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Erythropoietin augments the efficacy of therapeutic angiogenesis induced by allogenic bone marrow stromal cells in a rat model of limb ischemia

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Abstract

Transplantation of adult marrow stromal cells (MSCs) has been developed as a new method of treating severe ischemia diseases by therapeutic angiogenesis. Erythropoietin (EPO) is capable of inducing angiogenesis and inhibiting MSCs apoptosis. The effect of EPO on the therapeutic potency of MSCs transplantation in a rat model of limb ischemia was investigated in the current study. The results indicate that the combined treatment with MSC transplantation and EPO infusion is superior to MSC transplantation alone in the treatment of limb ischemia. MSCs transplantation and EPO infusion could enhance the angiogenic effect of each other to achieve a better therapeutic effect. This combination therapy may become a more effective approach for ischemia diseases of the limbs.

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Acknowledgments

This study was supported in part by grants from scientific research foundation of special purpose for doctors in higher education, this study was also supported in part by Shandong province young scientists research rewarding foundation, we thank Shandong province hospital for allowing us using their laboratories. We are grateful to Weidong Zhang, Qing Jia, Wei Xin, and Xiaoxia Lv for their technical assistance.

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Authors and Affiliations

  1. Department of Vascular Surgery, Shandong Provincial Hospital, Shandong University, 250021, Jinan, People’s Republic of China

    Xiangqian Hou, Xuejun Wu, Junxi Ma, Xinhui Lv & Xing Jin

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  1. Xiangqian Hou
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Correspondence to Xing Jin.

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Hou, X., Wu, X., Ma, J. et al. Erythropoietin augments the efficacy of therapeutic angiogenesis induced by allogenic bone marrow stromal cells in a rat model of limb ischemia. Mol Biol Rep 37, 1467–1475 (2010). https://doi.org/10.1007/s11033-009-9541-3

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  • DOI: https://doi.org/10.1007/s11033-009-9541-3

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