nach oben

Journal of Genetic Counseling

Erschienen in:

01.04.2014 | Review Article

Specific Psychosocial Issues of Individuals Undergoing Genetic Counseling for Cancer – A Literature Review

verfasst von: Willem Eijzenga, Daniela EE Hahn, Neil K Aaronson, Irma Kluijt, Eveline MA Bleiker

Erschienen in: Journal of Genetic Counseling | Ausgabe 2/2014

Einloggen, um Zugang zu erhalten

Abstract

Approximately 25 % of individuals undergoing genetic counseling for cancer experiences clinically relevant levels of distress, anxiety and/or depression. However, these general psychological outcomes that are used in many studies do not provide detailed information on the specific psychosocial problems experienced by counselees. The aim of this review was to investigate the specific psychosocial issues encountered by individuals undergoing genetic counseling for cancer, and to identify overarching themes across these issues. A literature search was performed, using four electronic databases (PubMed, PsychInfo, CINAHL and Embase). Papers published between January 2000 and January 2013 were selected using combinations, and related indexing terms of the keywords: ‘genetic counseling’, ‘psychology’ and ‘cancer’. In total, 25 articles met our inclusion criteria. We identified the specific issues addressed by these papers, and used meta-ethnography to identify the following six overarching themes: coping with cancer risk, practical issues, family issues, children-related issues, living with cancer, and emotions. A large overlap in the specific issues and themes was found between these studies, suggesting that research on specific psychosocial problems within genetic counseling has reached a point of saturation. As a next step, efforts should be made to detect and monitor these problems of counselees at an early stage within the genetic counseling process.

Aktan-Collan, K. I., Kaariainen, H. A., Kolttola, E. M., Pylvanainen, K., Jarvinen, H. J., Haukkala, A. H., et al. (2011). Sharing genetic risk with next generation: mutation-positive parents’ communication with their offspring in Lynch Syndrome. Familial Cancer, 10, 43–50.PubMedCrossRef

Appleton, S., Fry, A., Rees, G., Rush, R., & Cull, A. (2000). Psychosocial effects of living with an increased risk of breast cancer: an exploratory study using telephone focus groups. Psycho-Oncology, 9, 511–521.PubMedCrossRef

Atkins, S., Lewin, S., Smith, H., Engel, M., Fretheim, A., & Volmink, J. (2008). Conducting a meta-ethnography of qualitative literature: lessons learnt. BMC Medical Research Methodology, 8, 21.PubMedCentralPubMedCrossRef

Bakos, A. D., Hutson, S. P., Loud, J. T., Peters, J. A., Giusti, R. M., & Greene, M. H. (2008). BRCA mutation-negative women from hereditary breast and ovarian cancer families: a qualitative study of the BRCA-negative experience. Health Expectations, 11, 220–231.PubMedCentralPubMedCrossRef

Barnett-Page, E., & Thomas, J. (2009). Methods for the synthesis of qualitative research: a critical review. BMC.Med.Res.Methodol, 9, 59.PubMedCentralPubMedCrossRef

Bennett, P., Parsons, E., Brain, K., & Hood, K. (2010). Long-term cohort study of women at intermediate risk of familial breast cancer: experiences of living at risk. Psycho-Oncology, 19, 390–398.PubMedCrossRef

Bjorvatn, C., Eide, G. E., Hanestad, B. R., Oyen, N., Havik, O. E., Carlsson, A., et al. (2007). Risk perception, worry and satisfaction related to genetic counseling for hereditary cancer. Journal of Genetic Counseling, 16, 211–222.PubMedCrossRef

Bjorvatn, C., Eide, G. E., Hanestad, B. R., & Havik, O. E. (2008). Anxiety and depression among subjects attending genetic counseling for hereditary cancer. Patient Education and Counseling, 71, 234–243.PubMedCrossRef

Bonadona, V., Saltel, P., Desseigne, F., Mignotte, H., Saurin, J. C., Wang, Q., et al. (2002). Cancer patients who experienced diagnostic genetic testing for cancer susceptibility: reactions and behavior after the disclosure of a positive test result. Cancer Epidemiology, Biomarkers & Prevention, 11, 97–104.

