Introduction
Methods
Study population
Data collection
Cerebral structure | Prevalence of involvement in | p value | |||||
---|---|---|---|---|---|---|---|
NT N = 374 | PCNSL N = 26 | M N = 178 | Overall | NT vs. PCNSL | NT vs. M | PCNSL vs. M | |
Lobes | |||||||
Unilobar | 244 (72) | 11 (61) | 126 (74) | 0.520 | – | – | – |
Multilobar | 96 (28) | 7 (39) | 45 (26) | ||||
Frontal | 107 (32) | 13 (72) | 75 (44) | < 0.001* | 0.001* | 0.011 | 0.023 |
Central | 43 (13) | 4 (22) | 43 (25) | 0.001* | 0.487 | 0.001* | 0.775 |
Parietal | 77 (23) | 7 (39) | 48 (28) | 0.154 | – | – | – |
Occipital | 48 (14) | 6 (33) | 40 (24) | 0.007* | 0.054 | 0.025 | 0.358 |
Temporal | 110 (32) | 3 (17) | 27 (16) | < 0.001* | 0.321 | < 0.001* | 0.931 |
Insular | 41 (12) | 4 (22) | 4 (2) | < 0.001* | 0.207 | 0.001* | < 0.001* |
Limbic | 75 (22) | 6 (33) | 12 (7) | < 0.001* | 0.269 | < 0.001* | 0.001* |
Gyral segment | |||||||
Unigyral | 186 (55) | 6 (33) | 120 (70) | < 0.001* | 0.074 | 0.003* | 0.003* |
Multigyral | 153 (45) | 12 (67) | 51 (30) | ||||
Frontal pole | 6 (2) | 1 (4) | 3 (2) | 0.697 | – | – | – |
F1 | 51 (14) | 6 (23) | 31 (17) | 0.268 | – | – | – |
F2 | 37 (10) | 4 (15) | 33 (19) | 0.016 | – | – | – |
F3 | 27 (7) | 4 (15) | 9 (5) | 0.142 | – | – | – |
Orbital | 17 (5) | 1 (4) | 5 (3) | 0.621 | – | – | – |
Rectus | 8 (2) | 1 (4) | 0 (0) | 0.104 | – | – | – |
Rostral | 4 (1) | 0 (0) | 1 (1) | 0.741 | – | – | – |
Subcallosal area | 10 (3) | 2 (8) | 0 (0) | 0.015 | – | – | – |
Precentral | 14 (4) | 1 (4) | 25 (14) | < 0.001* | 0.979 | < 0.001* | 0.290 |
Postcentral | 13 (4) | 1 (4) | 16 (9) | 0.023 | – | – | – |
Paracentral | 10 (3) | 1 (4) | 5 (3) | 0.939 | – | – | – |
Subcentral | 14 (4) | 0 (0) | 5 (3) | 0.534 | – | – | – |
Superior parietal lobule | 16 (4) | 1 (4) | 14 (8) | 0.204 | – | – | – |
Supramarginal | 32 (9) | 1 (4) | 13 (7) | 0.642 | – | – | – |
Angular | 22 (6) | 1 (4) | 10 (6) | 0.909 | – | – | – |
Precuneus | 26 (7) | 3 (12) | 13 (7) | 0.684 | – | – | – |
Cuneus | 13 (4) | 2 (8) | 8 (4) | 0.520 | – | – | – |
O1 | 9 (2) | 1 (4) | 6 (3) | 0.766 | – | – | – |
O2 | 20 (5) | 0 (0) | 15 (8) | 0.152 | – | – | – |
O3 | 8 (2) | 0 (0) | 6 (3) | 0.484 | – | – | – |
Occipital pole | 1 (0) | 0 (0) | 1 (1) | 0.820 | – | – | – |
Lingual | 13 (3) | 0 (0) | 9 (5) | 0.387 | – | – | – |
Fusiform | 32 (9) | 0 (0) | 6 (3) | 0.027 | – | – | – |
T1 | 44 (12) | 0 (0) | 6 (3) | 0.001* | 0.128 | 0.004* | 0.342 |
T2 | 37 (10) | 0 (0) | 7 (4) | 0.015 | – | – | – |
T3 | 30 (8) | 0 (0) | 5 (3) | 0.023 | – | – | – |
Temporal pole | 28 (7) | 0 (0) | 2 (1) | 0.003* | 0.296 | 0.006* | 0.587 |
Short insular | 28 (7) | 4 (15) | 0 (0) | < 0.001* | 0.151 | < 0.001* | < 0.001* |
