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Pituitary

Erschienen in:

29.06.2020 | Surgery

Prognostic factors of biochemical remission after transsphenoidal surgery for acromegaly: a structured review

verfasst von: Nidhi Agrawal, Adriana G. Ioachimescu

Erschienen in: Pituitary | Ausgabe 5/2020

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Abstract

Purpose

Biochemical control is the main determinant of survival, clinical manifestations and comorbidities in acromegaly. Transsphenoidal selective adenomectomy (TSA) is the initial treatment of choice with reported biochemical remission rates varying between 32 and 85%. Understanding the limiting factors is essential for identification of patients who require medical treatment.

Methods

We reviewed the English literature published in Medline/Pubmed until Dec 31, 2019 to identify eligible studies that described outcomes of TSA as primary therapy and performed analyses to determine the main predictors of remission.

Results

Most publications reported single-institution, retrospective studies. The following preoperative parameters were consistently associated with lower remission rates: cavernous sinus invasion by imaging, larger tumor size and higher GH levels. Young age and preoperative IGF-1 levels were predictive in some studies. When controlled for covariates, the best single preoperative predictor was cavernous sinus invasion, followed by preoperative GH levels. Conversely, low GH level in the first few days postoperatively was a robust predictor of durable remission. The influence of tumor histology (sparsely granular pattern, co-expression of prolactin and proliferation markers) on surgical remission remains to be established. Few studies developed predictive models that yielded much higher predictive values than individual parameters.

Conclusion

Surgical outcome prognostication systems could be further generated by machine learning algorithms in order to support development and implementation of personalized care in patients with acromegaly.

Katznelson L, Laws ER Jr, Melmed S, Molitch ME, Murad MH, Utz A, Wass JA, Endocrine S (2014) Acromegaly: an endocrine society clinical practice guideline. J Clin Endocrinol Metabol 99(11):3933–3951. https://doi.org/10.1210/jc.2014-2700CrossRef

Bolfi F, Neves AF, Boguszewski CL, Nunes-Nogueira VS (2018) Mortality in acromegaly decreased in the last decade: a systematic review and meta-analysis. Eur J Endocrinol 179(1):59–71. https://doi.org/10.1530/EJE-18-0255CrossRefPubMed

Mercado M, Gonzalez B, Vargas G, Ramirez C, de los Monteros AL, Sosa E, Jervis P, Roldan P, Mendoza V, Lopez-Felix B, Guinto G. (2014). Successful mortality reduction and control of comorbidities in patients with acromegaly followed at a highly specialized multidisciplinary clinic. J Clin Endocrinol Metabol, 99(12): 4438–4446

Giustina A, Barkan A, Beckers A, Biermasz N, Biller BMK, Boguszewski C, Bolanowski M, Bonert V, Bronstein MD, Casanueva FF, Clemmons D, Colao A, Ferone D, Fleseriu M, Frara S, Gadelha MR, Ghigo E, Gurnell M, Heaney AP, Ho K, Ioachimescu A, Katznelson L, Kelestimur F, Kopchick J, Krsek M, Lamberts S, Losa M, Luger A, Maffei P, Marazuela M, Mazziotti G, Mercado M, Mortini P, Neggers S, Pereira AM, Petersenn S, Puig-Domingo M, Salvatori R, Shimon I, Strasburger C, Tsagarakis S, van der Lely AJ, Wass J, Zatelli MC, Melmed S (2019) A consensus on the diagnosis and treatment of acromegaly comorbidities: an update. J Clin Endocrinol Metabol. https://doi.org/10.1210/clinem/dgz096CrossRef

Babu H, Ortega A, Nuno M, Dehghan A, Schweitzer A, Bonert HV, Carmichael JD, Cooper O, Melmed S, Mamelak AN (2017) Long-term endocrine outcomes following endoscopic endonasal transsphenoidal surgery for acromegaly and associated prognostic factors. Neurosurgery 81(2):357–366. https://doi.org/10.1093/neuros/nyx020CrossRefPubMed

Donegan DM, Iniguez-Ariza N, Sharma A, Nippoldt T, Young W, Van Gompel J, Atkinson J, Meyer F, Pollock B, Natt N, Laack N, Erickson D (2018) Necessity of multimodal treatment of acromegaly and outcomes. Endocr Pract 24(7):668–676. https://doi.org/10.4158/ep-2018-0040CrossRefPubMed

Kasuki L, Wildemberg LE, Gadelha MR (2018) Management of endocrine disease: personalized medicine in the treatment of acromegaly. Eur J Endocrinol 178(3):R89–R100. https://doi.org/10.1530/EJE-17-1006CrossRefPubMed

Delemer B, Chanson P, Foubert L, Borson-Chazot F, Chabre O, Tabarin A, Weryha G, Cortet-Rudelli C, Raingeard I, Reznik Y, Reines C, Bisot-Locard S, Castinetti F (2014) Patients lost to follow-up in acromegaly: results of the ACROSPECT study. Eur J Endocrinol 170(5):791–797. https://doi.org/10.1530/EJE-13-0924CrossRefPubMed

Yamada S, Aiba T, Sano T, Kovacs K, Shishiba Y, Sawano S, Takada K (1993) Growth hormone-producing pituitary adenomas: correlations between clinical characteristics and morphology. Neurosurgery 33(1):20–27PubMed

10.