Bradbury, A. R., Patrick-Miller, L., Egleston, B. L., Olopade, O. I., Daly, M. B., Moore, C. W., et al. (2012). When parents disclose BRCA1/2 test results: their communication and perceptions of offspring response. Cancer, 118, 3417–3425.PubMedCentralPubMedCrossRef

Brady, M. J., Cella, D. F., Mo, F., Bonomi, A. E., Tulsky, D. S., Lloyd, S. R., et al. (1997). Reliability and validity of the Functional Assessment of Cancer Therapy-Breast quality-of-life instrument. Journal of Clinical Oncology, 15, 974–986.PubMed

Braithwaite, D., Emery, J., Walter, F., Prevost, A. T., & Sutton, S. (2006). Psychological impact of genetic counseling for familial cancer: a systematic review and meta-analysis. Familial Cancer, 5, 61–75.PubMedCrossRef

Britten, N., Campbell, R., Pope, C., Donovan, J., Morgan, M., & Pill, R. (2002). Using meta ethnography to synthesise qualitative research: a worked example. Journal of Health Services Research & Policy, 7, 209–215.CrossRef

Broadstock, M., Michie, S., & Marteau, T. (2000). Psychological consequences of predictive genetic testing: a systematic review. European Journal of Human Genetics, 8, 731–738.PubMedCrossRef

Butow, P. N., Lobb, E. A., Meiser, B., Barratt, A., & Tucker, K. M. (2003). Psychological outcomes and risk perception after genetic testing and counselling in breast cancer: a systematic review. The Medical Journal of Australia, 178, 77–81.PubMed

Campbell, R., Pound, P., Morgan, M., Daker-White, G., Britten, N., Pill, R., et al. (2011). Evaluating meta-ethnography: systematic analysis and synthesis of qualitative research. Health Technology Assessment, 15, 1–164.PubMed

Carlsson, C., & Nilbert, M. (2007). Living with hereditary non-polyposis colorectal cancer; experiences from and impact of genetic testing. Journal of Genetic Counseling, 16, 811–820.PubMedCrossRef

Cheung, E. L., Olson, A. D., Yu, T. M., Han, P. Z., & Beattie, M. S. (2010). Communication of BRCA results and family testing in 1,103 high-risk women. Cancer Epidemiology, Biomarkers & Prevention, 19, 2211–2219.CrossRef

Claes, E., Evers-Kiebooms, G., Boogaerts, A., Decruyenaere, M., Denayer, L., & Legius, E. (2003). Communication with close and distant relatives in the context of genetic testing for hereditary breast and ovarian cancer in cancer patients. American Journal of Medical Genetics. Part A, 116A, 11–19.PubMedCrossRef

Coyne, J. C., Benazon, N. R., Gaba, C. G., Calzone, K., & Weber, B. L. (2000). Distress and psychiatric morbidity among women from high-risk breast and ovarian cancer families. Journal of Consulting and Clinical Psychology, 68, 864–874.PubMedCrossRef

Crump, R. J., Fitzgerald, R. P., & Legge, M. (2010). ‘Going-to-have-cancerness’: a study of living with increased risk of BRCA1 and BRCA2 mutations for six South Island women. Journal of Primary Health Care, 2, 311–317.PubMed

d’Agincourt-Canning, L. (2006). A gift or a yoke? Women’s and men’s responses to genetic risk information from BRCA1 and BRCA2 testing. Clinical Genetics, 70, 462–472.PubMedCrossRef

Di Prospero, L. S., Seminsky, M., Honeyford, J., Doan, B., Franssen, E., Meschino, W., et al. (2001). Psychosocial issues following a positive result of genetic testing for BRCA1 and BRCA2 mutations: findings from a focus group and a needs-assessment survey. CMAJ, 164, 1005–1009.PubMedCentralPubMed

Dixon-Woods, M., Agarwal, S., Jones, D., Young, B., & Sutton, A. (2005). Synthesising qualitative and quantitative evidence: a review of possible methods. Journal of Health Services Research & Policy, 10, 45–53.CrossRef

Douglas, H. A., Hamilton, R. J., & Grubs, R. E. (2009). The effect of BRCA gene testing on family relationships: A thematic analysis of qualitative interviews. Journal of Genetic Counseling, 18, 418–435.PubMedCrossRef

Douma, K. F., Aaronson, N. K., Vasen, H. F., & Bleiker, E. M. (2008). Psychosocial issues in genetic testing for familial adenomatous polyposis: a review of the literature. Psycho-Oncology, 17, 737–745.PubMedCrossRef

Douma, K. F., Aaronson, N. K., Vasen, H. F., Gerritsma, M. A., Gundy, C. M., Janssen, E. P., et al. (2010). Psychological distress and use of psychosocial support in familial adenomatous polyposis. Psycho-Oncology, 19, 289–298.PubMedCrossRef

