Skip to main content
Erschienen in: Journal of Assisted Reproduction and Genetics 11/2014

01.11.2014 | Letter to the Editor

No malignancy detected in surplus ovarian tissue from a former Ewing sarcoma patient who experienced relapse four years after being grafted with frozen/thawed ovarian tissue

verfasst von: Claus Yding Andersen, Erik Ernst, Steen Bærentzen, Niels H. Birkebæk, Niels Clausen

Erschienen in: Journal of Assisted Reproduction and Genetics | Ausgabe 11/2014

Einloggen, um Zugang zu erhalten

Excerpt

We have recently published a case report describing the first case of grafting frozen/thawed ovarian tissue for puberty induction to a young girl who had recovered from a malignant disease [1]. She had one of her ovaries frozen at 9 years of age prior to undergoing treatment for Ewing sarcoma, which included pre— and post operative chemotherapy comprising (total accumulated dose per m2), vincristine (21 mg), ifosfamide (60 g), doxorubicin (360 mg), etoposide (2.7 mg), actinomycin (9 mg), and cyclophosphamide (10.5 g) according to the EURO EWING-99 protocol. Subsequently, she underwent gross total surgical resection. Histological examination confirmed resection into healthy tissue. Postoperatively, a total irradiation dose of 41.2 Gy to the tumor bed during 23 treatments was given. When she was 13 years and had no ovarian activity, two of ten pieces of ovarian cortex were grafted to the remaining postmenopausal ovary. The grafted tissue regained activity and stimulated her pubertal development. …
Literatur
1.
Zurück zum Zitat Ernst E, Kjærsgaard M, Birkebæk NH, Clausen N, Yding Andersen C. Stimulation of puberty in a girl with chemo—and radiation therapy induced ovarian failure by transplantation of a small part of her frozen/thawed ovarian tissue. Eur J Cancer. 2013;49:911–4.PubMedCrossRef Ernst E, Kjærsgaard M, Birkebæk NH, Clausen N, Yding Andersen C. Stimulation of puberty in a girl with chemo—and radiation therapy induced ovarian failure by transplantation of a small part of her frozen/thawed ovarian tissue. Eur J Cancer. 2013;49:911–4.PubMedCrossRef
2.
Zurück zum Zitat Greve T, Timmermans Wielenga V, Grauslund M, Sørensen N, Christiansen DB, Rosendahl M, et al. Ovarian tissue cryopreserved for fertility preservation from patients with Ewing or other sarcomas appear to have no tumor cell contamination. Eur J Cancer. 2013;49:1932–8.PubMedCrossRef Greve T, Timmermans Wielenga V, Grauslund M, Sørensen N, Christiansen DB, Rosendahl M, et al. Ovarian tissue cryopreserved for fertility preservation from patients with Ewing or other sarcomas appear to have no tumor cell contamination. Eur J Cancer. 2013;49:1932–8.PubMedCrossRef
3.
Zurück zum Zitat Abir R, Feinmesser M, Yaniv I, et al. Occasional involvement of the ovary in Ewing sarcoma. Hum Reprod. 2010;25:1708–12.PubMedCrossRef Abir R, Feinmesser M, Yaniv I, et al. Occasional involvement of the ovary in Ewing sarcoma. Hum Reprod. 2010;25:1708–12.PubMedCrossRef
4.
Zurück zum Zitat Sørensen SD, Greve T, Timmermans Wielenga V, Wallace WHB, Yding Andersen C. Safety considerations for transplanting frozen/thawed ovarian tissue to restore fertility in patients who have recovered from Ewing sarcoma. Future Oncol. 2014;10:277–83.PubMedCrossRef Sørensen SD, Greve T, Timmermans Wielenga V, Wallace WHB, Yding Andersen C. Safety considerations for transplanting frozen/thawed ovarian tissue to restore fertility in patients who have recovered from Ewing sarcoma. Future Oncol. 2014;10:277–83.PubMedCrossRef
5.
Zurück zum Zitat Rosendahl M, Greve T, Yding Andersen C. The safety of transplanting cryopreserved ovarian tissue in cancer patients: a review of the literature. J Assist Reprod Genet. 2013;30:11–24.PubMedCentralPubMedCrossRef Rosendahl M, Greve T, Yding Andersen C. The safety of transplanting cryopreserved ovarian tissue in cancer patients: a review of the literature. J Assist Reprod Genet. 2013;30:11–24.PubMedCentralPubMedCrossRef
Metadaten
Titel
No malignancy detected in surplus ovarian tissue from a former Ewing sarcoma patient who experienced relapse four years after being grafted with frozen/thawed ovarian tissue
verfasst von
Claus Yding Andersen
Erik Ernst
Steen Bærentzen
Niels H. Birkebæk
Niels Clausen
Publikationsdatum
01.11.2014
Verlag
Springer US
Erschienen in
Journal of Assisted Reproduction and Genetics / Ausgabe 11/2014
Print ISSN: 1058-0468
Elektronische ISSN: 1573-7330
DOI
https://doi.org/10.1007/s10815-014-0357-2

Weitere Artikel der Ausgabe 11/2014

Journal of Assisted Reproduction and Genetics 11/2014 Zur Ausgabe

Update Gynäkologie

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert – ganz bequem per eMail.