Jenkins D, O'Brien I, Johnson A, Shakespear R, Sheppard MC, Stewart PM (1995) The birmingham pituitary database: auditing the outcome of the treatment of acromegaly. Clin Endocrinol 43(5):517–522. https://doi.org/10.1111/j.1365-2265.1995.tb02913.xCrossRef

11.

Gittoes NJ, Sheppard MC, Johnson AP, Stewart PM (1999) Outcome of surgery for acromegaly–the experience of a dedicated pituitary surgeon. QJM 92(12):741–745. https://doi.org/10.1093/qjmed/92.12.741CrossRefPubMed

12.

Valdemarsson S, Ljunggren S, Bramnert M, Norrhamn O, Nordstrom CH (2000) Early postoperative growth hormone levels: high predictive value for long-term outcome after surgery for acromegaly. J Intern Med 247(6):640–650CrossRef

13.

Bakhtiar Y, Hirano H, Arita K, Yunoue S, Fujio S, Tominaga A, Sakoguchi T, Sugiyama K, Kurisu K, Yasufuku-Takano J, Takano K (2010) Relationship between cytokeratin staining patterns and clinico-pathological features in somatotropinomae. Eur J Endocrinol 163(4):531–539. https://doi.org/10.1530/EJE-10-0586CrossRefPubMed

14.

Kiseljak-Vassiliades K, Carlson NE, Borges MT, Kleinschmidt-DeMasters BK, Lillehei KO, Kerr JM, Wierman ME (2015) Growth hormone tumor histological subtypes predict response to surgical and medical therapy. Endocrine 49(1):231–241. https://doi.org/10.1007/s12020-014-0383-yCrossRefPubMed

15.

Rick J, Jahangiri A, Flanigan PM, Chandra A, Kunwar S, Blevins L, Aghi MK (2018) Growth hormone and prolactin-staining tumors causing acromegaly: a retrospective review of clinical presentations and surgical outcomes. J Neurosurg. https://doi.org/10.3171/2018.4.JNS18230CrossRefPubMed

16.

Taghvaei M, Sadrehosseini SM, Ardakani JB, Nakhjavani M, Zeinalizadeh M (2018) Endoscopic endonasal approach to the growth hormone-secreting pituitary adenomas: endocrinologic outcome in 68 patients. World Neurosurg 117:e259–e268. https://doi.org/10.1016/j.wneu.2018.06.009CrossRefPubMed

17.

Wagenmakers MA, Netea-Maier RT, van Lindert EJ, Pieters GF, Grotenhuis AJ, Hermus AR (2011) Results of endoscopic transsphenoidal pituitary surgery in 40 patients with a growth hormone-secreting macroadenoma. Acta Neurochir 153(7):1391–1399. https://doi.org/10.1007/s00701-011-0959-8CrossRefPubMed

18.

Starnoni D, Daniel RT, Marino L, Pitteloud N, Levivier M, Messerer M (2016) Surgical treatment of acromegaly according to the 2010 remission criteria: systematic review and meta-analysis. Acta Neurochir 158(11):2109–2121. https://doi.org/10.1007/s00701-016-2903-4CrossRefPubMed

19.

Phan K, Xu J, Reddy R, Kalakoti P, Nanda A, Fairhall J (2017) Endoscopic endonasal versus microsurgical transsphenoidal approach for growth hormone-secreting pituitary adenomas-systematic review and meta-analysis. World Neurosurg 97:398–406. https://doi.org/10.1016/j.wneu.2016.10.029CrossRefPubMed

20.

Briceno V, Zaidi HA, Doucette JA, Onomichi KB, Alreshidi A, Mekary RA, Smith TR (2017) Efficacy of transsphenoidal surgery in achieving biochemical cure of growth hormone-secreting pituitary adenomas among patients with cavernous sinus invasion: a systematic review and meta-analysis. Neurol Res 39(5):387–398. https://doi.org/10.1080/01616412.2017.1296653CrossRefPubMed

21.

Chen CJ, Ironside N, Pomeraniec IJ, Chivukula S, Buell TJ, Ding D, Taylor DG, Dallapiazza RF, Lee CC, Bergsneider M (2017) Microsurgical versus endoscopic transsphenoidal resection for acromegaly: a systematic review of outcomes and complications. Acta Neurochir 159(11):2193–2207. https://doi.org/10.1007/s00701-017-3318-6CrossRefPubMed

22.

