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Erschienen in: Journal of Assisted Reproduction and Genetics 6/2017

25.03.2017 | Review

Free radical and superoxide reactivity detection in semen quality assessment: past, present, and future

verfasst von: Jaime Gosalvez, Eva Tvrda, Ashok Agarwal

Erschienen in: Journal of Assisted Reproduction and Genetics | Ausgabe 6/2017

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Abstract

Oxidative stress is a well-established cause of male infertility, with reactive oxygen species (ROS) impairing sperm production, motility, membrane, and DNA integrity. Currently, most clinics do not test infertile patients for the imbalance between ROS generation and the ability of the antioxidants to scavenge them, although there is a clear need for andrology laboratories to be able to identify and/or quantify seminal oxidative stress. As such there is a clinical urgency for an inexpensive and easy-to-perform assay able to identify oxidative stress in semen. The aim of this review is to provide information on the currently available methods to assess and quantify ROS and particularly superoxide in male reproductive cells, tissues, and fluids which may have a significant clinical utility in identifying men with impaired fertility associated with oxidative stress. Through a deeper understanding of oxidative stress and its assessment options, clinical andrology labs may better assist patients to achieve increased rates of fertility and pregnancy.
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Metadaten
Titel
Free radical and superoxide reactivity detection in semen quality assessment: past, present, and future
verfasst von
Jaime Gosalvez
Eva Tvrda
Ashok Agarwal
Publikationsdatum
25.03.2017
Verlag
Springer US
Erschienen in
Journal of Assisted Reproduction and Genetics / Ausgabe 6/2017
Print ISSN: 1058-0468
Elektronische ISSN: 1573-7330
DOI
https://doi.org/10.1007/s10815-017-0912-8

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