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Proline-Rich Hypothalamic Polypeptide Has Opposite Effects on the Proliferation of Human Normal Bone Marrow Stromal Cells and Human Giant-cell Tumour Stromal Cells

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An Erratum to this article was published on 19 March 2010

Abstract

In the present study we carried out experiments in vitro and in vivo and investigated the effect of proline-rich polypeptide (PRP) on the proliferation and effectiveness of colony formation of MMSCs in vitro. Various routes and doses of PRP administration to rats increased the number of MMSCs in bone marrow and spleen. Our research revealed opposite effects of PRP on the proliferation of bone marrow stromal cells obtained from normal humans and stromal cells isolated from a human giant-cell tumour.

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Acknowledgments

Authors express profound gratitude to Ac.A.A. Galoyan for kindly furnished PRP preparation as well as for his participation and interest to our work and discussion of obtained results.

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Authors and Affiliations

  1. Gamaleya Research Institute of Epidemiology and Microbiology, Russian Academy of Medical Sciences, Gamaleya str., 18, 123098, Moscow, Russian Federation

    R. K. Chailakhyan, Yu. V. Gerasimov & M. R. Chailakhyan

Authors
  1. R. K. Chailakhyan
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  2. Yu. V. Gerasimov
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  3. M. R. Chailakhyan
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Corresponding author

Correspondence to R. K. Chailakhyan.

Additional information

Special issue article in honor of Professor Armen Galoyan.

An erratum to this article can be found at http://dx.doi.org/10.1007/s11064-010-0149-8

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Chailakhyan, R.K., Gerasimov, Y.V. & Chailakhyan, M.R. Proline-Rich Hypothalamic Polypeptide Has Opposite Effects on the Proliferation of Human Normal Bone Marrow Stromal Cells and Human Giant-cell Tumour Stromal Cells. Neurochem Res 35, 934–939 (2010). https://doi.org/10.1007/s11064-009-0113-7

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  • DOI: https://doi.org/10.1007/s11064-009-0113-7

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