Duncan, R. E., Gillam, L., Savulescu, J., Williamson, R., Rogers, J. G., & Delatycki, M. B. (2008). “You’re one of us now”: young people describe their experiences of predictive genetic testing for Huntington disease (HD) and familial adenomatous polyposis (FAP). American Journal of Medical Genetics. Part C, Seminars in Medical Genetics, 148C, 47–55.PubMedCrossRef

Ersig, A. L., Williams, J. K., Hadley, D. W., & Koehly, L. M. (2009). Communication, encouragement, and cancer screening in families with and without mutations for hereditary nonpolyposis colorectal cancer: a pilot study. Genetics in Medicine, 11, 728–734.PubMedCentralPubMedCrossRef

Esplen, M. J., Madlensky, L., Aronson, M., Rothenmund, H., Gallinger, S., Butler, K., et al. (2007). Colorectal cancer survivors undergoing genetic testing for hereditary non-polyposis colorectal cancer: motivational factors and psychosocial functioning. Clinical Genetics, 72, 394–401.PubMedCrossRef

Frost, C. J., Venne, V., Cunningham, D., & Gerritsen-McKane, R. (2004). Decision making with uncertain information: learning from women in a high risk breast cancer clinic. Journal of Genetic Counseling, 13, 221–236.PubMedCrossRef

Gallacher, K., Jani, B., Morrison, D., Macdonald, S., Blane, D., Erwin, P., et al. (2013). Qualitative Systematic Reviews of Treatment Burden in Stroke, Heart Failure and Diabetes - Methodological Challenges and Solutions. BMC Medical Research Methodology, 13, 10.PubMedCentralPubMedCrossRef

Garber, J. E., & Offit, K. (2005). Hereditary cancer predisposition syndromes. Journal of Clinical Oncology, 23, 276–292.PubMedCrossRef

Hallowell, N., Foster, C., Eeles, R., Ardern-Jones, A., & Watson, M. (2004). Accommodating risk: responses to BRCA1/2 genetic testing of women who have had cancer. Social Science & Medicine, 59, 553–565.CrossRef

Hallowell, N., Ardern-Jones, A., Eeles, R., Foster, C., Lucassen, A., Moynihan, C., et al. (2005). Communication about genetic testing in families of male BRCA1/2 carriers and non-carriers: patterns, priorities and problems. Clinical Genetics, 67, 492–502.PubMedCrossRef

Hallowell, N., Arden-Jones, A., Eeles, R., Foster, C., Lucassen, A., Moynihan, C., et al. (2006). Guilt, blame and responsibility: men’s understanding of their role in the transmission of BRCA1/2 mutations within their family. Sociology of Health & Illness, 28, 969–988.CrossRef

Hamilton, R., & Hurley, K. E. (2010). Conditions and consequences of a BRCA mutation in young, single women of childbearing age. Oncology Nursing Forum, 37, 627–634.PubMedCrossRef

Hamilton, J. G., Lobel, M., & Moyer, A. (2009a). Emotional distress following genetic testing for hereditary breast and ovarian cancer: a meta-analytic review. Health Psychology, 28, 510–518.PubMedCentralPubMedCrossRef

Hamilton, R., Williams, J. K., Skirton, H., & Bowers, B. J. (2009b). Living with genetic test results for hereditary breast and ovarian cancer. Journal of Nursing Scholarship, 41, 276–283.PubMedCrossRef

Kasparian, N. A., Wakefield, C. E., & Meiser, B. (2007). Assessment of psychosocial outcomes in genetic counseling research: an overview of available measurement scales. Journal of Genetic Counseling, 16, 693–712.PubMedCrossRef

Kasparian, N. A., Meiser, B., Butow, P. N., Simpson, J. M., & Mann, G. J. (2008). Predictors of psychological distress among individuals with a strong family history of malignant melanoma. Clinical Genetics, 73, 121–131.PubMedCrossRef

Keller, M., Jost, R., Haunstetter, C. M., Sattel, H., Schroeter, C., Bertsch, U., et al. (2008). Psychosocial outcome following genetic risk counselling for familial colorectal cancer. A comparison of affected patients and family members. Clinical Genetics, 74, 414–424.PubMedCrossRef

Kenen, R., Ardern-Jones, A., & Eeles, R. (2003). Living with chronic risk: healthy women with a family history of breast/ovarian cancer. Health, Risk & Society, 5, 315–331.CrossRef

