Abstract
Lignan complex has been isolated from flaxseed. It has been shown to reduce serum lipids and the extent of hypercholesterolemic atherosclerosis. However, it is not known whether the chronic use of lignan complex has any adverse effects on the hemopoietic system. The effects of lignan complex (40 mg/kg body wt orally daily for 2 months) on the red blood cells (RBC) count, mean corpuscular volume (MCV), red cell distribution width (RDW), hematocrit (Hct), hemoglobin (Hb), mean corpuscular hemoglobin (MCH), mean corpuscular hemoglobin concentration (MCHC), and counts of white blood cell (WBC), granulocytes, lymphocytes, monocytes and platelet, and platelet volume were investigated in normo- and hypercholesterolemic rabbits. The results show that lignan complex had no adverse effects of counts of RBC, WBC, granulocytes, lymphocytes, monocytes and platelet in both the normo- and hyper-cholesterolemic rabbits. The values for MCV, RDW, Hct, Hb, MCH, MCHC, and platelet volume were similar in lignan complex-treated or untreated normo- and hypercholesterolemic rabbits. It is concluded that chronic use of lignan complex had no adverse effects on the hemopoietic system. (Mol Cell Biochem 270: 139–145, 2005)
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Hettiarachchy, NS, Hareland GA, Ostenson A et al.: Chemical composition of 11 flaxseed varieties grown in North Dakota. Proc Flax Inst 53: 36, 1990
Oomah BD, Mazza G: Flaxseed proteins: A review. Food Chem 48: 109–114, 1993
Prasad K, Mantha SV, Muir AD, Westcott ND: Reduction of hypocholesterolemic atherosclerosis by CDC-flaxseed with very low alpha-linolenic acid. Atherosclerosis 136: 367–375, 1998
Westcott ND, Paton D: A complex containing lignan, phenolic and aliphatic substances from flax and process for preparing. U.S. Patent #6264853, July 24/2001
Prasad K: Hydroxyl radical-scavenging property of secoisolariciresinol diglucoside (SDG) isolated from flaxseed. Mol Cell Biochem 168: 117–123, 1997
Prasad K: Antioxidant activity of secoisolariciresinol diglucoside-derived metabolites, secoisolariciresinol, enterodiol, and enterolactone. Int J Angiol 9: 220–225, 2000
Foti M, Piatelli M, Baratta MT: Flavonoids, Coumarism, and cinnamic acids as antioxidants in micellar system. Structure activity relationship. J Agri Food Chem 44: 497–501, 1996
Miller NJ: Flavonoids and phenyl-propanoids as contributors to the antioxidant activity of fruit juices. In: C.A. Rice-Evans and L. Packer (eds). Flavonoids in Health and Disease, Marcel Decker, New York, 1998, pp 387–403, 1998
Lupien PJ, Moorjani S, Brun D, Bielmann I: Effects of 3-hydroxy-3-methylglutaric acid on plasma and low-density lipoprotein cholesterol levels in familial hypercholesterolemia. J Clin Pharmacol 19: 120–126, 1979
Prasad K: Reduction of serum cholesterol and hypercholesterolemic atherosclerosis in rabbits by secoisolariciresinol diglucoside isolated from flaxseed. Circulation 99: 1355–1362, 1999
Prasad K: Dietary flaxseed in prevention of hypercholesterolemic atherosclerosis. Atherosclerosis 132: 69–76, 1997
Prasad K, Mantha SV, Muir AD, Westcott N: Protective effect of secoisolariciresinol diglucoside against streptozotocin-induced diabetes and its mechanism. Mol Cell Biochem 206: 141–150, 2000
Prasad K: Oxidative stress as a mechanism of diabetes in diabetic prone rats: Effect of secoisolariciresinol diglucoside (SDG). Mol Cell Biochem 209: 89–96, 2000
Prasad K: Secoisolariciresinol diglucoside from flaxseed delays the development of type-2 diabetes in Zucker rat. J Lab Clin Med 138: 32–39, 2001
Banyai S, Banyai M, Falger J, Jansen M, Alt E, Derfler K, Koppensteiner R: Atorvastatin improves blood rheology in patients with familial hypercholesterolemia (FH) on long-term LDL apheresis treatment. Atherosclerosis 159: 513–519, 2001
Choi JW, Pai SH: Influences of hypercholesterolemia on red cell indices and erythrocyte sedimentation rate in elderly persons. Clin Chim Acta 341: 117–121, 2004
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Prasad, K. Effect of chronic administration of lignan complex isolated from flaxseed on the hemopoietic system. Mol Cell Biochem 270, 139–145 (2005). https://doi.org/10.1007/s11010-005-5283-2
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DOI: https://doi.org/10.1007/s11010-005-5283-2