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Erschienen in: Metabolic Brain Disease 3/2018

30.12.2017 | Original Article

The effects of vitamin E on brain derived neurotrophic factor, tissues oxidative damage and learning and memory of juvenile hypothyroid rats

verfasst von: Yousef Baghcheghi, Farimah Beheshti, Mohammad Naser Shafei, Hossein Salmani, Hamid Reza Sadeghnia, Mohammad Soukhtanloo, Akbar Anaeigoudari, Mahmoud Hosseini

Erschienen in: Metabolic Brain Disease | Ausgabe 3/2018

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Abstract

The effects of vitamin E (Vit E) on brain derived neurotrophic factor (BDNF) and brain tissues oxidative damage as well as on learning and memory impairments in juvenile hypothyroid rats were examined. The rats were grouped as: (1) Control; (2) Propylthiouracil (PTU); (3) PTU-Vit E and (4) Vit E. PTU was added to their drinking water (0.05%) during 6 weeks. Vit E (20 mg/kg) was daily injected (IP). Morris water maze (MWM) and passive avoidance (PA) were carried out. The animals were deeply anesthetized and the brain tissues were removed for biochemical measurements. PTU increased the escape latency and traveled path in MWM (P < 0.001). It also shortened the latency to enter the dark compartment of PA as well as the time spent in the target quadrant in probe trial of MWM (P < 0.01-P < 0.001). All the effects of PTU were reversed by Vit E (P < 0.01-P < 0.001). PTU administration attenuated thiol and BDNF content as well as the activities of superoxide dismutase (SOD) and catalase (CAT) in the brain tissues while increased molondialdehyde (MDA). Moreover, Vit E improved BDNF, thiol, SOD and CAT while diminished MDA. The results of the present study showed that Vit E improved BDNF and prevented from brain tissues oxidative damage as well as learning and memory impairments in juvenile hypothyroid rats.
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Metadaten
Titel
The effects of vitamin E on brain derived neurotrophic factor, tissues oxidative damage and learning and memory of juvenile hypothyroid rats
verfasst von
Yousef Baghcheghi
Farimah Beheshti
Mohammad Naser Shafei
Hossein Salmani
Hamid Reza Sadeghnia
Mohammad Soukhtanloo
Akbar Anaeigoudari
Mahmoud Hosseini
Publikationsdatum
30.12.2017
Verlag
Springer US
Erschienen in
Metabolic Brain Disease / Ausgabe 3/2018
Print ISSN: 0885-7490
Elektronische ISSN: 1573-7365
DOI
https://doi.org/10.1007/s11011-017-0176-0

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