Lammens, C. R., Aaronson, N. K., Wagner, A., Sijmons, R. H., Ausems, M. G., Vriends, A. H., et al. (2010). Genetic testing in Li-Fraumeni syndrome: uptake and psychosocial consequences. Journal of Clinical Oncology, 28, 3008–3014.PubMedCrossRef

Landsbergen, K. M., Prins, J. B., Brunner, H. G., & Hoogerbrugge, N. (2009a). Genetic testing offered directly after the diagnosis of colorectal cancer: a pilot study on the reactions of patients. Genetic Counseling, 20, 317–325.PubMed

Landsbergen, K. M., Prins, J. B., Brunner, H. G., Kraaimaat, F. W., & Hoogerbrugge, N. (2009b). Genetic testing for Lynch syndrome in the first year of colorectal cancer: a review of the psychological impact. Familial Cancer, 8, 325–337.PubMedCentralPubMedCrossRef

Lim, J., Macluran, M., Price, M., Bennett, B., & Butow, P. (2004). Short- and long-term impact of receiving genetic mutation results in women at increased risk for hereditary breast cancer. Journal of Genetic Counseling, 13, 115–133.PubMedCrossRef

Lindor, N. M., McMaster, M. L., Lindor, C. J., & Greene, M. H. (2008). Concise handbook of familial cancer susceptibility syndromes - second edition. Journal of the National Cancer Institute. Monographs, 1–93.

Lodder, L., Frets, P. G., Trijsburg, R. W., Tibben, A., Meijers-Heijboer, E. J., Duivenvoorden, H. J., et al. (2001). Men at risk of being a mutation carrier for hereditary breast/ovarian cancer: an exploration of attitudes and psychological functioning during genetic testing. European Journal of Human Genetics, 9, 492–500.PubMedCrossRef

MacDonald, D. J., Sarna, L., Weitzel, J. N., & Ferrell, B. (2010). Women’s perceptions of the personal and family impact of genetic cancer risk assessment: focus group findings. Journal of Genetic Counseling, 19, 148–160.PubMedCrossRef

Maheu, C. (2009). Implications of living with a strong family history of breast cancer. Canadian Journal of Nursing Research, 41, 100–112.PubMed

McCann, S., MacAuley, D., Barnett, Y., Bunting, B., Bradley, A., Jeffers, L., et al. (2009). Family communication, genetic testing and colonoscopy screening in hereditary non-polyposis colon cancer: a qualitative study. Psycho-Oncology, 18, 1208–1215.PubMedCrossRef

Meiser, B. (2005). Psychological impact of genetic testing for cancer susceptibility: an update of the literature. Psycho-Oncology, 14, 1060–1074.PubMedCrossRef

Meiser, B., Butow, P., Friedlander, M., Barratt, A., Schnieden, V., Watson, M., et al. (2002). Psychological impact of genetic testing in women from high-risk breast cancer families. European Journal of Cancer, 38, 2025–2031.PubMedCrossRef

Meiser, B., Tucker, K., Friedlander, M., Barlow-Stewart, K., Lobb, E., Saunders, C., et al. (2008). Genetic counselling and testing for inherited gene mutations in newly diagnosed patients with breast cancer: a review of the existing literature and a proposed research agenda. Breast Cancer Research, 10, 216.PubMedCentralPubMedCrossRef

Mellon, S., Gold, R., Janisse, J., Cichon, M., Tainsky, M. A., Simon, M. S., et al. (2008). Risk perception and cancer worries in families at increased risk of familial breast/ovarian cancer. Psycho-Oncology, 17, 756–766.PubMedCentralPubMedCrossRef

Mendes, A. F., Santos, T. A., & Sousa, L. (2011). Experiencing genetic counselling for hereditary cancers: the client’s perspective. European Journal of Cancer Care (Engl), 20, 204–211.CrossRef

Mireskandari, S., Sangster, J., Meiser, B., Thewes, B., Groombridge, C., Spigelman, A., et al. (2009). Psychosocial impact of familial adenomatous polyposis on young adults: a qualitative study. Journal of Genetic Counseling, 18, 409–417.PubMedCrossRef

Noblit, G. W., & Hare, R. D. (1988). Meta-Ethnography: Synthesizing Qualitative Studies. London: Sage.

