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Prevention Science

Erschienen in:

21.09.2016

Prevention of Early Substance Use Mediates, and Variation at SLC6A4 Moderates, SAAF Intervention Effects on OXTR Methylation

verfasst von: Steven R. H. Beach, Man Kit Lei, Gene H. Brody, Robert A. Philibert

Erschienen in: Prevention Science | Ausgabe 1/2018

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Abstract

The Strong African American Family (SAAF) program has been shown to have a variety of short and long-term benefits for participating youth and families. However, biological mechanisms potentially influencing long-term effects on resilience in young adulthood have not been examined. In the current investigation, we examine the effects of SAAF on methylation of the OXTR gene in young adulthood, focusing on a regulatory region previously identified to be both responsive to stress and implicated in resilience. Using the subsample of participants from the original study for whom methylation data was available (N = 388), we replicated the previously reported G × E effect on prevention of early substance use and then examined whether there would also be a moderated effect on OXTR methylation in early adulthood, with “s” allele carriers, but not “LL” participants, showing a significant indirect effect of SAAF on OXTR methylation. Results suggest that for susceptible youth (i.e., “s” allele carriers), preventive intervention may “get under the skin,” in a manner potentially beneficial for long-term outcomes. Implications for examination of OXTR methylation in future prevention research are discussed.

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Titel: Prevention of Early Substance Use Mediates, and Variation at SLC6A4 Moderates, SAAF Intervention Effects on OXTR Methylation
verfasst von: Steven R. H. Beach
Man Kit Lei
Gene H. Brody
Robert A. Philibert
Publikationsdatum: 21.09.2016
Verlag: Springer US
Erschienen in: Prevention Science / Ausgabe 1/2018
Print ISSN: 1389-4986
Elektronische ISSN: 1573-6695
DOI: https://doi.org/10.1007/s11121-016-0709-5

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Prevention of Early Substance Use Mediates, and Variation at SLC6A4 Moderates, SAAF Intervention Effects on OXTR Methylation

Abstract

Live-Webinar: Aktuelle Leitlinien bei Herz-Kreislauf-Erkrankungen

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