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Responsiveness of the EQ-5D and 8-item Parkinson’s Disease Questionnaire (PDQ-8) in a 4-year follow-up study

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Abstract

Objective

The purpose of this study was to evaluate the responsiveness of the EQ-5D and the Parkinson’s Disease Questionnaire (PDQ-8) to deterioration in health-related quality of life (HRQoL) in patients with Parkinson’s disease (PD).

Methods

HRQoL and clinical data collected from 31 patients with PD (male: 74.2%, mean age: 61 years) who were surveyed with the EQ-5D and the PDQ-8 questionnaires in 2002 and 2006/2007 were analyzed. Responsiveness of the EQ-5D, PDQ-8, and Hoehn and Yahr (H&Y) staging were assessed according to Cohen’s effect size (ES) and standardized response mean (SRM).

Results

The mean (standard deviation) EQ-5D index and PDQ-8 summary index (PDQ-8SI) scores were 0.76 (0.23) and 17.7 (14.2) at baseline and 0.52 (0.33) and 35.1 (17.4) at year four. Based on both ES and SRM indices, the rank order of responsiveness of the studied measures, from high to low, was PDQ-8SI (ES = 1.22), EQ-5D index score (ES = 1.06), H&Y score (ES = 0.82), and the EQ-VAS score (ES = 0.24).

Conclusion

Both the EQ-5D and PDQ-8 are responsive to changes in health burden of the Parkinson’s disease over a 4-year period.

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Abbreviations

HRQoL:

Health-related quality of life

PD:

Parkinson’s disease

PDQ:

Parkinson’s Disease Questionnaire

VAS:

Visual analog scale

References

  1. Gold, M. R., Patrick, D. L., Torrance, D. G., et al. (1996). Identifying and valuing outcomes. In M. R. Gold (Ed.), Cost-effectiveness in health and medicine (pp. 82–134). New York, NY: Oxford University Pres.

    Google Scholar 

  2. Drummond, M. F., O’ Brien, B. J., & Stoddart, G. L. (1997). Cost-utility analysis. In: Methods for the economic evaluation of health care programmes (2nd ed.). Oxford: Oxford University Press, pp 139–199.

  3. Schrag, A., Selai, C., Jahanshahi, M., & Quinn, N. P. (2000). The EQ-5D–a generic quality of life measure-is a useful instrument to measure quality of life in patients with Parkinson’s disease. Journal of Neurology, Neurosurgery and Psychiatry, 69, 67–73.

    Article  CAS  Google Scholar 

  4. Luo, N., Low, S., Lau, P. N., Au, W. L., & Tan, L. C. S. (2009). Is EQ-5D a valid quality of life instrument in patients with Parkinson’s disease? A study in Singapore. Annals of the Academy of Medicine, Singapore, 38, 521–528.

    PubMed  Google Scholar 

  5. Reuther, M., Spottke, E. A., & Klotsche, J. (2007). Assessing health-related quality of life in patients with Parkinson’s disease in a prospective longitudinal study. Parkinsonism & Related Disorders, 13, 108–114.

    Article  CAS  Google Scholar 

  6. Noyes, K., Dick, A. W., Holloway, R. G., & Parkinson Study Group. (2006). Pramipexole versus levodopa in patients with early Parkinson’s disease: Effect on generic and disease-specific quality of life. Value Health, 9, 28–38.

    Article  PubMed  Google Scholar 

  7. Schrag, A., Spottke, A., Quinn, N. P., & Dodel, R. (2009). Comparative responsiveness of Parkinson’s disease scales to change over time. Movement Disorders, 24, 813–818.

    Article  PubMed  Google Scholar 

  8. Noyes, K., Dick, A. W., Holloway, R. G., & Group, Parkinson. Study. (2004). Pramipexole v. levodopa as initial treatment for Parkinson’s disease: A randomized clinical-economic trial. Medical Decision Making, 24, 472–485.

    Article  PubMed  Google Scholar 

  9. Reichmann, H., Boas, J., Macmahon, D., Myllyla, V., Hakala, A., Reinikainen, K., et al. (2005). Efficacy of combining levodopa with entacapone on quality of life and activities of daily living in patients experiencing wearing-off type fluctuations. Acta Neurologica Scandinavica, 111, 21–28.

    Article  CAS  PubMed  Google Scholar 

  10. Karlsen, K. H., Tandberg, E., Arsland, D., & Larsen, J. P. (2000). Health related quality of life in Parkinson’s disease: A prospective longitudinal study. Journal of Neurology, Neurosurgery and Psychiatry, 69, 584–589.

    Article  CAS  Google Scholar 

  11. Jenkinson, C., Fitzpatrick, R., Peto, V., Greenhall, R., & Hyman, N. (1997). The PDQ-8: Development and validation of a short-form Parkinson’s disease questionnaire. Psychology Health, 12, 805–814.

    Article  Google Scholar 

  12. Tan, L. C. S., Luo, N., Nazri, M., Li, S. C., & Thumboo, J. (2004). Validity and reliability of the PDQ-39 and PDQ-8 in English-speaking patients in Singapore. Parkinsonism & Related Disorders, 10, 493–499.

    Article  Google Scholar 

  13. Tan, L. C., Lau, P. N., Au, W. L., & Luo, N. (2007). Validation of PDQ-8 as an independent instrument in English and Chinese. Journal of the Neurological Sciences, 255, 77–80.

    Article  PubMed  Google Scholar 

  14. Gelb, D. J., Oliver, E., & Gilman, S. (1999). Diagnostic criteria for Parkinson disease. Archives of Neurology, 56, 33–39.

    Article  CAS  PubMed  Google Scholar 

  15. Fahn, S., Marsden, C. D., Calne, D. B., & Goldstein, M. (Eds.). (1987). Recent developments in Parkinson’s Disease (Vol. 2, pp. 153–163). Florham Park, NJ: Macmillan Health Care Information.

    Google Scholar 

  16. Peto, V., Jenkinson, C., & Fitzpatrick, R. (1998). PDQ-39: A review of the development, validation and application of a Parkinson’s disease quality of life questionnaire and its associated measures. Journal of Neurology, 245(suppl 1), S10–S14.

    Article  PubMed  Google Scholar 

  17. Dolan, P. (1997). Modeling valuations for EuroQol health states. Medical Care, 35, 1095–1108.

    Article  CAS  PubMed  Google Scholar 

  18. Fayers, P. M., & Machin, D. (2000). Quality of life: Assessment analysis and interpretation. Chichester: Wiley.

    Google Scholar 

  19. Cohen, J. (1998). Statistical power analysis for the behavioral sciences (2nd ed.). Hillsdale: Lawrence Earlbaum Associates.

    Google Scholar 

  20. Luo, N., Tan, L. C., Zhao, Y., Lau, P. N., Au, W. L., Li, S. C., et al. (2009). Determination of the longitudinal validity and minimally important difference of the 8-item Parkinson’s Disease Questionnaire (PDQ-8). Movement Disorders, 24, 183–187.

    Article  PubMed  Google Scholar 

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Correspondence to Nan Luo.

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Luo, N., Ng, WY., Lau, PN. et al. Responsiveness of the EQ-5D and 8-item Parkinson’s Disease Questionnaire (PDQ-8) in a 4-year follow-up study. Qual Life Res 19, 565–569 (2010). https://doi.org/10.1007/s11136-010-9615-7

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