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Erschienen in: Journal of Neuro-Oncology 1/2011

01.03.2011 | Clinical Study - Patient Studies

Pseudoprogression in patients with malignant gliomas treated with concurrent temozolomide and radiotherapy: potential role of p53

verfasst von: Hyun-Cheol Kang, Chae-Yong Kim, Jung Ho Han, Ghee Young Choe, Jae Hyoung Kim, Jee Hyun Kim, In Ah Kim

Erschienen in: Journal of Neuro-Oncology | Ausgabe 1/2011

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Abstract

We investigated pseudoprogression (psPD) in patients with malignant gliomas treated with radiotherapy (RT) and maintenance temozolomide (TMZ) in terms of incidence, outcomes, and predictive and prognostic factors. We evaluated p53 overexpression by immunohistochemical analysis of thirty-five tumor samples as a predictor for psPD. The time to progression and overall survival were compared between subgroups, psPD versus early progression (ePD) versus nonprogression (nonPD). Eight patients developed psPD among eighteen patients with lesion enlargement at the first MRI scan, and the others were classified as ePD. The remaining stable or improved patients were classified as nonPD. All patients with psPD were alive at last follow-up (median follow-up period was 12 months; range 5.8–58.5 months). Overall survival of psPD patients was significantly higher than ePD patients (P < 0.01). There was no significant survival difference between the psPD group and nonPD group (P = 0.25). Seven (87.5%) of eight tumors with psPD showed p53 overexpression, as compared to 3 (30%) of the ten tumors with ePD (P = 0.03). Our study indicates that psPD following chemoradiotherapy with TMZ is associated with significantly better overall survival compared to that of ePD, and is comparable to nonPD group. Overexpression of p53 was identified as a potential biomarker for predicting the development of psPD.
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Metadaten
Titel
Pseudoprogression in patients with malignant gliomas treated with concurrent temozolomide and radiotherapy: potential role of p53
verfasst von
Hyun-Cheol Kang
Chae-Yong Kim
Jung Ho Han
Ghee Young Choe
Jae Hyoung Kim
Jee Hyun Kim
In Ah Kim
Publikationsdatum
01.03.2011
Verlag
Springer US
Erschienen in
Journal of Neuro-Oncology / Ausgabe 1/2011
Print ISSN: 0167-594X
Elektronische ISSN: 1573-7373
DOI
https://doi.org/10.1007/s11060-010-0305-7

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