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Journal of Clinical Immunology

Erschienen in:

01.11.2008

TGF-β and Regulatory T Cell in Immunity and Autoimmunity

verfasst von: Yisong Y. Wan, Richard A. Flavell

Erschienen in: Journal of Clinical Immunology | Ausgabe 6/2008

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Abstract

Introduction

The immune response is controlled by several inhibitory mechanisms. These mechanisms include regulatory T cells, which exist in multiple classes. Notable among these are Foxp3-expressing regulatory T cells (Treg), NKT cells, and Tr1 cells. Common to these mechanisms are inhibitory cytokines such as interleukin-10 and transforming growth factor-beta (TGF-β). TGF-β and Foxp3-expressing Treg cells are critical in maintaining self-tolerance and immune homeostasis.

Discussions

The immune suppressive functions of TGF-β and Treg cells are widely acknowledged and extensively studied. Nonetheless, recent studies revealed the positive roles for TGF-β and Treg cells in shaping the immune system and the inflammatory responses. In this paper, we will discuss the role of these mechanisms in the control of immunity and autoimmunity and the mechanisms that underlie how these molecules control these responses.

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Titel: TGF-β and Regulatory T Cell in Immunity and Autoimmunity
verfasst von: Yisong Y. Wan
Richard A. Flavell
Publikationsdatum: 01.11.2008
Verlag: Springer US
Erschienen in: Journal of Clinical Immunology / Ausgabe 6/2008
Print ISSN: 0271-9142
Elektronische ISSN: 1573-2592
DOI: https://doi.org/10.1007/s10875-008-9251-y

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TGF-β and Regulatory T Cell in Immunity and Autoimmunity

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