Long insular | 31 (8) | 4 (15) | 1 (1) | < 0.001* | 0.216 | 0.001* | < 0.001* |
Parahippocampal | 30 (8) | 1 (4) | 0 (0) | < 0.001* | 0.441 | < 0.001* | 0.017* |
Cingulate | 47 (13) | 3 (12) | 9 (5) | 0.024 | – | – | – |
Cortical involvement | 325 (87) | 6 (23) | 169 (95) | < 0.001* | < 0.001* | 0.004* | < 0.001* |
WM (peripheral) | 330 (88) | 17 (65) | 170 (96) | < 0.001* | 0.002* | 0.006* | < 0.001* |
Subcortical sector | 313 (84) | 16 (62) | 169 (95) | < 0.001* | 0.004* | < 0.001* | < 0.001* |
Subgyral sector | 314 (84) | 14 (54) | 118 (66) | < 0.001* | < 0.001* | < 0.001* | 0.215 |
Gyral sector | 305 (82) | 12 (46) | 47 (26) | < 0.001* | < 0.001* | < 0.001* | 0.038 |
Lobar sector | 288 (77) | 11 (42) | 18 (10) | < 0.001* | < 0.001* | < 0.001* | < 0.001* |
Corpus callosum | 55 (15) | 12 (46) | 2 (1) | < 0.001* | < 0.001* | < 0.001* | < 0.001* |
Capsule | 31 (8) | 11 (42) | 3 (2) | < 0.001* | < 0.001* | 0.003 | < 0.001* |
Internal capsule | 2 (1) | 10 (38) | 2 (1) | < 0.001* | < 0.001* | 0.446 | < 0.001* |
External capsule | 26 (7) | 10 (38) | 2 (1) | < 0.001* | < 0.001* | 0.004* | < 0.001* |
Extreme capsule | 30 (8) | 10 (38) | 2 (1) | < 0.001* | < 0.001* | 0.001* | < 0.001* |
Deep gray matter | 82 (22) | 10 (38) | 10 (6) | < 0.001* | 0.053 | < 0.001* | < 0.001* |
Caudate nucleus | 4 (1) | 6 (23) | 2 (1) | < 0.001* | < 0.001* | 0.954 | < 0.001* |
Putamen | 4 (1) | 5 (19) | 2 (1) | < 0.001* | < 0.001* | 0.954 | < 0.001* |
Globus pallidus | 5 (1) | 5 (19) | 1 (1) | < 0.001* | < 0.001* | 0.412 | < 0.001* |
Claustrum | 23 (6) | 6 (23) | 2 (1) | < 0.001* | 0.003* | 0.008* | < 0.001* |
Hypothalamus | 17 (5) | 5 (19) | 0 (0) | < 0.001* | 0.004* | 0.004* | < 0.001* |
Thalamus | 28 (7) | 5 (19) | 5 (3) | 0.003* | 0.061 | 0.061 | 0.001* |
Amygdala | 35 (9) | 2 (8) | 1 (1) | < 0.001* | 0.777 | < 0.001* | 0.010* |
Hippocampus | 43 (11) | 2 (8) | 1 (1) | < 0.001* | 0.553 | < 0.001* | 0.010* |
Ventricular wall | 330 (88) | 17 (65) | 19 (11) | < 0.001* | 0.001* | < 0.001* | < 0.001* |
Unisegmental | 209 (63) | 3 (18) | 16 (80) | < 0.001* | < 0.001* | 0.123 | < 0.001* |
Multisegmental | 123 (37) | 14 (82) | 4 (20) | ||||
Frontal horn | 106 (28) | 9 (35) | 5 (3) | < 0.001* | 0.494 | < 0.001* | < 0.001* |
Body | 80 (21) | 13 (50) | 4 (2) | < 0.001* | 0.001* | < 0.001* | < 0.001* |
Atrium | 168 (45) | 13 (50) | 7 (4) | < 0.001* | 0.615 | < 0.001* | < 0.001* |
Occipital horn | 52 (14) | 6 (23) | 6 (3) | < 0.001* | 0.199 | < 0.001* | < 0.001* |
Temporal horn | 101 (27) | 7 (27) | 4 (2) | < 0.001* | 0.933 | < 0.001* | < 0.001* |
3rd ventricle | 30 (8) | 7 (27) | 2 (1) | < 0.001* | 0.002* | 0.002* | < 0.001* |