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CDH1 promoter polymorphism and stomach cancer susceptibility

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Abstract

The relationship of stomach cancer susceptibility and the presence of E-cadherin (CDH1) promoter −160 C/A polymorphism had been reported with conflicting results. To further explore the association of this polymorphism with stomach cancer susceptibility, we performed an extensive search of relevant studies and carried out a meta-analysis to obtain a more precise estimate. A total of 16 studies including 2,611 cases and 3,788 controls were involved in this meta-analysis. When all studies involved, the meta-analysis results suggest no statistically significant association between CDH1 −160 C/A polymorphism and stomach cancer risk (CA vs. CC: OR = 1.01, 95% CI: 0.85–1.19; AA vs. CC: OR = 1.05, 95% CI: 0.75–1.46; dominant model: OR = 1.02, 95% CI: 0.86–1.20; recessive model: OR = 1.04, 95% CI: 0.76–1.41). When subgroup analyses were performed by ethnicity, the A-allele carriers conferred a decreased stomach cancer risk in Asians (AA vs. CC: OR = 0.67, 95% CI: 0.47–0.96; dominant model: OR = 0.85, 95% CI: 0.72–0.99), but no statistically significant association was found in Caucasians. In conclusion, this meta-analysis suggests that CDH1 −160 A-allele may play a protective role of stomach cancer development in Asians but not in Caucasians.

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References

  1. Parkin DM, Bray F, Ferlay J, Pisani P (2005) Global cancer statistics, 2002. CA Cancer J Clin 55:74–108

    Article  PubMed  Google Scholar 

  2. Pecina-Slaus N (2003) Tumor suppressor gene E-cadherin and its role in normal and malignant cells. Cancer Cell Int 3:17–23

    Article  PubMed  Google Scholar 

  3. Takeichi M (1991) Cadherin cell adhesion receptors as a morphogenetic regulator. Science 22:1451–1455

    Article  Google Scholar 

  4. Berx G, Becker K, Hofler H, Roy F (1998) Mutations in the human E-cadherin (CDH1) gene. Hum Mutat 12:226–237

    Article  PubMed  CAS  Google Scholar 

  5. Nakamura A, Shimazaki T, Kaneko K (2002) Characterization of DNA polymorphisms in the E-cadherin gene (CDH1) promoter region. Mutat Res 502:19–24

    Article  PubMed  CAS  Google Scholar 

  6. Li LC, Chui RM, Sasaki M (2000) A single nucleotide polymorphism in the E-cadherin gene promoter alters transcriptional activities. Cancer Res 60:873–879

    PubMed  CAS  Google Scholar 

  7. Qiu LX, Li RT, Zhang JB, Zhong WZ, Bai JL, Liu BR (2009) The E-cadherin (CDH1)—160 C/A polymorphism and prostate cancer risk: a meta-analysis. Eur J Hum Genet 17:244–249

    Article  PubMed  CAS  Google Scholar 

  8. Zhang XF, Wang YM, Ge H (2008) Association of CDH1 single nucleotide polymorphisms with susceptibility to esophageal squamous cell carcinomas and gastric cardia carcinomas. Dis Esophagus 21:21–29

    Article  PubMed  Google Scholar 

  9. Shin Y, Kim IJ, Kang HC, Park JH, Park HR, Park HW (2004) The E-cadherin −347G→GA promoter polymorphism and its effect on transcriptional regulation. Carcinogenesis 25:895–899

    Article  PubMed  Google Scholar 

  10. Wu MS, Huang SP, Chang YT (2002) Association of the −160 C/A promoter polymorphism of E-cadherin gene with gastric carcinoma risk. Cancer 94:1443–1448

    Article  PubMed  CAS  Google Scholar 

  11. Kuraoka K, Oue N, Yokozaki H (2003) Correlation of a single nucleotide polymorphism in the E-cadherin gene promoter with tumorigenesis and progression of gastric carcinoma in Japan. Int J Oncol 23:421–427

    PubMed  CAS  Google Scholar 

  12. Park WS, Cho YG, Park JY (2003) A single nucleotide polymorphism in the E-cadherin gene promoter-160 is not associated with risk of Korean gastric cancer. J Korean Med Sci 18:501–504

    PubMed  CAS  Google Scholar 

  13. Song CG, Huang CM, Liu X, Lu HS, Zhang XF, Huang W (2005) Association of −160(C>A) polymorphism in CDH1 gene with gastric cancer risk in Fujian Chinese population. Zhonghua Yi Xue Yi Chuan Xue Za Zhi 22:557–559

    PubMed  CAS  Google Scholar 

  14. Lu Y, Xu YC, Shen J (2005) E-cadherin gene C-160A promoter polymorphism and risk of non-cardia gastric cancer in a Chinese population. World J Gastroenterol 11:56–60

    PubMed  Google Scholar 

  15. Yamada H, Shinmura K, Ikeda S (2007) Association between CDH1 haplotypes and gastric cancer risk in a Japanese population. Scand J Gastroenterol 42:1479–1485

    Article  PubMed  CAS  Google Scholar 

  16. Humar B, Graziano F, Cascinu S (2002) Association of CDH1 haplotypes with susceptibility to sporadic diffuse gastric cancer. Oncogene 21:8192–8195

