Introduction
Patients and methods
Patients
Pat. no. | Age [years] | Gender (F = female M = male) | Diagnosis | WHO grade | Localization | Newly diagnosed (ND)/recurrence (REC) | Sxa
| Rxb
| Cxc
|
---|---|---|---|---|---|---|---|---|---|
1 | 17 | F | Pilocytic astrocytoma | I | Right fronto- parietal | ND | No | No | No |
2 | 13 | M | Pilocytic astrocytoma | I | 3rd ventricle | REC | Yes | No | No |
3 | 16 | F | Pilocytic astrocytoma | I | Left thalamus | REC | No | Yes | No |
4 | 11 | F | Pilocytic astrocytoma | I | Right basal ganglia | ND | No | No | No |
5 | 19 | M | Pilocytic astrocytoma | I | Sellar region | REC | No | Yes | No |
6 | 12 | M | Pilocytic astrocytoma | I | Right basal ganglia | REC | No | Yes | No |
7 | 14 | F | DNT | I | Left temporal | ND | No | No | No |
8 | 17 | M | DIG | I | Left temporal | ND | No | No | No |
9 | 10 | M | Astrocytoma | II | Right parietal | ND | No | No | No |
10 | 8 | M | Astrocytoma | II | Left temporal | ND | No | No | No |
11 | 21 | F | Astrocytoma | II | Left temporal | ND/RECd
| No | No | No |
12 | 21 | F | Astrocytoma | II | Left precentral | ND/RECd
| No | Yes | No |
13 | 20 | M | Astrocytoma | II | Left frontal | REC | Yes | Yes | Yes |
14 | 4 | F | Astrocytoma | II | Quadrigeminal plate | ND | No | No | No |
15 | 10 | M | Pleomorphic xanthoastrocytoma | II | Left temporal | ND/RECd
| Yes | No | No |
16 | 13 | M | Ependymoma | II | Left cerebellum | REC | No | Yes | No |
17 | 20 | F | Astrocytoma | III | Right thalamus | REC | No | Yes | No |
18 | 21 | F | Astrocytoma | III | Right basal ganglia | REC | No | Yes | No |
19 | 14 | M | Astrocytoma | III | Left pericentral | REC | Yes | Yes | No |
20 | 14 | F | Astrocytoma | III | Right frontal | REC | Yes | Yes | No |
21 | 19 | F | Oligoastrocytoma | III | Left temporo-parietal | ND/RECd
| Yes | Yes | Yes |
22 | 21 | F | Oligoastrocytoma | III | Right internal capsula | REC | Yes | Yes | No |
23 | 18 | M | Glioblastoma | IV | Left temporal | REC | Yes | Yes | Yes |
24 | 12 | F | Glioblastoma | IV | Right thalamus | REC | Yes | Yes | Yes |
25 | 20 | F | Medulloblastoma | IV | Left cerebellum | REC | Yes | Yes | Yes |
26 | 10 | F | Medulloblastoma | IV | Right frontal | REC | Yes | Yes | No |
27 | 21 | M | Medulloblastoma | IV | Pons | REC | Yes | Yes | Yes |
28 | 8 | F | Medulloblastoma | IV | Right cerebellum | REC | Yes | No | Yes |
29 | 11 | F | Ependymoblastoma | IV | Right fronto-temporal | REC | Yes | Yes | No |
30 | 2 | F | ATRT | IV | Brainstem | REC | Yes | No | Yes |
31 | 9 | M | ATRT | IV | Right temporo-occipital | REC | Yes | No | No |
32 | 19 | M | Cortical malformation | / | Right temporal | ND | No | No | No |
33 | 19 | F | Cortical malformation | / | Left temporal | ND | No | No | No |
34 | 21 | M | Epilepsy | / | Right fronto-parietal | ND | No | No | No |
35 | 18 | F | Pineal cyst | / | Pineal gland | ND | No | No | No |
36 | 19 | F | ADEM | / | Right occipital | ND | No | No | No |
37 | 18 | F | Multiple sclerosis | / | Left parieto-occipital | ND | No | No | No |
38 | 20 | F | Multiple sclerosis | / | Left occipital | ND | No | No | No |
39 | 18 | M | Stroke PCA | / | Left occipital | ND | No | No | No |
Histological diagnosis and WHO grade | Total | Under age of 15 | 15–21 years |
---|---|---|---|
Histological diagnoses | |||
Pilocytic astrocytoma I | 6 | 3 | 3 |
Astrocytoma II | 6 | 3 | 3 |
Pleomorphic xanthoastrocytoma II | 1 | 1 | 0 |
Astrocytoma III | 4 | 2 | 2 |
Oligoastrocytoma III | 2 | 0 | 2 |
Glioblastoma IV | 2 | 1 | 1 |
Medulloblastoma IV | 4 | 2 | 2 |
Atypical teratoid rhabdoid tumor IV | 2 | 2 | 0 |
Ependymoma II | 1 | 1 | 0 |
Ependymoblastoma IV | 1 | 1 | 0 |
DNT I | 1 | 1 | 0 |
Desmoplastic infantile ganglioglioma I | 1 | 0 | 1 |
Non-tumor lesions | 8 | 0 | 8 |
Total | 39 | 17 | 22 |