Pasacreta, J. V. (2003). Psychosocial issues associated with genetic testing for breast and ovarian cancer risk: an integrative review. Cancer Investigation, 21, 588–623.PubMedCrossRef

Patenaude, A. F., Dorval, M., DiGianni, L. S., Schneider, K. A., Chittenden, A., & Garber, J. E. (2006). Sharing BRCA1/2 test results with first-degree relatives: factors predicting who women tell. Journal of Clinical Oncology, 24, 700–706.PubMedCrossRef

Payne, K., Nicholls, S., McAllister, M., Macleod, R., Donnai, D., & Davies, L. M. (2008). Outcome measurement in clinical genetics services: a systematic review of validated measures. Value in Health, 11, 497–508.PubMedCrossRef

Pound, P., Britten, N., Morgan, M., Yardley, L., Pope, C., Daker-White, G., et al. (2005). Resisting medicines: a synthesis of qualitative studies of medicine taking. Social Science & Medicine, 61, 133–155.CrossRef

Resta, R., Biesecker, B. B., Bennett, R. L., Blum, S., Hahn, S. E., Strecker, M. N., et al. (2006). A new definition of Genetic Counseling: National Society of Genetic Counselors’ Task Force report. Journal of Genetic Counseling, 15, 77–83.PubMedCrossRef

Riley, B. D., Culver, J. O., Skrzynia, C., Senter, L. A., Peters, J. A., Costalas, J. W., et al. (2012). Essential elements of genetic cancer risk assessment, counseling, and testing: updated recommendations of the National Society of Genetic Counselors. Journal of Genetic Counseling, 21, 151–161.PubMedCrossRef

Ring, N., Jepson, R., & Ritchie, K. (2011). Methods of synthesizing qualitative research studies for health technology assessment. International Journal of Technology Assessment in Health Care, 27, 384–390.PubMedCrossRef

Schlich-Bakker, K. J., ten Kroode, H. F., & Ausems, M. G. (2006a). A literature review of the psychological impact of genetic testing on breast cancer patients. Patient Education and Counseling, 62, 13–20.PubMedCrossRef

Schlich-Bakker, K. J., Warlam-Rodenhuis, C. C., van Echtelt, J., van den Bout, J., Ausems, M. G., & ten Kroode, H. F. (2006b). Short term psychological distress in patients actively approached for genetic counselling after diagnosis of breast cancer. European Journal of Cancer, 42, 2722–2728.PubMedCrossRef

Sprangers, M. A., te Velde, A., & Aaronson, N. K. (1999). The construction and testing of the EORTC colorectal cancer-specific quality of life questionnaire module (QLQ-CR38). European Organization for Research and Treatment of Cancer Study Group on Quality of Life. European Journal of Cancer, 35, 238–247.PubMedCrossRef

Street, R. L., Jr., Makoul, G., Arora, N. K., & Epstein, R. M. (2009). How does communication heal? Pathways linking clinician-patient communication to health outcomes. Patient Education and Counseling, 74, 295–301.PubMedCrossRef

Stromsvik, N., Raheim, M., Oyen, N., & Gjengedal, E. (2009). Men in the women’s world of hereditary breast and ovarian cancer–a systematic review. Familial Cancer, 8, 221–229.PubMedCrossRef

Stromsvik, N., Raheim, M., Oyen, N., Engebretsen, L. F., & Gjengedal, E. (2010). Stigmatization and male identity: Norwegian males’ experience after identification as BRCA1/2 mutation carriers. Journal of Genetic Counseling, 19, 360–370.PubMedCrossRef

Stromsvik, N., Raheim, M., & Gjengedal, E. (2011). Cancer worry among Norwegian male BRCA1/2 mutation carriers. Familial Cancer, 10, 597–603.PubMedCentralPubMedCrossRef

Stroup, A. M., & Smith, K. R. (2007). Familial effects of BRCA1 genetic mutation testing: changes in perceived family functioning. Cancer Epidemiology, Biomarkers & Prevention, 16, 135–141.CrossRef

Tercyak, K. P., Peshkin, B. N., DeMarco, T. A., Brogan, B. M., & Lerman, C. (2002). Parent–child factors and their effect on communicating BRCA1/2 test results to children. Patient Education and Counseling, 47, 145–153.PubMedCrossRef

Tercyak, K. P., Peshkin, B. N., DeMarco, T. A., Patenaude, A. F., Schneider, K. A., Garber, J. E., et al. (2007). Information needs of mothers regarding communicating BRCA1/2 cancer genetic test results to their children. Genetic Testing, 11, 249–255.PubMedCentralPubMedCrossRef

Trepanier, A., Ahrens, M., McKinnon, W., Peters, J., Stopfer, J., Grumet, S. C., et al. (2004). Genetic cancer risk assessment and counseling: recommendations of the national society of genetic counselors. Journal of Genetic Counseling, 13, 83–114.PubMedCrossRef

