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Journal of Clinical Immunology

Erschienen in:

01.03.2010

The IL-17 Family Cytokines in Immunity and Disease

verfasst von: Rajita Pappu, Vladimir Ramirez-Carrozzi, Naruhisa Ota, Wenjun Ouyang, Yan Hu

Erschienen in: Journal of Clinical Immunology | Ausgabe 2/2010

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Abstract

Introduction

Accumulating evidence suggests that the interleukin (IL)-17 cytokines are major players in the immune response to foreign pathogens. In addition, the pathogeneses of a number of inflammatory diseases have been linked to uncontrolled expression of these cytokine pathways.

Discussion

Genetic and biochemical analyses have elucidated the cellular and molecular events triggered by these proteins during an inflammatory response. While significant efforts have been placed on understanding the functions of IL-17A, IL-17F, and IL-17E, the significance of the other family members, IL-17B−D, in inflammation remains to be determined.

Conclusion

This review will focus on the cellular sources, target cell/receptors that are utilized by these cytokines to control pathogenesis, and the therapeutic potential of targeting these pathways to treat inflammatory disorders.

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Titel: The IL-17 Family Cytokines in Immunity and Disease
verfasst von: Rajita Pappu
Vladimir Ramirez-Carrozzi
Naruhisa Ota
Wenjun Ouyang
Yan Hu
Publikationsdatum: 01.03.2010
Verlag: Springer US
Erschienen in: Journal of Clinical Immunology / Ausgabe 2/2010
Print ISSN: 0271-9142
Elektronische ISSN: 1573-2592
DOI: https://doi.org/10.1007/s10875-010-9369-6

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The IL-17 Family Cytokines in Immunity and Disease

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Introduction

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