# | Pat. no. | Age [years] | Gender (F = female M = male) | Diagnosis | WHO grade | Localization | Number of MET-PET scans [n] | Diagnosis confirmed by |
---|---|---|---|---|---|---|---|---|
1 | 1 | 17 | F | Pilocytic astrocytoma | I | Right fronto-parietal | 1 | 1 |
2 | 4 | 11 | F | Pilocytic astrocytoma | I | Right basal ganglia | 1 | 1 |
3 | 7 | 14 | F | DNT | I | Left temporal | 1 | 1 |
4 | 8 | 17 | M | DIG | I | Left temporal | 1 | 1 |
5 | 9 | 10 | M | Astrocytoma | II | Right parietal | 1 | 1 |
6 | 10 | 8 | M | Astrocytoma | II | Left temporal | 1 | 1 |
7 | 14 | 4 | F | Astrocytoma | II | Quadrigeminal plate | 1 | 1 |
8 | 32 | 19 | M | Cortical malformation | / | Right temporal | 1 | 2 |
9 | 33 | 19 | F | Cortical malformation | / | Left temporal | 1 | 2 |
10 | 34 | 21 | M | Epilepsy | / | Right fronto-parietal | 1 | 3 |
11 | 35 | 18 | F | Pineal cyst | / | Pineal gland | 1 | 2 |
12 | 36 | 19 | F | ADEM | / | Right occipital | 2 | 1 |
13 | 37 | 18 | F | Multiple sclerosis | / | Left parieto-occipital | 1 | 3 |
14 | 38 | 20 | F | Multiple sclerosis | / | Left occipital | 1 | 2 |
15 | 39 | 18 | M | Stroke PCA | / | Left occipital | 1 | 3 |
# | Pat. no. | Age [years] | Gender (F = female M = male) | Diagnosis | WHO grade | Localization | Number of MET-PET scans [n] | Diagnosis confirmed by |
---|---|---|---|---|---|---|---|---|
1 | 2 | 13 | M | Pilocytic astrocytoma | I | 3rd ventricle | 1 | 3 |
2 | 3 | 16 | F | Pilocytic astrocytoma | I | Left thalamus | 1 | 3 |
3 | 5 | 19 | M | Pilocytic astrocytoma | I | Sellar region | 1 | 1 |
4 | 6 | 12 | M | Pilocytic astrocytoma | I | Right basal ganglia | 1 | 3 |
5 | 13 | 20 | M | Astrocytoma | II | Left frontal | 1 | |
6 | 16 | 13 | M | Ependymoma | II | Left cerebellum | 1 | 1 |
7 | 17 | 20 | F | Astrocytoma | III | Right thalamus | 2 | 4 |
8 | 18 | 21 | F | Astrocytoma | III | Right basal ganglia | 1 | 4 |
9 | 19 | 14 | M | Astrocytoma | III | Left pericentral | 1 | 1 |
10 | 20 | 14 | F | Astrocytoma | III | Right frontal | 1 | 3 |
11 | 22 | 21 | F | Oligoastrocytoma | III | Right internal capsula | 1 | 4 |
12 | 23 | 18 | M | Glioblastoma | IV | Left temporal | 1 | 4 |
13 | 24 | 12 | F | Glioblastoma | IV | Right thalamus | 1 | 4 |
14 | 25 | 20 | F | Medulloblastoma | IV | Left cerebellum | 1 | 4 |
15 | 26 | 10 | F | Medulloblastoma | IV | Right frontal | 1 | 4 |
16 | 27 | 21 | M | Medulloblastoma | IV | Pons | 1 | 1 |
17 | 28 | 8 | F | Medulloblastoma | IV | Right cerebellum | 1 | 2 |
18 | 29 | 11 | F | Ependymoblastoma | IV | Right fronto-temporal | 1 | 3 |
19 | 30 | 2 | F | ATRT | IV | Brainstem | 1 | 2 |
20 | 31 | 9 | M | ATRT | IV | Right temporo-occipital | 1 | 4 |
# | Pat. no. | Age [years] | Gender (F = female M = male) | Diagnosis | WHO grade | Localization | Number of MET-PET scans [n] | Diagnosis confirmed by |
---|---|---|---|---|---|---|---|---|
1 | 11 | 21 | F | Astrocytoma | II | Left temporal | 2 | 4,1 |
2 | 12 | 21 | F | Astrocytoma | II | Left precentral | 2 | 2,1 |
3 | 15 | 10 | M | Pleomorphic xanthoastrocytoma | II | Left temporal | 5 | 1,1 |
4 | 21 | 19 | F | Oligoastrocytoma | III | Left temporo-parietal | 2 | 4,1 |
Methods
Results
Histological diagnosis and WHO grade |
n
|
n
a
| Relative MET-uptake (mean ± SDb) |
---|---|---|---|
Relative MET uptake in different tumors | |||
Pilocytic astrocytoma I | 6 | 6 | 2.11 ± 0.88 |
Astrocytoma II | 6 | 8 | 1.69 ± 0.50 |
Pleomorphic xanthoastrocytoma II | 1 | 5 | 2.23 ± 0.48 |
Astrocytoma III | 4 | 5 | 2.61 ± 0.73 |
Oligoastrocytoma III | 2 | 3 | 2.61 ± 0.24 |
Glioblastoma IV | 2 | 2 | 1.70 ± 0.55 |
Medulloblastoma IV | 4 | 4 | 1.78 ± 0.55 |
Atypical teratoid rhabdoid tumor IV | 2 | 2 | 1.36 ± 0.71 |
Ependymoma II | 1 | 1 | 0.97 |
Ependymoblastoma IV | 1 | 1 | 1.95 |
DNT I | 1 | 1 | 2.04 |
Desmoplastic infantile ganglioglioma I | 1 | 1 | 2.01 |
Non tumor lesions | 8 | 9 | 1.04 ± 0.22 |
Total | 39 | 48 |