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01.03.2009

The Association Between Major Birth Defects and Preterm Birth

verfasst von: Margaret A. Honein, Russell S. Kirby, Robert E. Meyer, Jian Xing, Nyasha I. Skerrette, Nataliya Yuskiv, Lisa Marengo, Joann R. Petrini, Michael J. Davidoff, Cara T. Mai, Charlotte M. Druschel, Samara Viner-Brown, Lowell E. Sever, for the National Birth Defects Prevention Network

Erschienen in: Maternal and Child Health Journal | Ausgabe 2/2009

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Abstract

Objective To evaluate the association between preterm birth and major birth defects by maternal and infant characteristics and specific types of birth defects. Study Design We pooled data for 1995–2000 from 13 states with population-based birth defects surveillance systems, representing about 30% of all U.S. births. Analyses were limited to singleton, live births from 24–44 weeks gestational age. Results Overall, birth defects were more than twice as common among preterm births (24–36 weeks) compared with term births (37–41 weeks gestation) (prevalence ratio [PR] = 2.65, 95% confidence interval [CI] 2.62–2.68), and approximately 8% of preterm births had a birth defect. Birth defects were over five times more likely among very preterm births (24–31 weeks gestation) compared with term births (PR = 5.25, 95% CI 5.15–5.35), with about 16% of very preterm births having a birth defect. Defects most strongly associated with very preterm birth included central nervous system defects (PR = 16.23, 95% CI 15.49–17.00) and cardiovascular defects (PR = 9.29, 95% CI 9.03–9.56). Conclusions Birth defects contribute to the occurrence of preterm birth. Research to identify shared causal pathways and risk factors could suggest appropriate interventions to reduce both preterm birth and birth defects.

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Titel: The Association Between Major Birth Defects and Preterm Birth
verfasst von: Margaret A. Honein
Russell S. Kirby
Robert E. Meyer
Jian Xing
Nyasha I. Skerrette
Nataliya Yuskiv
Lisa Marengo
Joann R. Petrini
Michael J. Davidoff
Cara T. Mai
Charlotte M. Druschel
Samara Viner-Brown
Lowell E. Sever
for the National Birth Defects Prevention Network
Publikationsdatum: 01.03.2009
Verlag: Springer US
Erschienen in: Maternal and Child Health Journal / Ausgabe 2/2009
Print ISSN: 1092-7875
Elektronische ISSN: 1573-6628
DOI: https://doi.org/10.1007/s10995-008-0348-y

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The Association Between Major Birth Defects and Preterm Birth

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Live-Webinar: Aktuelle Leitlinien bei Herz-Kreislauf-Erkrankungen

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