    Article  PubMed  CAS  Google Scholar 

  17. Pharoah PD, Oliveira C, Machado JC (2002) CDH1 c-160a promoter polymorphism is not associated with risk of stomach cancer. Int J Cancer 101:196–197

    Article  PubMed  CAS  Google Scholar 

  18. Jenab M, McKay JD, Ferrari P (2008) CDH1 gene polymorphisms, smoking, Helicobacter pylori infection and the risk of gastric cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC-EURGAST). Eur J Cancer 44:774–780

    Article  PubMed  CAS  Google Scholar 

  19. Cattaneo F, Venesio T, Molatore S, Russo A, Fiocca R, Frattini M (2006) Functional analysis and case-control study of −160C/A polymorphism in the E-cadherin gene promoter: association with cancer risk. Anticancer Res 26:4627–4632

    PubMed  CAS  Google Scholar 

  20. Corso G, Berardi A, Marrelli D, Pedrazzani C, Garosi L, Pinto E (2009) CDH1 C-160A promoter polymorphism and gastric cancer risk. Eur J Cancer Prev 18:46–49

    Article  PubMed  CAS  Google Scholar 

  21. Medina-Franco H, Ramos-De la Medina A, Vizcaino G, Medina-Franco JL (2007) Single nucleotide polymorphisms in the promoter region of the E-cadherin gene in gastric cancer: case-control study in a young Mexican population. Ann Surg Oncol 14:2246–2249

    Article  PubMed  Google Scholar 

  22. Cochran WG (1954) The combination of estimates from different experiments. Biometrics 10:101–129

    Article  Google Scholar 

  23. Mantel N, Haenszel W (1959) Statistical aspects of the analysis of data from retrospective studies of disease. J Natl Cancer Inst 22:719–748

    PubMed  CAS  Google Scholar 

  24. DerSimonian R, Laird N (1986) Meta-analysis in clinical trials. Control Clin Trials 7:177–188

    Article  PubMed  CAS  Google Scholar 

  25. Egger M, Davey Smith G, Schneider M, Minder C (1997) Bias in metaanalysis detected by a simple, graphical test. BMJ 315:629–634

    Article  PubMed  CAS  Google Scholar 

  26. Li C, Jiang Z, Liu X (2010) XPD Lys 751 Gln and Asp 312 Asn polymorphisms and bladder cancer risk: a meta-analysis. Mol Biol Rep 37:301–309

    Article  PubMed  CAS  Google Scholar 

  27. Zhu Y, Wang J, He Q, Zhang JQ (2010) Association of p53 codon 72 polymorphism with prostate cancer: a meta-analysis. Mol Biol Rep. doi:10.1007/s11033-010-0269-x

  28. Qiu LX, Zhang J, Li WH, Zhang QL, Yu H, Wang BY (2010) Lack of association between methylenetetrahydrofolate reductase gene A1298C polymorphism and breast cancer susceptibility. Mol Biol Rep. doi:10.1007/s11033-010-0361-2

  29. Liao RY, Mao C, Qiu LX, Ding H, Chen Q, Pan HF (2010) TGFBR1*6A/9A polymorphism and cancer risk: a meta-analysis of 13,662 cases and 14,147 controls. Mol Biol Rep 37:3227–3232

    Article  PubMed  CAS  Google Scholar 

  30. Qiu LX, Wang K, Yang S, Mao C, Zhao L, Yao L (2010) Current evidences on vascular endothelial growth factor polymorphisms and breast cancer susceptibility. Mol Biol Rep. doi:10.1007/s11033-010-0579-z

  31. Tsukino H, Kuroda Y, Nakao H (2003) E-cadherin gene polymorphism and risk of urothelial cancer. Cancer Lett 195:53–59

    Article  PubMed  CAS  Google Scholar 

  32. Hirschhorn JN, Lohmueller K, Byrne E (2002) A comprehensive review of genetic association studies. Genet Med 4:45–61

    Article  PubMed  CAS  Google Scholar 

  33. Wacholder S, Chanock S, Garcia-Closas M (2004) Assessing the probability that a positive report is false: an approach for molecular epidemiology studies. J Natl Cancer Inst 96:434–442

    Article  PubMed  Google Scholar 

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Authors and Affiliations

  1. Department of Gastroenterology, The First Affiliated Hospital of China Medical University, Shenyang, China

    Yi-Ling Li & Bao-Yu Fu

  2. Department of General Surgery, Shengjing Hospital of China Medical University, Shenyang, China

    Zhong Tian

  3. Cancer Research Institute, Nantong University, Nantong, China

    Jian-Bing Zhang

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  1. Yi-Ling Li
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  2. Zhong Tian
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Correspondence to Yi-Ling Li.

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Li, YL., Tian, Z., Zhang, JB. et al. CDH1 promoter polymorphism and stomach cancer susceptibility. Mol Biol Rep 39, 1283–1286 (2012). https://doi.org/10.1007/s11033-011-0860-9

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  • DOI: https://doi.org/10.1007/s11033-011-0860-9

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