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Association between XRCC1 and XRCC3 polymorphisms and colorectal cancer risk: a meta-analysis of 23 case–control studies

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Abstract

Several potential functional polymorphisms in the DNA repair gene X-ray repair cross-complementing group 1 (XRCC1) Arg399Gln (rs25487), Arg194Trp (rs1799782), Arg280His (rs25489) and X-ray repair cross-complementing group 3 (XRCC3) T241M (rs861539) have been implicated in colorectal cancer (CRC) risk, but the results are conflicting. Here, we performed a meta-analysis of 23 published case control datasets and assessed genetic heterogeneity between those datasets. All the case–control studies published from January 2000 to June 2012 on the association between those polymorphisms and CRC risk were identified by searching the electronic literature Medline. Statistical analysis was performed with the software programs Review Manager (version 4.2). For overall CRC, no significant association was observed, the pooled odds ratios for XRCC1 Arg399Gln, Arg194Trp, Arg280His, and XRCC3 T241M were 1.02 (95 % CI: 0.93, 1.12), 1.03 (95 % CI: 0.94, 1.14), 0.98 (95 % CI: 0.85, 1.13) and 1.03 (95 % CI: 0.85, 1.26), respectively. Furthermore, no significant association was observed in subgroup analyses based on ethnicity. The results suggested that these four SNPs evaluated are not associated with risk of CRC.

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Acknowledgments

We thank all those who participated in the studies. We also thank Dr. Zhibin Hu and Dr. Congyi Wang for their excellent technical assistance. This study was supported in part by the National Natural Scientific Foundation of China grants 81172266.

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No competing financial interests exist.

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Authors and Affiliations

  1. Institute of Digestive Endoscopy and Medical Center for Digestive Diseases, Second Affiliated Hospital of Nanjing Medical University, 121 Jiang Jia Yuan, Nanjing, 210011, China

    Li Liu, Lin Miao, Guozhong Ji, Zheng Liu & Zhining Fan

  2. Tumor Hospital of Nantong City, Nantong, 226000, China

    Li Liu & Fulin Qiang

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  1. Li Liu
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  2. Lin Miao
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  3. Guozhong Ji
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  4. Fulin Qiang
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  5. Zheng Liu
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  6. Zhining Fan
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Correspondence to Zhining Fan.

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Li Liu and Lin Miao contributed equally to this study.

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Liu, L., Miao, L., Ji, G. et al. Association between XRCC1 and XRCC3 polymorphisms and colorectal cancer risk: a meta-analysis of 23 case–control studies. Mol Biol Rep 40, 3943–3952 (2013). https://doi.org/10.1007/s11033-012-2471-5

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  • DOI: https://doi.org/10.1007/s11033-012-2471-5

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