Update. 2013;19:232–43.PubMedCrossRef Hart R, Norman RJ. The longer-term health outcomes for children born as a result of IVF treatment: part I – general health outcomes. Hum Reprod Update. 2013;19:232–43.PubMedCrossRef
61.
Zurück zum Zitat Hart R, Norman RJ. The longer-term health outcomes for children born as a result of IVF treatment. Part II – mental health and development outcomes. Hum Reprod Update. 2013;19:244–50.PubMedCrossRef Hart R, Norman RJ. The longer-term health outcomes for children born as a result of IVF treatment. Part II – mental health and development outcomes. Hum Reprod Update. 2013;19:244–50.PubMedCrossRef
62.
Zurück zum Zitat van Montfoort AP, Hanssen LL, de Sutter P, Viville S, Geraedts JP, de Boer P. Assisted reproduction treatment and epigenetic inheritance. Hum Reprod Update. 2012;18:171–97.PubMedCentralPubMedCrossRef van Montfoort AP, Hanssen LL, de Sutter P, Viville S, Geraedts JP, de Boer P. Assisted reproduction treatment and epigenetic inheritance. Hum Reprod Update. 2012;18:171–97.PubMedCentralPubMedCrossRef
63.
Zurück zum Zitat Haouzi D, Assou S, Dechanet C, Anahory T, Dechaud H, De Vos J, et al. Controlled ovarian hyperstimulation for in vitro fertilization alters endometrial receptivity in humans: protocol effects. Biol Reprod. 2010;82:679–86.PubMedCrossRef Haouzi D, Assou S, Dechanet C, Anahory T, Dechaud H, De Vos J, et al. Controlled ovarian hyperstimulation for in vitro fertilization alters endometrial receptivity in humans: protocol effects. Biol Reprod. 2010;82:679–86.PubMedCrossRef
64.
Zurück zum Zitat Vermeiden JP, Bernardus RE. Are imprinting disorders more prevalent after human in vitro fertilization or intracytoplasmic sperm injection? Fertil Steril. 2013;99:642–51.PubMedCrossRef Vermeiden JP, Bernardus RE. Are imprinting disorders more prevalent after human in vitro fertilization or intracytoplasmic sperm injection? Fertil Steril. 2013;99:642–51.PubMedCrossRef
65.
Zurück zum Zitat Katari S, Turan N, Bibikova M, Erinle O, Chalian R, Foster M, et al. DNA methylation and gene expression differences in children conceived in vitro or in vivo. Hum Mol Genet. 2009;18:3769–78.PubMedCentralPubMedCrossRef Katari S, Turan N, Bibikova M, Erinle O, Chalian R, Foster M, et al. DNA methylation and gene expression differences in children conceived in vitro or in vivo. Hum Mol Genet. 2009;18:3769–78.PubMedCentralPubMedCrossRef
66.
Zurück zum Zitat Eskild A, Monkerud L, Tanbo T. Birthweight and placental weight; do changes in culture media used for IVF matter? Comparisons with spontaneous pregnancies in the corresponding time periods. Hum Reprod. 2013;28:3207–14.PubMedCrossRef Eskild A, Monkerud L, Tanbo T. Birthweight and placental weight; do changes in culture media used for IVF matter? Comparisons with spontaneous pregnancies in the corresponding time periods. Hum Reprod. 2013;28:3207–14.PubMedCrossRef
67.
Zurück zum Zitat Dumoulin JC, Land JA, Van Montfoort AP, Nelissen EC, Coonen E, Derhaag JG, et al. Effect of in vitro culture of human embryos on birthweight of newborns. Hum Reprod. 2010;25:605–12.PubMedCrossRef Dumoulin JC, Land JA, Van Montfoort AP, Nelissen EC, Coonen E, Derhaag JG, et al. Effect of in vitro culture of human embryos on birthweight of newborns. Hum Reprod. 2010;25:605–12.PubMedCrossRef
68.
Zurück zum Zitat Mäkinen S, Söderström-Anttila V, Vainio J, Suikkari AM, Tuuri T. Does long in vitro culture promote large for gestational age babies? Hum Reprod. 2013;28:828–34.PubMedCrossRef Mäkinen S, Söderström-Anttila V, Vainio J, Suikkari AM, Tuuri T. Does long in vitro culture promote large for gestational age babies? Hum Reprod. 2013;28:828–34.PubMedCrossRef
69.
Zurück zum Zitat Chen Z, Robbins KM, Wells KD, Rivera RM. Large offspring syndrome: a bovine model for the human loss-of-imprinting overgrowth syndrome beckwith-wiedemann. Epigenetics. 2013;8:591–601.PubMedCentralPubMedCrossRef Chen Z, Robbins KM, Wells KD, Rivera RM. Large offspring syndrome: a bovine model for the human loss-of-imprinting overgrowth syndrome beckwith-wiedemann. Epigenetics. 2013;8:591–601.PubMedCentralPubMedCrossRef
70.
