Abstract
The density of the serotonin transporter in the plasma membranes of blood platelets was evaluated by labelled paroxetine binding in three different groups. These groups were: normal controls, epileptic patients having undergone a recent seizure (less than 4 days before) and patients who equally recently presented psychogenic non-epileptic seizures (pseudoseizures). Real seizures resulted in a significant decrease of membrane serotonin transporter density. In the instances of pseudoseizures, its membrane density was undistinguishable from that of normal controls. These data lend further support to the idea that down regulation of serotonin transporter may play a homeostatic role in the cessation of epileptic seizures.
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Scudder CL, Karczmar AG, Everett GM et al (1966) Brain cathecolamines and serotonin values in various strains and genera of mice and a possibile interpretation for the correlation of amine with electroshock latency and behaviour. Int J Neuropharmacol 5:343–351
Yan QS, Jobe PC, Dailey JW (1993) Evidence that a serotonergic mechanism is involved in the anticonvulsant effect of fluoxetine in genetically epilepsy-prone rats. Eur J Pharmacol 252:105–112
Jobe PC, Browning RA (2005) The serotonergic and noradrenergic effects of antidepressant drugs are anticonvulsant not proconvulsant. Epilepsy Behav 7:602–619
Bagdy G, Kecskemeti V, Riba P et al (2007) Serotonin and Epilepsy. J Neurochem 100:857–873
Leander JD (1992) Fluoxetine, a selective serotonin uptake inhibitor, enhances the anticonvulsant effects of phenytoin, carbamazepine and ameltolide. Epilepsia 33:573–576
Pasini A, Tortorella A, Gale K (1992) Anticonvulsant action of intranigral fluoxetine. Brain Res 593:287–290
Prendeville S, Gale K (1993) Anticonvulsant effect of fluoxetine on focally evoked limbic motor seizures in rats. Epilepsia 34:381–384
Wada Y, Shiraishi J, Nakamura M et al (1995) Prolonged but not acute fluoxetine administration produces the inhibitory effect on hippocampal seizures in rats. Psychopharmacology 118:305–309
Favale E, Rubino V, Mainardi P et al (1995) Anticonvulsant effect of fluoxetine in humans. Neurology 45:1926–1927
Favale E, Audenino D, Cocito L et al (2003) The anticonvulsant effect of citalopram as an indirect evidence of serotoninergic impairment in human epileptogenesis. Seizure 12:316–318
Paul SM, Rehavi M, Skolnick P et al (1981) Depressed patients have decreased binding of tritiated imipramine to platelet serotonin “transporter”. Arch Gen Psychiat 38:1315–1317
Langer SZ, Zarifian E, Briley M et al (1982) High-affinity 3H-imipramine binding: a new biological marker in depression. Pharmacopsychiatria 15:4–10
Langer SZ, Galzin AM, Poirier MF et al (1987) Association of [3H]-imipramine and [3H]-paroxetine binding with the 5HT transporter in brain and platelets: relevance to studies in depression. J Recept Res 7:499–521
Mellerup ET, Errebo I, Molin J et al (1993) Platelet paroxetine binding and light therapy in winter depression. J Affect Disord 29:11–15
Uebelhack R, Franke L, Herold N et al (2006) Brain and platelet serotonin transporter in humans-orrelation between [123I]-ADAM SPECT and serotonergic measurements in platelets. Neurosci Lett 406:153–158
Da Prada M, Cesura AM, Launay JM et al (1988) Platelets as a model for neurones? Experientia 44:115–126
Lesch KP, Wolozin BL, Murphy DL et al (1993) Primary structure of human platelet serotonin uptake site: identity with the brain serotonin transporter. J Neurochem 60:2319–2322
Rausch Jl, Johnson ME, Li J et al (2005) Serotonin transport kinetics correlated between human platelets and brain synaptosomes. Psychopharmacology 180:391–398
Cupello A, Favale E, Audenino D et al (2005) Decrease of serotonin transporters in blood platelets after epileptic seizures. Neurochem Res 30:425–428
Albano C, Cupello A, Mainardi P et al (2006) Successful treatment of epilepsy with serotonin reuptake inhibitors: proposed mechanism. Neurochem Res 31:509–514
Lesser RP (2003) Treatment and outcome of psychogenic nonepileptic seizures. Epilepsy Curr 3:198–200
Reuber M, Fernandez G, Bauer J et al (2002) Diagnostic delay in psychogenic nonepileptic seizures. Neurology 58:493–495
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Cupello, A., Audenino, D., Scarrone, S. et al. Epileptic Seizures but not Pseudoseizures are Associated with Decreased Density of the Serotonin Transporter in Blood Platelet Membranes. Neurochem Res 33, 2263–2268 (2008). https://doi.org/10.1007/s11064-008-9708-7
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DOI: https://doi.org/10.1007/s11064-008-9708-7