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Journal of Mammary Gland Biology and Neoplasia

Erschienen in:

13.07.2017

Monitoring In-Vivo the Mammary Gland Microstructure during Morphogenesis from Lactation to Post-Weaning Using Diffusion Tensor MRI

verfasst von: Noam Nissan, Edna Furman-Haran, Myra Shapiro-Feinberg, Dov Grobgeld, Hadassa Degani

Erschienen in: Journal of Mammary Gland Biology and Neoplasia | Ausgabe 3/2017

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Abstract

Lactation and the return to the pre-conception state during post-weaning are regulated by hormonal induced processes that modify the microstructure of the mammary gland, leading to changes in the features of the ductal / glandular tissue, the stroma and the fat tissue. These changes create a challenge in the radiological workup of breast disorder during lactation and early post-weaning. Here we present non-invasive MRI protocols designed to record in vivo high spatial resolution, T₂-weighted images and diffusion tensor images of the entire mammary gland. Advanced imaging processing tools enabled tracking the changes in the anatomical and microstructural features of the mammary gland from the time of lactation to post-weaning. Specifically, by using diffusion tensor imaging (DTI) it was possible to quantitatively distinguish between the ductal / glandular tissue distention during lactation and the post-weaning involution. The application of the T₂-weighted imaging and DTI is completely safe, non-invasive and uses intrinsic contrast based on differences in transverse relaxation rates and water diffusion rates in various directions, respectively. This study provides a basis for further in-vivo monitoring of changes during the mammary developmental stages, as well as identifying changes due to malignant transformation in patients with pregnancy associated breast cancer (PABC).

Hovey RC, Trott JF, Vonderhaar BK. Establishing a framework for the functional mammary gland: from endocrinology to morphology. J Mammary Gland Biol Neoplasia. 2002;7(1):17–38. ReviewCrossRefPubMed

Neville MC, McFadden TB, Forsyth I. Hormonal regulation of mammary differentiation and milk secretion. J Mammary Gland Biol Neoplasia. 2002;7(1):49–66.CrossRefPubMed

Kent JC. How breast feeding works. J Midwifery Women’s Heal. 2007;52:564–70.CrossRef

Neville MC, Allen JC, Archer PC, et al. Studies in human lactation: milk volume and nutrient composition during weaning and lactogenesis. Am J Clin Nutr. 1991;54:81–92.PubMed

McDaniel SM, Rumer KK, Biroc SL, et al. Remodeling of the mammary microenvironment after lactation promotes breast tumor cell metastasis. Am J Pathol. 2006;168:608–20.CrossRefPubMedPubMedCentral

Schedin P, O’Brien J, Rudolph M, Stein T, Borges V. Microenvironment of the involuting mammary gland mediates mammary cancer progression. J Mammary Gland Biol Neoplasia. 2007;12:71–82.CrossRefPubMed

Cooper A. Anatomy of the breast. London: Longman, Orme, Green, Browne and Longmans; 1840.

Ramsay DT, Kent JC, Hartmann RA, Hartmann PE. Anatomy of the lactating human breast redefined with ultrasound imaging. J Anat. 2005;206:525–34.CrossRefPubMedPubMedCentral

Gooding MJ, Finlay J, Shipley JA, Halliwell M, Duck FA. Three-dimensional ultrasound imaging of mammary ducts in lactating women: a feasibility study. J Ultrasound Med. 2010;29:95–103.CrossRefPubMed

10.

Markiewicz E, Fan X, Mustafia D, Zamoraa M, Roman BB, Jansen SA, Macleod K, Conzen SD, and Karczmara GS, High resolution 3D MRI of mouse mammary glands with intra-ductal injection of contrast media. Magn Reson Imaging. 2015; 33(1):161–165, doi:10.1016/j.mri.2014.08.035

11.

Physics of MRI: a primer, DB Plewes, W Kucharczyk - J Magn Reson Imaging 2012; 35:1038–1054. doi:10.1002/jmri.23642

12.

Santyr GE. MR imaging of the breast. Imaging and tissue characterization without intravenous contrast. Rev Magn Reson Imaging Clin N Am. 1994;2(4):673–90.

13.

Iima MD, Le Bihan MD. Clinical Intravoxel incoherent motion and diffusion MR imaging: past, present, and future. Radiology. 2016;278(1):13–32. doi:10.1148/radiol.2015150244. ReviewCrossRefPubMed

14.

Vashi R, Hooley R, Butler R, Geisel J, Philpotts L. Breast imaging of the pregnant and lactating patient: imaging modalities and pregnancy-associated breast cancer. Am J Roentgenol. 2013;200(2):321–8.CrossRef

15.

