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Erschienen in: Journal of Clinical Immunology 4/2007

01.07.2007

Host Innate Immune Response to Mycobacterium tuberculosis

verfasst von: Kamlesh Bhatt, Padmini Salgame

Erschienen in: Journal of Clinical Immunology | Ausgabe 4/2007

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Abstract

This review focuses on recent progress in our understanding of Mycobacterium tuberculosis survival in macrophages, the interaction of M. tuberculosis with Toll-like receptors (TLRs) and the establishment of the link between innate and adaptive immunity, and TLRs and interferon-γ-mediated antimicrobial pathways in macrophages. We also propose a paradigm that TLR2 signaling regulates the magnitude of the host Th1 response leading to either M. tuberculosis persistence and latent infection or replication and disease.
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Metadaten
Titel
Host Innate Immune Response to Mycobacterium tuberculosis
verfasst von
Kamlesh Bhatt
Padmini Salgame
Publikationsdatum
01.07.2007
Erschienen in
Journal of Clinical Immunology / Ausgabe 4/2007
Print ISSN: 0271-9142
Elektronische ISSN: 1573-2592
DOI
https://doi.org/10.1007/s10875-007-9084-0

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