Yamada S, Shishiba Y, Kitano M, Seki Y, Umezu H, Umezu Y, Ohtsuki N, Yamazaki Y, Aiba T (1985) Decrease in human growth hormone (HGH) levels during transsphenoidal surgery for acromegaly as a guide for prognosis. Endocrinol Jpn 32(6):899–906. https://doi.org/10.1507/endocrj1954.32.899CrossRefPubMed

23.

Minniti G, Jaffrain-Rea ML, Esposito V, Santoro A, Tamburrano G, Cantore G (2003) Evolving criteria for post-operative biochemical remission of acromegaly: can we achieve a definitive cure? An audit of surgical results on a large series and a review of the literature. Endocr Relat Cancer 10(4):611–619CrossRef

24.

Feelders RA, Bidlingmaier M, Strasburger CJ, Janssen JA, Uitterlinden P, Hofland LJ, Lamberts SW, van der Lely AJ, de Herder WW (2005) Postoperative evaluation of patients with acromegaly: clinical significance and timing of oral glucose tolerance testing and measurement of (free) insulin-like growth factor I, acid-labile subunit, and growth hormone-binding protein levels. J Clin Endocrinol Metabol 90(12):6480–6489. https://doi.org/10.1210/jc.2005-0901CrossRef

25.

Abbassioun K, Amirjamshidi M, Mehrazin A, Khalatbary I, Keynama M, Bokai H, Abdollahi M. (2016). A prospective analysis of 151 cases of patients with acromegaly operated by one neurosurgeon: a follow-up of more than 23 years. Surg Neurol, 66(1), 26–31; discussion 31, 10.1016/j.surneu.2005.11.063

26.

Campbell PG, Kenning E, Andrews DW, Yadla S, Rosen M, Evans JJ (2010) Outcomes after a purely endoscopic transsphenoidal resection of growth hormone-secreting pituitary adenomas. Neurosurg Focus 29(4):E5. https://doi.org/10.3171/2010.7.FOCUS10153CrossRefPubMed

27.

Wang YY, Higham C, Kearney T, Davis JR, Trainer P, Gnanalingham KK (2012) Acromegaly surgery in Manchester revisited–the impact of reducing surgeon numbers and the 2010 consensus guidelines for disease remission. Clin Endocrinol 76(3):399–406. https://doi.org/10.1111/j.1365-2265.2011.04193.xCrossRef

28.

Starke RM, Raper DM, Payne SC, Vance ML, Oldfield EH, Jane JA Jr (2013) Endoscopic vs microsurgical transsphenoidal surgery for acromegaly: outcomes in a concurrent series of patients using modern criteria for remission. J Clin Endocrinol Metabol 98(8):3190–3198. https://doi.org/10.1210/jc.2013-1036CrossRef

29.

Dutta P, Korbonits M, Sachdeva N, Gupta P, Srinivasan A, Devgun JS, Bajaj A, Mukherjee KK (2016) Can immediate postoperative random growth hormone levels predict long-term cure in patients with acromegaly? Neurol India 64(2):252–258. https://doi.org/10.4103/0028-3886.177622CrossRefPubMed

30.

Bates PR, Carson MN, Trainer PJ, Wass JA, Group U.K.N.A.R.S (2008) Wide variation in surgical outcomes for acromegaly in the UK. Clin Endocrinol 68(1):136–142. https://doi.org/10.1111/j.1365-2265.2007.03012.xCrossRef

31.

Hofstetter CP, Mannaa RH, Mubita L, Anand VK, Kennedy JW, Dehdashti AR, Schwartz TH (2010) Endoscopic endonasal transsphenoidal surgery for growth hormone-secreting pituitary adenomas. Neurosurg Focus 29(4):E6. https://doi.org/10.3171/2010.7.FOCUS10173CrossRefPubMed

32.

Kim JH, Hur KY, Lee JH, Lee JH, Se YB, Kim HI, Lee SH, Nam DH, Kim SY, Kim KW, Kong DS, Kim YH (2017) Outcome of endoscopic transsphenoidal surgery for acromegaly. World Neurosurg 104:272–278. https://doi.org/10.1016/j.wneu.2017.04.141CrossRefPubMed

33.

Tindall GT, Oyesiku NM, Watts NB, Clark RV, Christy JH, Adams DA (1993) Transsphenoidal adenomectomy for growth hormone-secreting pituitary adenomas in acromegaly: outcome analysis and determinants of failure. J Neurosurg 78(2):205–215. https://doi.org/10.3171/jns.1993.78.2.0205CrossRefPubMed

34.

Sheaves R, Jenkins P, Blackburn P, Huneidi AH, Afshar F, Medbak S, Grossman AB, Besser GM, Wass JA (1996) Outcome of transsphenoidal surgery for acromegaly using strict criteria for surgical cure. Clin Endocrinol 45(4):407–413. https://doi.org/10.1046/j.1365-2265.1996.8370847.xCrossRef

35.