Zurück zum Zitat Lin S, Li M, Lian Y, Chen L, Liu P. No effect of embryo culture media on birthweight and length of newborns. Hum Reprod. 2013;28:1762–7.PubMedCrossRef Lin S, Li M, Lian Y, Chen L, Liu P. No effect of embryo culture media on birthweight and length of newborns. Hum Reprod. 2013;28:1762–7.PubMedCrossRef
71.
Zurück zum Zitat Carrasco B, Boada M, Rodríguez I, Coroleu B, Barri PN, Veiga A. Does culture medium influence offspring birth weight? Fertil Steril. 2013;100:1283–8.PubMedCrossRef Carrasco B, Boada M, Rodríguez I, Coroleu B, Barri PN, Veiga A. Does culture medium influence offspring birth weight? Fertil Steril. 2013;100:1283–8.PubMedCrossRef
72.
Zurück zum Zitat Scott Jr RT, Upham KM, Forman EJ, Hong KH, Scott KL, Taylor D, et al. Blastocyst biopsy with comprehensive chromosome screening and fresh embryo transfer significantly increases in vitro fertilization implantation and delivery rates: a randomized controlled trial. Fertil Steril. 2013;100:697–703.PubMedCrossRef Scott Jr RT, Upham KM, Forman EJ, Hong KH, Scott KL, Taylor D, et al. Blastocyst biopsy with comprehensive chromosome screening and fresh embryo transfer significantly increases in vitro fertilization implantation and delivery rates: a randomized controlled trial. Fertil Steril. 2013;100:697–703.PubMedCrossRef
73.
Zurück zum Zitat Rubio C, Bellver J, Rodrigo L, Bosch E, Mercader A, Vidal C, et al. Preimplantation genetic screening using fluorescence in situ hybridization in patients with repetitive implantation failure and advanced maternal age: two randomized trials. Fertil Steril. 2013;99:1400–7.PubMedCrossRef Rubio C, Bellver J, Rodrigo L, Bosch E, Mercader A, Vidal C, et al. Preimplantation genetic screening using fluorescence in situ hybridization in patients with repetitive implantation failure and advanced maternal age: two randomized trials. Fertil Steril. 2013;99:1400–7.PubMedCrossRef
74.
Zurück zum Zitat Mastenbroek S, Twisk M, van Echten-Arends J, Sikkema-Raddatz B, Korevaar JC, Verhoeve HR, et al. In vitro fertilization with preimplantation genetic screening. N Engl J Med. 2007;357:9–17.PubMedCrossRef Mastenbroek S, Twisk M, van Echten-Arends J, Sikkema-Raddatz B, Korevaar JC, Verhoeve HR, et al. In vitro fertilization with preimplantation genetic screening. N Engl J Med. 2007;357:9–17.PubMedCrossRef
75.
Zurück zum Zitat Alfarawati S, Fragouli E, Colls P, Stevens J, Gutiérrez-Mateo C, Schoolcraft WB, et al. The relationship between blastocyst morphology, chromosomal abnormality, and embryo gender. Fertil Steril. 2011;95:520–4.PubMedCrossRef Alfarawati S, Fragouli E, Colls P, Stevens J, Gutiérrez-Mateo C, Schoolcraft WB, et al. The relationship between blastocyst morphology, chromosomal abnormality, and embryo gender. Fertil Steril. 2011;95:520–4.PubMedCrossRef
76.
Zurück zum Zitat Henningsen AK, Romundstad LB, Gissler M, Nygren KG, Lidegaard O, Skjaerven R, et al. Infant and maternal health monitoring using a combined Nordic database on ART and safety. Acta Obstet Gyn Scand. 2011;90:683–91.CrossRef Henningsen AK, Romundstad LB, Gissler M, Nygren KG, Lidegaard O, Skjaerven R, et al. Infant and maternal health monitoring using a combined Nordic database on ART and safety. Acta Obstet Gyn Scand. 2011;90:683–91.CrossRef
77.
Zurück zum Zitat Myklestad K, Vatten LJ, Magnussen EB, Salvesen KA, Smith GD, Romundstad PR. Offspring birth weight and cardiovascular risk in parents: a population-based HUNT 2 study. Am J Epidemiol. 2012;175:546–55.PubMedCrossRef Myklestad K, Vatten LJ, Magnussen EB, Salvesen KA, Smith GD, Romundstad PR. Offspring birth weight and cardiovascular risk in parents: a population-based HUNT 2 study. Am J Epidemiol. 2012;175:546–55.PubMedCrossRef
78.