Ayyappan AP, Kulkarni S, Crystal P. Pregnancy-associated breast cancer: spectrum of imaging appearances. Br J Radiol. 2010;83(990):529–34. doi:10.1259/bjr/17982822.CrossRefPubMedPubMedCentral

16.

Turnbull LW. Dynamic contrast-enhanced MRI in the diagnosis and management of breast cancer. NMR Biomed. 2009;22(1):28–39. doi:10.1002/nbm.1273. ReviewCrossRefPubMed

17.

Moon M, Cornfeld D, Weinreb J. Dynamic contrast-enhanced breast MR imaging. Magn Reson Imaging Clin N Am. 2009;17(2):351–62. doi:10.1016/j.mric.2009.01.010. ReviewCrossRefPubMed

18.

Pinker K, Helbich TH, Morris EA. The potential of multiparametric MRI of the breast. Br J Radiol. 2017;90(1069):20160715. doi:10.1259/bjr.20160715. ReviewCrossRefPubMed

19.

Sundgren PC, Leander P. Is administration of gadolinium-based contrast media to pregnant women and small children justified? J Magn Reson Imaging. 2011;34(4):750–7. ReviewCrossRefPubMed

20.

Kanal E, Barkovich AJ, Bell C, et al. ACR guidance document on MR safe practices. J Magn Reson Imaging. 2013;37(3):501–30.CrossRefPubMed

21.

Boivin G, de Korvin B, Marion J, Duvauferrier R. Is a breast MRI possible and indicated in case of suspicion of breast cancer during lactation? Diagn Interv Imaging. 2012;93(11):823–7. doi:10.1016/j.diii.2012.05.013.CrossRefPubMed

22.

Talele AC, Slanetz PJ, Edmister WB, Yeh ED, Kopans DB. The lactating breast: MRI findings and literature review. The lactating breast: MRI findings and literature review. Breast J. 2003;9(3):237–40.CrossRefPubMed

23.

Espinosa LA, Daniel BL, Vidarsson L, Zakhour M, Ikeda DM, Herfkens RJ. The lactating breast: contrast-enhanced MR imaging of normal tissue and cancer. Radiology. 2005;237(2):429–36.CrossRefPubMed

24.

Spick C, Pinker-Domenig K, Rudas M, Helbich TH. Baltzer PA.MRI-only lesions: application of diffusion weighted imaging obviates unnecessary MR-guided breast biopsies. Eur Radiol. 2014;24(6):1204–10. doi:10.1007/s00330-014-3153-6.CrossRefPubMed

25.

Partridge SC, McDonald ES. Diffusion weighted magnetic resonance imaging of the breast: protocol optimization, interpretation, and clinical applications. Magn Reson Imaging Clin N Am. 2013;21(3):601–24. doi:10.1016/j.mric.2013.04.007. and references cited therein)CrossRefPubMedPubMedCentral

26.

Sah RG, Agarwal K, Sharma U, Parshad R, Seenu V, Jagannathan NR. Characterization of malignant breast tissue of breast cancer patients and the normal breast tissue of healthy lactating women volunteers using diffusion MRI and in vivo 1H MR spectroscopy. J Magn Reson Imaging. 2015;41:169–74.CrossRefPubMed

27.

Paran Y, Bendel P, Margalit R, Degani H. Water diffusion in the different microenvironments of breast cancer. NMR Biomed. 2004;17:170–80.CrossRefPubMed

28.

Jiang R, Ma Z, Dong H, Sun S, Zeng X, Li X. Diffusion tensor imaging of breast lesions: evaluation of apparent diffusion coefficient and fractional anisotropy and tissue cellularity. Br J Radiol. 2016;89(1064):20160076. doi:10.1259/bjr.20160076.CrossRefPubMedPubMedCentral

29.

Le Bihan D, Mangin JF, Poupon C, et al. Diffusion tensor imaging: concepts and applications. J Magn Reson Imaging. 2001;13:534–46.CrossRefPubMed

30.

Westin CF, Maier SE, Mamata H, Nabavi A, Jolesz FA, Kikinis R. Processing and visualization for diffusion tensor MRI. Med Image Anal. 2002;6:93–108.CrossRefPubMed

31.

Furman-Haran E, Grobgeld D, Nissan N, Shapiro-Feinberg M, Degani H. Can diffusion tensor anisotropy indices assist in breast cancer detection? J Magn Reson Imaging. 2016;44(6):1624–32. doi:10.1002/jmri.25292.CrossRefPubMed

32.

Eyal E, Shapiro-Feinberg M, Furman-Haran E, et al. Parametric diffusion tensor imaging of the breast. Investig Radiol. 2012;47:284–91.CrossRef

33.

Partridge SC, Ziadloo A, Murthy R, et al. Diffusion tensor MRI: preliminary anisotropy measures and mapping of breast tumors. J Magn Reson Imaging. 2010;31:339–47.CrossRefPubMed

34.

