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Pituitary

Erschienen in:

22.08.2019

Craniopharyngiomas presenting as incidentalomas: results of KRANIOPHARYNGEOM 2007

verfasst von: Svenja Boekhoff, Brigitte Bison, Maria Eveslage, Panjarat Sowithayasakul, Hermann L. Müller

Erschienen in: Pituitary | Ausgabe 5/2019

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Abstract

Purpose

Childhood-onset craniopharyngiomas (CP) are diagnosed due to clinical symptoms (symCP) or incidentally (incCP). We investigated clinical manifestations and outcome in incCPs and symCPs.

Methods

IncCP were discovered in 4 (3 m/1 f) and symCP in 214 (101 m/113 f) CP recruited 2007–2014 in KRANIOPHARYNGEOM 2007. Age, sex, height, body mass index (BMI), tumor volume, degree of resection, pre- and postsurgical hypothalamic involvement/lesions, pituitary function and outcome were compared between both subgroups.

Results

Reasons for imaging in incCP were cerebral palsy, head trauma, nasal obstruction, and tethered-cord syndrome, whereas headache (44%), visual impairment (25%), and growth retardation (17%) lead to imaging in symCP. Tumor volume at diagnosis was smaller in incCP (median 2.39 cm³; range 0.14–4.10 cm³) when compared with symCP (15.86 cm³; 0.002–286.34 cm³). Age, gender, BMI, height, hydrocephalus, tumor location, and hypothalamic involvement at diagnosis of incCP were within the range of these parameters in symCP. Complete resections were achieved more frequently (3/4 patients) in incCP when compared with symCP (20%). Surgical hypothalamic lesions were distributed similar in incCP and symCP. Irradiation was performed only in symCP (33%). No noticeable differences were observed concerning survival rates, endocrine deficiencies, BMI, height, functional capacity and quality of life of the 4 incCP cases when compared with the symCP cohort.

Conclusions

IncCP are rare (1.8%) and characterized by lack of endocrine deficiencies, resulting in normal height and BMI, no hydrocephalus, and smaller tumor volume at diagnosis when compared with symCPs. Outcome of the observed incCP is similar with symCP.

Clinical trial registration number: NCT01272622.

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Titel: Craniopharyngiomas presenting as incidentalomas: results of KRANIOPHARYNGEOM 2007
verfasst von: Svenja Boekhoff
Brigitte Bison
Maria Eveslage
Panjarat Sowithayasakul
Hermann L. Müller
Publikationsdatum: 22.08.2019
Verlag: Springer US
Erschienen in: Pituitary / Ausgabe 5/2019
Print ISSN: 1386-341X
Elektronische ISSN: 1573-7403
DOI: https://doi.org/10.1007/s11102-019-00983-7

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Craniopharyngiomas presenting as incidentalomas: results of KRANIOPHARYNGEOM 2007

Abstract

Purpose

Methods

Results

Conclusions

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