Turner-Cobb, J. M., Bloor, L. E., Whittemore, A. S., West, D., & Spiegel, D. (2006). Disengagement and social support moderate distress among women with a family history of breast cancer. The Breast Journal, 12, 7–15.PubMedCrossRef

Vadaparampil, S. T., Miree, C. A., Wilson, C., & Jacobsen, P. B. (2006). Psychosocial and behavioral impact of genetic counseling and testing. Breast Disease, 27, 97–108.PubMed

Vadaparampil, S. T., Quinn, G. P., Brzosowicz, J., & Miree, C. A. (2008). Experiences of genetic counseling for BRCA1/2 among recently diagnosed breast cancer patients: a qualitative inquiry. Journal of Psychosocial Oncology, 26, 33–52.PubMedCrossRef

Vos, J., van Asperen, C. J., Oosterwijk, J. C., Menko, F. H., Collee, M . J., Garcia, E. G. et al. (2013). The counselees’ self-reported request for psychological help in genetic counseling for hereditary breast/ovarian cancer: not only psychopathology matters. Psycho-Oncology, 22, 902–910.

Wagner Costalas, J., Itzen, M., Malick, J., Babb, J. S., Bove, B., Godwin, A. K., et al. (2003). Communication of BRCA1 and BRCA2 results to at-risk relatives: a cancer risk assessment program’s experience. American Journal of Medical Genetics. Part C, Seminars in Medical Genetics, 119C, 11–18.PubMedCrossRef

Walter, F. M., Emery, J., Braithwaite, D., & Marteau, T. M. (2004). Lay understanding of familial risk of common chronic diseases: a systematic review and synthesis of qualitative research. Annals of Family Medicine, 2, 583–594.PubMedCentralPubMedCrossRef

Titel: Specific Psychosocial Issues of Individuals Undergoing Genetic Counseling for Cancer – A Literature Review
verfasst von: Willem Eijzenga
Daniela EE Hahn
Neil K Aaronson
Irma Kluijt
Eveline MA Bleiker
Publikationsdatum: 01.04.2014
Verlag: Springer US
Erschienen in: Journal of Genetic Counseling / Ausgabe 2/2014
Print ISSN: 1059-7700
Elektronische ISSN: 1573-3599
DOI: https://doi.org/10.1007/s10897-013-9649-4

Neu im Fachgebiet Gynäkologie und Geburtshilfe

23.04.2024 | Medikamente in Schwangerschaft und Stillzeit | Nachrichten

Update Gynäkologie

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert – ganz bequem per eMail.

Newsletter bestellen

Springer Medizin

Specific Psychosocial Issues of Individuals Undergoing Genetic Counseling for Cancer – A Literature Review

Abstract

Neu im Fachgebiet Gynäkologie und Geburtshilfe

ICI-Therapie in der Schwangerschaft wird gut toleriert

Weniger postpartale Depressionen nach Esketamin-Einmalgabe

Bei RSV-Impfung vor 60. Lebensjahr über Off-Label-Gebrauch aufklären!

Harnwegsinfektprophylaxe: Es geht auch ohne Antibiotika

Update Gynäkologie

Springer Medizin

Abstract

Bitte loggen Sie sich ein, um Zugang zu diesem Inhalt zu erhalten

Weitere Artikel der Ausgabe 2/2014

Psychosocial Burden of Sickle Cell Disease on Parents with an Affected Child in Cameroon

Aspirin Use is Associated with Lower Prostate Cancer Risk in Male Carriers of BRCA Mutations

A Qualitative Inquiry of the Financial Concerns of Couples Opting to Use Preimplantation Genetic Diagnosis to Prevent the Transmission of Known Genetic Disorders

‘Battling my Biology’: Psychological Effects of Genetic Testing for Risk of Weight Gain

Predictive Genetic Testing in Children: Constitutional Mismatch Repair Deficiency Cancer Predisposing Syndrome

Changes in Specialists’ Perspectives on Cancer Genetic Testing, Prophylactic Surgery and Insurance Discrimination: Then and Now

Neu im Fachgebiet Gynäkologie und Geburtshilfe

ICI-Therapie in der Schwangerschaft wird gut toleriert

Weniger postpartale Depressionen nach Esketamin-Einmalgabe

Bei RSV-Impfung vor 60. Lebensjahr über Off-Label-Gebrauch aufklären!

Harnwegsinfektprophylaxe: Es geht auch ohne Antibiotika

Update Gynäkologie