Zurück zum Zitat Ceelen M, van Weissenbruch MM, Vermeiden JP, van Leeuwen FE, de Waal HA D-v. Cardiometabolic differences in children born after in vitro fertilization: follow-up study. J Clin Endocrinol Metab. 2008;93:1682–8.PubMedCrossRef Ceelen M, van Weissenbruch MM, Vermeiden JP, van Leeuwen FE, de Waal HA D-v. Cardiometabolic differences in children born after in vitro fertilization: follow-up study. J Clin Endocrinol Metab. 2008;93:1682–8.PubMedCrossRef
79.
Zurück zum Zitat Ceelen M, van Weissenbruch MM, Prein J, Smit JJ, Vermeiden JP, Spreeuwenberg M, et al. Delemarre-van de Waal HA. Growth during infancy and early childhood in relation to blood pressure and body fat measures at age 8–18 years of IVF children and spontaneously conceived controls born to subfertile parents. Hum Reprod. 2009;24:2788–95.PubMedCrossRef Ceelen M, van Weissenbruch MM, Prein J, Smit JJ, Vermeiden JP, Spreeuwenberg M, et al. Delemarre-van de Waal HA. Growth during infancy and early childhood in relation to blood pressure and body fat measures at age 8–18 years of IVF children and spontaneously conceived controls born to subfertile parents. Hum Reprod. 2009;24:2788–95.PubMedCrossRef
80.
Zurück zum Zitat Belva F, Roelants M, De Schepper J, Roseboom TJ, Bonduelle M, Devroey P, et al. Blood pressure in ICSI-conceived adolescents. Hum Reprod. 2012;27:3100–8.PubMedCrossRef Belva F, Roelants M, De Schepper J, Roseboom TJ, Bonduelle M, Devroey P, et al. Blood pressure in ICSI-conceived adolescents. Hum Reprod. 2012;27:3100–8.PubMedCrossRef
81.
Zurück zum Zitat Scherrer U, Rimoldi SF, Rexhaj E, Stuber T, Duplain H, Garcin S, et al. Systemic and pulmonary vascular dysfunction in children conceived by assisted reproductive technologies. Circulation. 2012;125:1890–6.PubMedCrossRef Scherrer U, Rimoldi SF, Rexhaj E, Stuber T, Duplain H, Garcin S, et al. Systemic and pulmonary vascular dysfunction in children conceived by assisted reproductive technologies. Circulation. 2012;125:1890–6.PubMedCrossRef
82.
Zurück zum Zitat Ceelen M, van Weissenbruch MM, Roos JC, Vermeiden JP, van Leeuwen FE, de Waal HA D-v. Body composition in children and adolescents born after in vitro fertilization or spontaneous conception. J Clin Endocrinol Metab. 2007;92:3417–23.PubMedCrossRef Ceelen M, van Weissenbruch MM, Roos JC, Vermeiden JP, van Leeuwen FE, de Waal HA D-v. Body composition in children and adolescents born after in vitro fertilization or spontaneous conception. J Clin Endocrinol Metab. 2007;92:3417–23.PubMedCrossRef
83.
Zurück zum Zitat Romundstad LB, Romundstad PR, Sunde A, von During V, Skjaerven R, Vatten LJ. Increased risk of placenta previa in pregnancies following IVF/ICSI; a comparison of ART and non-ART pregnancies in the same mother. Hum Reprod. 2006;21:2353–8.PubMedCrossRef Romundstad LB, Romundstad PR, Sunde A, von During V, Skjaerven R, Vatten LJ. Increased risk of placenta previa in pregnancies following IVF/ICSI; a comparison of ART and non-ART pregnancies in the same mother. Hum Reprod. 2006;21:2353–8.PubMedCrossRef
84.
Zurück zum Zitat Kallen B, Finnstrom O, Nygren KG, Olausson PO. In vitro fertilization in Sweden: child morbidity including cancer risk. Fertil Steril. 2005;84:605–10.PubMedCrossRef Kallen B, Finnstrom O, Nygren KG, Olausson PO. In vitro fertilization in Sweden: child morbidity including cancer risk. Fertil Steril. 2005;84:605–10.PubMedCrossRef
85.
Zurück zum Zitat Kallen B, Finnstrom O, Lindam A, Nilsson E, Nygren KG, Olausson PO. Cancer risk in children and young adults conceived by in vitro fertilization. Pediatrics. 2010;126:270–6.PubMedCrossRef Kallen B, Finnstrom O, Lindam A, Nilsson E, Nygren KG, Olausson PO. Cancer risk in children and young adults conceived by in vitro fertilization. Pediatrics. 2010;126:270–6.PubMedCrossRef
Metadaten
Titel
Birth defects and congenital health risks in children conceived through assisted reproduction technology (ART): a meeting report
verfasst von
ESHRE Capri Workshop Group
Publikationsdatum
01.08.2014
Verlag
Springer US
Erschienen in
Journal of Assisted Reproduction and Genetics / Ausgabe 8/2014
Print ISSN: 1058-0468
Elektronische ISSN: 1573-7330
DOI
https://doi.org/10.1007/s10815-014-0255-7

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