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01.02.2015 | CME Review

Coronin-1A: Immune Deficiency in Humans and Mice

verfasst von: Divya Punwani, Barry Pelz, Jason Yu, Nicoleta C. Arva, Kristian Schafernak, Karly Kondratowicz, Melanie Makhija, Jennifer M. Puck

Erschienen in: Journal of Clinical Immunology | Ausgabe 2/2015

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The study of human primary immunodeficiencies (PIDs) has identified factors critical for the development and function of the immune system [1]. While typical severe combined immunodeficiency (SCID) in humans is defined by a profound block in T lymphocyte production, with or without associated B and NK lymphocyte defects, more heterogeneous combined immunodeficiency (CID) disorders arise from gene defects that allow T lymphocytes to mature, but hinder their survival, release from the thymus into the periphery, or effector functions [2]. Individuals with CID may have both impairment of immune responses and defects in immune regulation; thus they may experience severe, recurrent and opportunistic infections as well as autoimmune disorders [3, 4]. …

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Titel: Coronin-1A: Immune Deficiency in Humans and Mice
verfasst von: Divya Punwani
Barry Pelz
Jason Yu
Nicoleta C. Arva
Kristian Schafernak
Karly Kondratowicz
Melanie Makhija
Jennifer M. Puck
Publikationsdatum: 01.02.2015
Verlag: Springer US
Erschienen in: Journal of Clinical Immunology / Ausgabe 2/2015
Print ISSN: 0271-9142
Elektronische ISSN: 1573-2592
DOI: https://doi.org/10.1007/s10875-015-0130-z

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