PAT B, Schäfer A, Dietzel M, et al. Diffusion tensor magnetic resonance imaging of the breast: a pilot study. Eur Radiol. 2011;21:1–10.CrossRef

35.

Cakir O, Arslan A, Inan N, et al. Comparison of the diagnostic performances of diffusion parameters in diffusion weighted imaging and diffusion tensor imaging of breast lesions. Eur J Radiol. 2013;82:e801–6.CrossRefPubMed

36.

Onaygil C, Kaya H, Ugurlu MU. Aribal E diagnostic performance of diffusion tensor imaging parameters in breast cancer and correlation with the prognostic factors. J Magn Reson Imaging. 2017;45(3):660–72. doi:10.1002/jmri.25481.CrossRefPubMed

37.

Nissan N, Furman-Haran E, Shapiro-Feinberg M, Grobgeld D, Degani H. Diffusion-tensor MR imaging of the breast: hormonal regulation. Radiology. 2014;271:672–80.CrossRefPubMed

38.

Just N. Improving tumour heterogeneity MRI. Br J Cancer. 2014;111:2205–13. doi:10.1038/bjc.2014.512.CrossRefPubMedPubMedCentral

39.

Geddes DT. Inside the lactating breast: the latest anatomy research. J Midwifery Womens Health. 2007;52:556–63.CrossRefPubMed

40.

Mortazavi SN, Hassiotou F, Geddes D, Hassanipour F. Mathematical modeling of mammary ducts in lactating human females. J Biomech Eng. 2015;137(7):071009 Paper No: BIO-14-1167. doi:10.1115/1.4028967.

41.

Panaritis V, Despotidis P, Kyriakidis A. Diameter of mammary terminal ducts as an additional tool in evaluation of women with polycystic ovarium disease. Arch Gynecol Obstet. 2004;270:252–4. doi:10.1007/s00404-003-0555-0.CrossRefPubMed

42.

Mayr NA, Staples JJ, Robinson RA, Vanmetre JE, Hussey DH. Morphometric studies in intraductal breast carcinoma using computerized image analysis. Cancer. 1991;67(11):2805–12.CrossRefPubMed

43.

Reisert M, Weigel M, Eyal E, Grobgeld D, Degani H, Hennig J. Diffusion tensor based reconstruction of the ductal tree. In: Proc Intl Soc Mag Reson Med. 2011;19:1011.

44.

Dewey KG, Finley DA, Lönnerdal B. Breast milk volume and composition during late lactation (7-20 months). J Pediatr Gastroenterol Nutr. 1984;3:713–20.CrossRefPubMed

45.

Shapiro-Feinberg M, Weisenberg N, Zehavi T, et al. Clinical results of DTI. Eur J Radiol. 2012;81:S151–2.CrossRefPubMed

46.

Middleton LP, Amin M, Gwyn K, Theriault R, Sahin A. Breast carcinoma in pregnant women: assessment of clinicopathologic and immunohistochemical features. Cancer. 2003;98(5):1055–60.CrossRefPubMed

47.

Kakoulidis I, Skagias L, Politi E. Pregnancy associated breast cancer (PABC): aspects in diagnosis. Breast Dis. 2015;35:157–66. ReviewCrossRefPubMed

48.

Nissan N, Furman-Haran E, Feinberg-Shapiro M, et al. Tracking the mammary architectural features and detecting breast cancer with magnetic resonance diffusion tensor imaging. J Vis Exp. 2014:e52048. doi:10.3791/52048.

Titel: Monitoring In-Vivo the Mammary Gland Microstructure during Morphogenesis from Lactation to Post-Weaning Using Diffusion Tensor MRI
verfasst von: Noam Nissan
Edna Furman-Haran
Myra Shapiro-Feinberg
Dov Grobgeld
Hadassa Degani
Publikationsdatum: 13.07.2017
Verlag: Springer US
Erschienen in: Journal of Mammary Gland Biology and Neoplasia / Ausgabe 3/2017
Print ISSN: 1083-3021
Elektronische ISSN: 1573-7039
DOI: https://doi.org/10.1007/s10911-017-9383-x

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Springer Medizin

Monitoring In-Vivo the Mammary Gland Microstructure during Morphogenesis from Lactation to Post-Weaning Using Diffusion Tensor MRI

Abstract

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Springer Medizin

Abstract

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Neu im Fachgebiet Onkologie

Adjuvante Immuntherapie verlängert Leben bei RCC

Alectinib verbessert krankheitsfreies Überleben bei ALK-positivem NSCLC

Bei Senioren mit Prostatakarzinom auf Anämie achten!

ICI-Therapie in der Schwangerschaft wird gut toleriert

Update Onkologie