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01.09.2010 | Original Paper

Protein and lipid oxidative damage in streptozotocin-induced diabetic rats submitted to forced swimming test: the insulin and clonazepam effect

verfasst von: Carlos Alberto Yasin Wayhs, Vanusa Manfredini, Angela Sitta, Marion Deon, Graziela Ribas, Camila Vanzin, Giovana Biancini, Marcelo Ferri, Maurício Nin, Helena Maria Tannhauser Barros, Carmen Regla Vargas

Erschienen in: Metabolic Brain Disease | Ausgabe 3/2010

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Abstract

Diabetes may modify central nervous system functions and is associated with moderate cognitive deficits and changes in the brain, a condition that may be referred to as diabetic encephalopathy. The prevalence of depression in diabetic patients is higher than in the general population, and clonazepam is being used to treat this complication. Oxidative stress may play a role in the development of diabetes complications. We investigated oxidative stress parameters in streptozotocin-induced diabetic rats submitted to forced swimming test (STZ) and evaluated the effect of insulin (STZ-INS) and/or clonazepam (STZ-CNZ and STZ-INS-CNZ) acute treatment on these animal model. Oxidative damage to proteins measured as carbonyl content in plasma was significantly increased in STZ group compared to STZ treated groups. Malondialdehyde plasma levels were significantly reduced in STZ-INS and STZ-INS-CNZ groups when compared to STZ rats, being significantly reduced in STZ-INS-CNZ than STZ-INS rats. The activities of the antioxidant enzymes catalase, superoxide dismutase and glutathione peroxidase showed no significant differences among all groups of animals. These findings showed that protein and lipid damage occurs in this diabetes/depression animal model and that the associated treatment of insulin and clonazepam is capable to protect against oxidative damage in this experimental model.

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Titel: Protein and lipid oxidative damage in streptozotocin-induced diabetic rats submitted to forced swimming test: the insulin and clonazepam effect
verfasst von: Carlos Alberto Yasin Wayhs
Vanusa Manfredini
Angela Sitta
Marion Deon
Graziela Ribas
Camila Vanzin
Giovana Biancini
Marcelo Ferri
Maurício Nin
Helena Maria Tannhauser Barros
Carmen Regla Vargas
Publikationsdatum: 01.09.2010
Verlag: Springer US
Erschienen in: Metabolic Brain Disease / Ausgabe 3/2010
Print ISSN: 0885-7490
Elektronische ISSN: 1573-7365
DOI: https://doi.org/10.1007/s11011-010-9211-0

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Protein and lipid oxidative damage in streptozotocin-induced diabetic rats submitted to forced swimming test: the insulin and clonazepam effect

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