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Erschienen in: Journal of Neuro-Oncology 1/2014

01.08.2014 | Topic Review

Diffuse intrinsic pontine glioma: a reassessment

verfasst von: Nathan J. Robison, Mark W. Kieran

Erschienen in: Journal of Neuro-Oncology | Ausgabe 1/2014

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Abstract

Diffuse intrinsic pontine glioma (DIPG) is a disease of childhood whose abysmal prognosis has remained unchanged for over 50 years. Biologic investigation has been stymied by lack of pretreatment tissue, as biopsy has been reserved for atypical cases. Recent advances in surgical and molecular-analytic techniques have increased the safety and potential utility of biopsy; brainstem biopsy has now been incorporated into several prospective clinical trials. These and other recent efforts have yielded new insights into DIPG molecular pathogenesis, and opened new avenues for investigation.
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Metadaten
Titel
Diffuse intrinsic pontine glioma: a reassessment
verfasst von
Nathan J. Robison
Mark W. Kieran
Publikationsdatum
01.08.2014
Verlag
Springer US
Erschienen in
Journal of Neuro-Oncology / Ausgabe 1/2014
Print ISSN: 0167-594X
Elektronische ISSN: 1573-7373
DOI
https://doi.org/10.1007/s11060-014-1448-8

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