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Metabolic Brain Disease

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01.02.2016 | Original Article

Frontal white matter changes and aggression in methamphetamine dependence

verfasst von: Katharina Lederer, Jean-Paul Fouche, Don Wilson, Dan J. Stein, Anne Uhlmann

Erschienen in: Metabolic Brain Disease | Ausgabe 1/2016

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Abstract

Chronic methamphetamine (MA) use can lead to white matter (WM) changes and increased levels of aggression. While previous studies have examined WM abnormalities relating to cognitive impairment, associations between WM integrity and aggression in MA dependence remain unclear. Diffusion Tensor Imaging (DTI) was used to investigate WM changes in 40 individuals with MA dependence and 40 matched healthy controls. A region of interest (ROI) approach using tract based spatial statistics (TBSS) in FSL was performed. We compared fractional anisotropy (FA), mean diffusivity (MD), parallel diffusivity (λ_║) and perpendicular diffusivity (λ_┴) in WM tracts of the frontal brain. A relationship of WM with aggression scores from the Buss & Perry Questionnaire was investigated. Mean scores for anger (p < 0.001), physical aggression (p = 0.032) and total aggression (p = 0.021) were significantly higher in the MA group relative to controls. ROI analysis showed increased MD (U = 439.5, p = 0.001) and λ_┴ (U = 561.5, p = 0.021) values in the genu of the corpus callosum, and increased MD (U = 541.5, p = 0.012) values in the right cingulum in MA dependence. None of the WM changes were significantly associated with aggression scores. This study provides evidence of frontal WM changes and increased levels of aggression in individuals with MA dependence. The lack of significant associations between WM and aggressive behaviour may reflect methodological issues in measuring such behaviour, or may indicate that the neurobiology of aggression is not simply correlated with WM damage but is more complex.

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Titel: Frontal white matter changes and aggression in methamphetamine dependence
verfasst von: Katharina Lederer
Jean-Paul Fouche
Don Wilson
Dan J. Stein
Anne Uhlmann
Publikationsdatum: 01.02.2016
Verlag: Springer US
Erschienen in: Metabolic Brain Disease / Ausgabe 1/2016
Print ISSN: 0885-7490
Elektronische ISSN: 1573-7365
DOI: https://doi.org/10.1007/s11011-015-9775-9

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Frontal white matter changes and aggression in methamphetamine dependence

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