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01.05.2010 | Clinical Study - Patient Study

Primary CNS lymphoma in the elderly: temozolomide therapy and MGMT status

verfasst von: Delia Kurzwelly, Martin Glas, Patrick Roth, Elke Weimann, Hanns Lohner, Andreas Waha, Martin Schabet, Guido Reifenberger, Michael Weller, Ulrich Herrlinger

Erschienen in: Journal of Neuro-Oncology | Ausgabe 3/2010

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Abstract

This retrospective series explores temozolomide monotherapy in elderly patients with primary CNS lymphoma (PCNSL) and severe comorbidities. In 17 patients (62–90 years old), the complete response rate was 47%, median progression-free survival was 5 months, and median overall survival was 21 months. Five of 17 patients (29.4%) had prolonged responses for at least 12 months and survived for more than 24 months. Three of these patients had a methylated O⁶-methylguanine-DNA methyltransferase (MGMT) promoter, while the MGMT status was not assessable in the remaining two patients. Temozolomide monotherapy appears to be effective in a subgroup of elderly PCNSL patients and deserves further evaluation.

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Titel: Primary CNS lymphoma in the elderly: temozolomide therapy and MGMT status
verfasst von: Delia Kurzwelly
Martin Glas
Patrick Roth
Elke Weimann
Hanns Lohner
Andreas Waha
Martin Schabet
Guido Reifenberger
Michael Weller
Ulrich Herrlinger
Publikationsdatum: 01.05.2010
Verlag: Springer US
Erschienen in: Journal of Neuro-Oncology / Ausgabe 3/2010
Print ISSN: 0167-594X
Elektronische ISSN: 1573-7373
DOI: https://doi.org/10.1007/s11060-009-0032-0

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Primary CNS lymphoma in the elderly: temozolomide therapy and MGMT status

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