Freda PU, Wardlaw SL, Post KD (1998) Long-term endocrinological follow-up evaluation in 115 patients who underwent transsphenoidal surgery for acromegaly. J Neurosurg 89(3):353–358. https://doi.org/10.3171/jns.1998.89.3.0353CrossRefPubMed

36.

Ahmed S, Elsheikh M, Stratton IM, Page RC, Adams CB, Wass JA (1999) Outcome of transphenoidal surgery for acromegaly and its relationship to surgical experience. Clin Endocrinol 50(5):561–567CrossRef

37.

Abosch A, Tyrrell JB, Lamborn KR, Hannegan LT, Applebury CB, Wilson CB (1998) Transsphenoidal microsurgery for growth hormone-secreting pituitary adenomas: initial outcome and long-term results. J Clin Endocrinol Metabol 83(10):3411–3418. https://doi.org/10.1210/jcem.83.10.5111CrossRef

38.

Krieger MD, Couldwell WT, Weiss MH (2003) Assessment of long-term remission of acromegaly following surgery. J Neurosurg 98(4):719–724. https://doi.org/10.3171/jns.2003.98.4.0719CrossRefPubMed

39.

Nomikos P, Buchfelder M, Fahlbusch R (2005) The outcome of surgery in 668 patients with acromegaly using current criteria of biochemical 'cure'. Eur J Endocrinol 152(3):379–387. https://doi.org/10.1530/eje.1.01863CrossRefPubMed

40.

Otani R, Fukuhara N, Ochi T, Oyama K, Yamada S (2012) Rapid growth hormone measurement during transsphenoidal surgery: analysis of 252 acromegalic patients. Neurol Med Chir 52(8):558–562. https://doi.org/10.2176/nmc.52.558CrossRef

41.

Demir O, Gedik V, Corapcioglu D, Emral R, Unlu MA, Erdogan MF, Gullu S, Uysal AR, Baskal N (2012) Improvement in remission rates of the first operation in acromegalic patients. Turk Neurosurg 22(5):645–650. https://doi.org/10.5137/1019-5149.JTN.6045-12.0CrossRefPubMed

42.

Kim EH, Oh MC, Lee EJ, Kim SH. (2012). Predicting long-term remission by measuring immediate postoperative growth hormone levels and oral glucose tolerance test in acromegaly. Neurosurgery, 70(5): 1106–1113, discussion 1113, 10.1227/NEU.0b013e31823f5c16

43.

Wang M, Mou C, Jiang M, Han L, Fan S, Huan C, Qu X, Han T, Qu Y, Xu G (2012) The characteristics of acromegalic patients with hyperprolactinemia and the differences in patients with merely GH-secreting adenomas: clinical analysis of 279 cases. Eur J Endocrinol 166(5):797–802. https://doi.org/10.1530/EJE-11-1119CrossRefPubMed

44.

Ku CR, Kim EH, Oh MC, Lee EJ, Kim SH. (2012). Surgical and endocrinological outcomes in the treatment of growth hormone-secreting pituitary adenomas according to the shift of surgical paradigm. Neurosurgery 71(2 Suppl Operative), ons192–203, discussion ons203, 10.1227/NEU.0b013e318265a288

45.

Hazer DB, Isik S, Berker D, Guler S, Gurlek A, Yucel T, Berker M (2013) Treatment of acromegaly by endoscopic transsphenoidal surgery: surgical experience in 214 cases and cure rates according to current consensus criteria. J Neurosurg 119(6):1467–1477. https://doi.org/10.3171/2013.8.JNS13224CrossRefPubMed

46.

Albarel F, Castinetti F, Morange I, Conte-Devolx B, Gaudart J, Dufour H, Brue T (2013) Outcome of multimodal therapy in operated acromegalic patients, a study in 115 patients. Clin Endocrinol 78(2):263–270. https://doi.org/10.1111/j.1365-2265.2012.04492.xCrossRef

47.

Nishioka H, Fukuhara N, Yamaguchi-Okada M, Takeshita A, Takeuchi Y, Yamada S (2017) Pitfalls in early biochemical evaluation after transsphenoidal surgery in patients with acromegaly. Endocr J 64(11):1073–1078. https://doi.org/10.1507/endocrj.EJ17-0261CrossRefPubMed

48.

Sala E, Ferrante E, Locatelli M, Rampini P, Mantovani G, Giavoli C, Filopanti M, Verrua E, Malchiodi E, Carrabba G, Arosio M, Beck-Peccoz P, Spada A, Lania AG (2014) Diagnostic features and outcome of surgical therapy of acromegalic patients: experience of the last three decades. Hormones 13(1):95–103. https://doi.org/10.1007/BF03401325CrossRefPubMed

49.

Shirvani M, Motiei-Langroudi R (2014) Transsphenoidal surgery for growth hormone-secreting pituitary adenomas in 130 patients. World Neurosurg 81(1):125–130. https://doi.org/10.1016/j.wneu.2013.01.021CrossRefPubMed

50.

