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Erschienen in: Journal of Neuro-Oncology 2/2009

01.04.2009 | Clinical study - patient study

A multimodal strategy based on surgery, radiotherapy, ICE regimen and high dose chemotherapy in atypical teratoid/rhabdoid tumours: a single institution experience

verfasst von: Paola Fidani, Maria Antonietta De Ioris, Annalisa Serra, Luigi De Sio, Ilaria Ilari, Raffaele Cozza, Renata Boldrini, Giuseppe Maria Milano, Maria Luisa Garrè, Alberto Donfrancesco

Erschienen in: Journal of Neuro-Oncology | Ausgabe 2/2009

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Abstract

Purpose Atypical Teratoid/Rhabdoid Tumour is a rare and aggressive childhood tumour. The outcome of a series treated with the same multimodal strategy was reported. Patients The patients were treated with surgery, 2 courses of ifosfamide/carboplatin/etoposide(ICE), 2 courses of cyclophosphamide/etoposide/carboplatino/thiotepa (CECAT) or 2 other ICE courses, high dose chemotherapy (HDC) and radiotherapy. Results Eight patients underwent primary surgery achieving a complete removal in 3. Progressive disease (PD) occurred in 2/8 patients during ICE courses and in 3/4 during CECAT courses. After 4 courses 5 patients presented a PD. HDC was performed in 3 patients followed by local radiotherapy. The Kaplan Meier OS and EFS probability at 5 years are, respectively, 50% (CI 11–80%) and 33% (CI 6–66%). Conclusion A strategy based on surgery, including a second surgical look, and on radiotherapy appears the best option. ICE regimen and HDC correlate with good prognosis in some patients but this approach needs further evaluation.
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Metadaten
Titel
A multimodal strategy based on surgery, radiotherapy, ICE regimen and high dose chemotherapy in atypical teratoid/rhabdoid tumours: a single institution experience
verfasst von
Paola Fidani
Maria Antonietta De Ioris
Annalisa Serra
Luigi De Sio
Ilaria Ilari
Raffaele Cozza
Renata Boldrini
Giuseppe Maria Milano
Maria Luisa Garrè
Alberto Donfrancesco
Publikationsdatum
01.04.2009
Verlag
Springer US
Erschienen in
Journal of Neuro-Oncology / Ausgabe 2/2009
Print ISSN: 0167-594X
Elektronische ISSN: 1573-7373
DOI
https://doi.org/10.1007/s11060-008-9750-y

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