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Journal of Mammary Gland Biology and Neoplasia

Erschienen in:

01.04.2006

Preclinical Imaging of Mammary Intraepithelial Neoplasia with Positron Emission Tomography

verfasst von: Craig K. Abbey, Alexander D. Borowsky, Jeffery P. Gregg, Robert D. Cardiff, Simon R. Cherry

Erschienen in: Journal of Mammary Gland Biology and Neoplasia | Ausgabe 2/2006

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Abstract

Small-animal imaging with positron emission tomography (PET) has become a valuable tool for evaluating preclinical models of breast cancer and other diseases. In this review, we examine a number of issues related to preclinical imaging studies with PET, using transgenic models of ductal carcinoma in situ and metastasis as specific examples. We discuss imaging components such as reconstruction, normalization, and extraction of quantitative parameters. We also analyze the effect of longitudinal correlations on cohort size and present some simple statistical techniques for determining cohort sizes that may be helpful in designing preclinical imaging studies. We describe studies that are greatly facilitated by access to non-invasive imaging data including a study involving multiple endpoints and another investigating metastasis. We conclude with a brief survey of emerging approaches in small-animal PET imaging.

We use a body-centered reference in which the coronal view is perpendicular to the long axis of the body. Some preclinical studies of the brain use a different reference in which this view would be considered a horizontal view.

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Titel: Preclinical Imaging of Mammary Intraepithelial Neoplasia with Positron Emission Tomography
verfasst von: Craig K. Abbey
Alexander D. Borowsky
Jeffery P. Gregg
Robert D. Cardiff
Simon R. Cherry
Publikationsdatum: 01.04.2006
Verlag: Kluwer Academic Publishers-Plenum Publishers
Erschienen in: Journal of Mammary Gland Biology and Neoplasia / Ausgabe 2/2006
Print ISSN: 1083-3021
Elektronische ISSN: 1573-7039
DOI: https://doi.org/10.1007/s10911-006-9020-6

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Preclinical Imaging of Mammary Intraepithelial Neoplasia with Positron Emission Tomography

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