Sarkar S, Jacob KS, Pratheesh R, Chacko AG. (2014). Transsphenoidal surgery for acromegaly: predicting remission with early postoperative growth hormone assays. Acta Neurochirurgica, 156(7), 1379–1387, discussion 1387, 10.1007/s00701–014–2098–5

51.

Haliloglu O, Kuruoglu E, Ozkaya HM, Keskin FE, Gunaldi O, Oz B, Gazioglu N, Kadioglu P, Tanriover N (2016) Multidisciplinary approach for acromegaly: a single tertiary center’s experience. World Neurosurg 88:270–276. https://doi.org/10.1016/j.wneu.2015.12.092CrossRefPubMed

52.

Park HH, Kim EH, Ku CR, Lee EJ, Kim SH (2018) Outcomes of aggressive surgical resection in growth hormone-secreting pituitary adenomas with cavernous sinus invasion. World Neurosurg 117:e280–e289. https://doi.org/10.1016/j.wneu.2018.06.012CrossRefPubMed

53.

Park SH, Ku CR, Moon JH, Kim EH, Kim SH, Lee EJ (2018) Age- and sex-specific differences as predictors of surgical remission among patients with acromegaly. J Clin Endocrinol Metabol 103(3):909–916. https://doi.org/10.1210/jc.2017-01844CrossRef

54.

Anik I, Cabuk B, Gokbel A, Selek A, Cetinarslan B, Anik Y, Ceylan S (2017) Endoscopic transsphenoidal approach for acromegaly with remission rates in 401 patients: 2010 consensus criteria. World Neurosurg 108:278–290. https://doi.org/10.1016/j.wneu.2017.08.182CrossRefPubMed

55.

Fan Y, Jiang S, Hua M, Feng S, Feng M, Wang R (2019) Machine learning-based radiomics predicts radiotherapeutic response in patients with acromegaly. Front Endocrinol 10:588. https://doi.org/10.3389/fendo.2019.00588CrossRef

56.

Xia Z, Guo X, Zhou Q, Wu J, Lian W, Yao Y, Deng K, Feng M, Wang R, Xing B (2018) Somatotrophic adenoma in children younger than 14 years: clinical features and treatment of 22 cases at a large pituitary center. World Neurosurg 112:e561–e568. https://doi.org/10.1016/j.wneu.2018.01.087CrossRefPubMed

57.

Giustina A, Chanson P, Bronstein MD, Klibanski A, Lamberts S, Casanueva FF, Trainer P, Ghigo E, Ho K, Melmed S (2010) A consensus on criteria for cure of acromegaly. J Clin Endocrinolo Metabol 95(7):3141–3148. https://doi.org/10.1210/jc.2009-2670CrossRef

58.

De Marinis L, Zuppi P, Valle D, Mancini A, Bianchi A, Lauriola L, Pasquini P, Anile C, Maira G, Giustina A (2002) A retrospective hormonal and immunohistochemical evaluation of 47 acromegalic patients: prognostic value of preoperative plasma prolactin. Horm Metab Res 34(3):137–143. https://doi.org/10.1055/s-2002-23197CrossRefPubMed

59.

De P, Rees DA, Davies N, John R, Neal J, Mills RG, Vafidis J, Davies JS, Scanlon MF (2003) Transsphenoidal surgery for acromegaly in wales: results based on stringent criteria of remission. J Clin Endocrinol Metabol 88(8):3567–3572. https://doi.org/10.1210/jc.2002-021822CrossRef

60.

Esposito V, Santoro A, Minniti G, Salvati M, Innocenzi G, Lanzetta G, Cantore G (2004) Transsphenoidal adenomectomy for GH-, PRL- and ACTH-secreting pituitary tumours: outcome analysis in a series of 125 patients. Neurol Sci 25(5):251–256. https://doi.org/10.1007/s10072-004-0351-zCrossRefPubMed

61.

Fusco A, Zatelli MC, Bianchi A, Cimino V, Tilaro L, Veltri F, Angelini F, Lauriola L, Vellone V, Doglietto F, Ambrosio MR, Maira G, Giustina A, degli Uberti EC, Pontecorvi A, De Marinis L (2008) Prognostic significance of the Ki-67 labeling index in growth hormone-secreting pituitary adenomas. J Clin Endocrinol Metabol 93(7):2746–2750. https://doi.org/10.1210/jc.2008-0126CrossRef

62.

Kim MS, Jang HD, Kim OL (2009) Surgical results of growth hormone-secreting pituitary adenoma. J Korean Neurosurg Soc 45(5):271–274. https://doi.org/10.3340/jkns.2009.45.5.271CrossRefPubMedPubMedCentral

63.

Gondim JA, Almeida JP, de Albuquerque LA, Gomes E, Schops M, Ferraz T (2010) Pure endoscopic transsphenoidal surgery for treatment of acromegaly: results of 67 cases treated in a pituitary center. Neurosurg Focus 29(4):E7. https://doi.org/10.3171/2010.7.FOCUS10167CrossRefPubMed

64.

