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Cellular Elements of the Blood-Brain Barrier

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Abstract

The Blood-brain-barrier (BBB) provides both anatomical and physiological protection for the central nervous system (CNS), shielding the brain for toxic substances in the blood, supplying brain tissues with nutrients and filtering harmful compounds from the brain back to the bloodstream. The BBB is composed of four main cellular elements: endothelial cells (ECs), astrocyte end-feet, microglial cells, and perycites. Transport across the BBB is limited by both physical and metabolic barriers (enzymes, and different transport systems). Tight junctions (TJs) present between ECs form an important barrier against diffusion, excluding most blood-borne substances for entering the brain.

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Acknowledgments

We thank Adriana Zufriategui for preparation of the figures.

Author information

Authors and Affiliations

  1. Department of Neurology, Institute for Neurological Research Dr. Raúl Carrea (FLENI), Montañeses 2325, 1428, Buenos Aires, Argentina

    Jorge Correale

  2. School of Biomedical Sciences, Austral University, Montañeses 2325, 1428, Buenos Aires, Argentina

    Jorge Correale

  3. Department of Neurology, José María Ramos Mejía Hospital, School of Medicine Buenos Aires University, Urquiza 609, 1221, Buenos Aires, Argentina

    Andrés Villa

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  1. Jorge Correale
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  2. Andrés Villa
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Correspondence to Jorge Correale.

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Correale, J., Villa, A. Cellular Elements of the Blood-Brain Barrier. Neurochem Res 34, 2067–2077 (2009). https://doi.org/10.1007/s11064-009-0081-y

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