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Erschienen in:

01.04.2011

Gain and Loss of T Cell Subsets in Old Age—Age-Related Reshaping of the T Cell Repertoire

verfasst von: Christoph R. Arnold, Juliane Wolf, Stefan Brunner, Dietmar Herndler-Brandstetter, Beatrix Grubeck-Loebenstein

Erschienen in: Journal of Clinical Immunology | Ausgabe 2/2011

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Abstract

The immune system is affected by the aging process and undergoes significant age-related changes, termed immunosenescence. Different T cell subsets are affected by this process. Alterations within the bone marrow and thymus lead to a shift in the composition of the T cell repertoire from naïve to antigen-experienced T cells, thereby compromising the diversity of the T cell pool. Additional infection with latent pathogens such as cytomegalovirus aggravates this process. In this review, we focus on the major age-related changes that occur in the naïve and the antigen-experienced T cell population. We discuss the mechanisms responsible for the generation and maintenance of these subsets and how age-related changes can be delayed or prevented by clinical interventions.

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Titel: Gain and Loss of T Cell Subsets in Old Age—Age-Related Reshaping of the T Cell Repertoire
verfasst von: Christoph R. Arnold
Juliane Wolf
Stefan Brunner
Dietmar Herndler-Brandstetter
Beatrix Grubeck-Loebenstein
Publikationsdatum: 01.04.2011
Verlag: Springer US
Erschienen in: Journal of Clinical Immunology / Ausgabe 2/2011
Print ISSN: 0271-9142
Elektronische ISSN: 1573-2592
DOI: https://doi.org/10.1007/s10875-010-9499-x

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Gain and Loss of T Cell Subsets in Old Age—Age-Related Reshaping of the T Cell Repertoire

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