Krzentowska-Korek A, Golkowski F, Baldys-Waligorska A, Hubalewska-Dydejczyk A (2011) Efficacy and complications of neurosurgical treatment of acromegaly. Pituitary 14(2):157–162. https://doi.org/10.1007/s11102-010-0273-0CrossRefPubMed

65.

Dusek T, Kastelan D, Melada A, Baretic M, Skoric Polovina T, Perkovic Z, Giljevic Z, Jelcic J, Paladino J, Aganovic I, Korsic M (2011) Clinical features and therapeutic outcomes of patients with acromegaly: single-center experience. J Endocrinol Invest 34(11):e382–385. https://doi.org/10.3275/7858CrossRefPubMed

66.

Anthony JR, Alwahab UA, Kanakiya NK, Pontell DM, Veledar E, Oyesiku NM, Ioachimescu AG (2015) Significant elevation of growth hormone level impacts surgical outcomes in acromegaly. Endocr Pract 21(9):1001–1009. https://doi.org/10.4158/EP14587.ORCrossRefPubMed

67.

Buliman A, Tataranu LG, Ciubotaru V, Cazac TL, Dumitrache C (2016) The multimodal management of GH-secreting pituitary adenomas: predictive factors, strategies and outcomes. J Med Life 9(2):187–192PubMedPubMedCentral

68.

Jane JA Jr, Starke RM, Elzoghby MA, Reames DL, Payne SC, Thorner MO, Marshall JC, Laws ER Jr, Vance ML (2011) Endoscopic transsphenoidal surgery for acromegaly: remission using modern criteria, complications, and predictors of outcome. J Clin Endocrinol Metabol 96(9):2732–2740. https://doi.org/10.1210/jc.2011-0554CrossRef

69.

Sarkar S, Rajaratnam S, Chacko G, Chacko AG (2014) Endocrinological outcomes following endoscopic and microscopic transsphenoidal surgery in 113 patients with acromegaly. Clin Neurol Neurosurg 126:190–195. https://doi.org/10.1016/j.clineuro.2014.09.004CrossRefPubMed

70.

Sun H, Brzana J, Yedinak CG, Gultekin SH, Delashaw JB, Fleseriu M (2014) Factors associated with biochemical remission after microscopic transsphenoidal surgery for acromegaly. J Neurol Surg. Part B, Skull base 75(1):47–52. https://doi.org/10.1055/s-0033-1354578CrossRef

71.

Yildirim AE, Sahinoglu M, Divanlioglu D, Alagoz F, Gurcay AG, Daglioglu E, Okay HO, Belen AD (2014) Endoscopic endonasal transsphenoidal treatment for acromegaly: 2010 consensus criteria for remission and predictors of outcomes. Turk Neurosurg 24(6):906–912. https://doi.org/10.5137/1019-5149.JTN.11288-14.1CrossRefPubMed

72.

Fathalla H, Cusimano MD, Di Ieva A, Lee J, Alsharif O, Goguen J, Zhang S, Smyth H. (2015). Endoscopic versus microscopic approach for surgical treatment of acromegaly. Neurosurg Rev, 38(3): 541–548, discussion 548–549, 10.1007/s10143–015–0613–7

73.

Wang Q, Guo X, Gao L, Wang Z, Deng K, Lian W, Wang R, Zhu H, Xing B (2017) Surgical outcome of growth hormone-secreting pituitary adenoma with empty sella using a new classification. World Neurosurg 105:651–658. https://doi.org/10.1016/j.wneu.2017.06.071CrossRefPubMed

74.

Leopoldo C, Leopoldo F, Santos A, Veiga JCE, Lima JVJ, Scalissi NM, Lazarini PR, Dolci RLL (2017) Long term follow-up of growth hormone-secreting pituitary adenomas submitted to endoscopic endonasal surgery. Arq Neuropsiquiatr 75(5):301–306. https://doi.org/10.1590/0004-282X20170035CrossRefPubMed

75.

Almeida JP, Ruiz-Trevino AS, Liang B, Omay SB, Shetty SR, Chen YN, Anand VK, Grover K, Christos P, Schwartz TH (2018) Reoperation for growth hormone-secreting pituitary adenomas: report on an endonasal endoscopic series with a systematic review and meta-analysis of the literature. J Neurosurg 129(2):404–416. https://doi.org/10.3171/2017.2.JNS162673CrossRefPubMed

76.

Shimon I, Cohen ZR, Ram Z, Hadani M. (2001). Transsphenoidal surgery for acromegaly: endocrinological follow-up of 98 patients. Neurosurgery, 48(6): 1239–1243, discussion 1244–1235

77.

Antunes X, Ventura N, Camilo GB, Wildemberg LE, Guasti A, Pereira PJM, Camacho AHS, Chimelli L, Niemeyer P, Gadelha MR, Kasuki L (2018) Predictors of surgical outcome and early criteria of remission in acromegaly. Endocrine 60(3):415–422. https://doi.org/10.1007/s12020-018-1590-8CrossRefPubMed

78.

