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Journal of Assisted Reproduction and Genetics

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24.03.2018 | Fertility Preservation

Outcome of immature oocytes collection of 119 cancer patients during ovarian tissue harvesting for fertility preservation

verfasst von: Alon Kedem, Gil M. Yerushalmi, Masha Brengauz, Hila Raanani, Raoul Orvieto, Ariel Hourvitz, Dror Meirow

Erschienen in: Journal of Assisted Reproduction and Genetics | Ausgabe 5/2018

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Abstract

Purpose

Few clinical options for fertility preservation are available to females with cancer, and data about clinical outcomes is limited. Potential supplementary approaches to fertility preservation include retrieval of immature oocytes followed by in vitro maturation (IVM) and storage. The aim of this study was to evaluate post-thawing outcomes of immature oocytes collected both by transvaginal aspiration and from excised ovarian tissue.

Methods

We conducted a retrospective cohort study of patients treated in a single tertiary center. We reviewed the records of 119 cancer patients who underwent ovarian tissue cryopreservation and immature oocyte harvesting for fertility preservation. All embryos and oocytes that were frozen and thawed were included in the study. Post-thawing outcomes were evaluated.

Results

Thirty-five stored embryos from eight patients were thawed. Twenty-nine embryos survived (82% survival rate) and were transferred. Six oocytes were thawed, two oocytes survived, and no oocytes were fertilized. Only one PCOS patient became pregnant, resulting in the normal delivery of a healthy baby.

Conclusions

Although a relatively high number of mature oocytes and embryos can be stored with the combined procedure, the limited rate of pregnancies represents a poor reproductive outcome. Therefore, this approach should be reserved for special groups with limited options.

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Titel: Outcome of immature oocytes collection of 119 cancer patients during ovarian tissue harvesting for fertility preservation
verfasst von: Alon Kedem
Gil M. Yerushalmi
Masha Brengauz
Hila Raanani
Raoul Orvieto
Ariel Hourvitz
Dror Meirow
Publikationsdatum: 24.03.2018
Verlag: Springer US
Erschienen in: Journal of Assisted Reproduction and Genetics / Ausgabe 5/2018
Print ISSN: 1058-0468
Elektronische ISSN: 1573-7330
DOI: https://doi.org/10.1007/s10815-018-1153-1

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Outcome of immature oocytes collection of 119 cancer patients during ovarian tissue harvesting for fertility preservation

Abstract

Purpose

Methods

Results

Conclusions

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Abstract

Purpose

Methods

Results

Conclusions

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