Osman IA, James RA, Chatterjee S, Mathias D, Kendall-Taylor P (1994) Factors determining the long-term outcome of surgery for acromegaly. QJM 87(10):617–623PubMed

79.

Kaltsas GA, Isidori AM, Florakis D, Trainer PJ, Camacho-Hubner C, Afshar F, Sabin I, Jenkins JP, Chew SL, Monson JP, Besser GM, Grossman AB (2001) Predictors of the outcome of surgical treatment in acromegaly and the value of the mean growth hormone day curve in assessing postoperative disease activity. J Clin Endocrinol Metabol 86(4):1645–1652. https://doi.org/10.1210/jcem.86.4.7398CrossRef

80.

Biermasz NR, van Dulken H, Roelfsema F (2000) Ten-year follow-up results of transsphenoidal microsurgery in acromegaly. J Clin Endocrinol Metabol 85(12):4596–4602. https://doi.org/10.1210/jcem.85.12.7042CrossRef

81.

Trepp R, Stettler C, Zwahlen M, Seiler R, Diem P, Christ ER. (2005). Treatment outcomes and mortality of 94 patients with acromegaly. Acta neurochirurgica, 147(3): 243–251; discussion 250–241, 10.1007/s00701–004–0466–2

82.

Asha, M.J., Takami, H., Velasquez, C., Oswari, S., Almeida, J.P., Zadeh, G., Gentili, F.: Long-term outcomes of transsphenoidal surgery for management of growth hormone-secreting adenomas: single-center results. Journal of neurosurgery, 1–11 (2019). doi:10.3171/2019.6.JNS191187

83.

Bourdelot A, Coste J, Hazebroucq V, Gaillard S, Cazabat L, Bertagna X, Bertherat J (2004) Clinical, hormonal and magnetic resonance imaging (MRI) predictors of transsphenoidal surgery outcome in acromegaly. Eur J Endocrinol 150(6):763–771CrossRef

84.

Kreutzer J, Vance ML, Lopes MB, Laws ER Jr (2001) Surgical management of GH-secreting pituitary adenomas: an outcome study using modern remission criteria. J Clin Endocrinol Metabol. https://doi.org/10.1210/jcem.86.9.7819CrossRef

85.

Rotermund R, Burkhardt T, Rohani Z, Jung R, Aberle J, Flitsch J (2018) Value of early postoperative random growth hormone levels and nadir growth hormone levels after oral glucose tolerance testing in acromegaly. Growth Hormone & IGF Res 41:64–70. https://doi.org/10.1016/j.ghir.2018.03.002CrossRef

86.

Sarkar S, Chacko AG, Chacko G. (2014). An analysis of granulation patterns, MIB-1 proliferation indices and p53 expression in 101 patients with acromegaly. Acta neurochirurgica, 156(12): 2221–2230, discussion 2230, 10.1007/s00701–014–2230–6

87.

Varadhan L, Reulen RC, Brown M, Clayton RN (2016) The role of cumulative growth hormone exposure in determining mortality and morbidity in acromegaly: a single centre study. Pituitary 19(3):251–261. https://doi.org/10.1007/s11102-015-0700-3CrossRefPubMed

88.

van der Lely AJ, Harris AG, Lamberts SW (1992) The sensitivity of growth hormone secretion to medical treatment in acromegalic patients: influence of age and sex. Clin Endocrinol 37(2):181–185CrossRef

89.

Colao A, Amato G, Pedroncelli AM, Baldelli R, Grottoli S, Gasco V, Petretta M, Carella C, Pagani G, Tambura G, Lombardi G (2002) Gender- and age-related differences in the endocrine parameters of acromegaly. J Endocrinol Invest 25(6):532–538CrossRef

90.

Petersenn S, Buchfelder M, Gerbert B, Franz H, Quabbe HJ, Schulte HM, Grussendorf M, Reincke M, Participants of the German acromegaly, R. (2009). Age and sex as predictors of biochemical activity in acromegaly: analysis of 1485 patients from the German Acromegaly Register. Clin Endocrinol, 71(3): 400–405, 10.1111/j.1365–2265.2009.03547.x

91.

Ioachimescu AG, Handa T, Goswami N, Pappy AL 2nd, Veledar E, Oyesiku NM (2019) Gender differences and temporal trends over two decades in acromegaly: a single center study in 112 patients. Endocrine. https://doi.org/10.1007/s12020-019-02123-4CrossRefPubMed

92.

Kreitschmann-Andermahr I, Siegel S, Kleist B, Kohlmann J, Starz D, Buslei R, Koltowska-Haggstrom M, Strasburger CJ, Buchfelder M (2016) Diagnosis and management of acromegaly: the patient's perspective. Pituitary 19(3):268–276. https://doi.org/10.1007/s11102-015-0702-1CrossRefPubMed

93.

Barkan AL, Beitins IZ, Kelch RP (1988) Plasma insulin-like growth factor-I/somatomedin-C in acromegaly: correlation with the degree of growth hormone hypersecretion. J Clin Endocrinol Metabol 67(1):69–73. https://doi.org/10.1210/jcem-67-1-69CrossRef

94.

Ho KY, Weissberger AJ (1994) Characterization of 24-hour growth hormone secretion in acromegaly: implications for diagnosis and therapy. Clin Endocrinol 41(1):75–83CrossRef

95.

Parkinson C, Renehan AG, Ryder WD, O'Dwyer ST, Shalet SM, Trainer PJ (2002) Gender and age influence the relationship between serum GH and IGF-I in patients with acromegaly. Clin Endocrinol 57(1):59–64CrossRef

96.

Gadelha MR (2015) A paradigm shift in the medical treatment of acromegaly: from a 'trial and error' to a personalized therapeutic decision-making process. Clin Endocrinol 83(1):1–2. https://doi.org/10.1111/cen.12797CrossRef

97.

Pappy AL 2nd, Savinkina A, Bicknese C, Neill S, Oyesiku NM, Ioachimescu AG (2019) Predictive modeling for pituitary adenomas: single center experience in 501 consecutive patients. Pituitary 22(5):520–531. https://doi.org/10.1007/s11102-019-00982-8CrossRefPubMed

98.

Trouillas J, Roy P, Sturm N, Dantony E, Cortet-Rudelli C, Viennet G, Bonneville JF, Assaker R, Auger C, Brue T, Cornelius A, Dufour H, Jouanneau E, Francois P, Galland F, Mougel F, Chapuis F, Villeneuve L, Maurage CA, Figarella-Branger D, Raverot G, members of H, Barlier A, Bernier M, Bonnet F, Borson-Chazot F, Brassier G, Caulet-Maugendre S, Chabre O, Chanson P, Cottier JF, Delemer B, Delgrange E, Di Tommaso L, Eimer S, Gaillard S, Jan M, Girard JJ, Lapras V, Loiseau H, Passagia JG, Patey M, Penfornis A, Poirier JY, Perrin G, Tabarin A. (2013). A new prognostic clinicopathological classification of pituitary adenomas: a multicentric case-control study of 410 patients with 8 years post-operative follow-up. Acta Neuropathol, 126(1): 123–135, 10.1007/s00401–013–1084-y

99.

Casanueva FF, Barkan AL, Buchfelder M, Klibanski A, Laws ER, Loeffler JS, Melmed S, Mortini P, Wass J, Giustina A (2017) Criteria for the definition of pituitary tumor centers of excellence (PTCOE): a pituitary society statement. Pituitary 20(5):489–498. https://doi.org/10.1007/s11102-017-0838-2CrossRefPubMedPubMedCentral

100.

Ghajar A, Jones PS, Guarda FJ, Faje A, Tritos NA, Miller KK, Swearingen B, Nachtigall LB (2020) Biochemical control in acromegaly with multimodality therapies: outcomes from a pituitary center and changes over time. J Clin Endocrinol Metabol. https://doi.org/10.1210/clinem/dgz187CrossRef

101.

Espinosa-de-los-Monteros AL, Mercado M, Sosa E, Lizama O, Guinto G, Lopez-Felix B, Garcia O, Hernandez I, Ovalle A, Mendoza V (2002) Changing patterns of insulin-like growth factor-I and glucose-suppressed growth hormone levels after pituitary surgery in patients with acromegaly. J Neurosurg 97(2):287–292. https://doi.org/10.3171/jns.2002.97.2.0287CrossRefPubMed

102.

Alexopoulou O, Bex M, Abs R, T'Sjoen G, Velkeniers B, Maiter D (2008) Divergence between growth hormone and insulin-like growth factor-i concentrations in the follow-up of acromegaly. J Clin Endocrinol Metabol 93(4):1324–1330. https://doi.org/10.1210/jc.2007-2104CrossRef

103.

Zeinalizadeh M, Habibi Z, Fernandez-Miranda JC, Gardner PA, Hodak SP, Challinor SM (2015) Discordance between growth hormone and insulin-like growth factor-1 after pituitary surgery for acromegaly: a stepwise approach and management. Pituitary 18(1):48–59. https://doi.org/10.1007/s11102-014-0556-yCrossRefPubMed

Titel: Prognostic factors of biochemical remission after transsphenoidal surgery for acromegaly: a structured review
verfasst von: Nidhi Agrawal
Adriana G. Ioachimescu
Publikationsdatum: 29.06.2020
Verlag: Springer US
Schlagwörter: Surgery
Acromegaly
Erschienen in: Pituitary / Ausgabe 5/2020
Print ISSN: 1386-341X
Elektronische ISSN: 1573-7403
DOI: https://doi.org/10.1007/s11102-020-01063-x

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Prognostic factors of biochemical remission after transsphenoidal surgery for acromegaly: a structured review

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