Skip to main content
Erschienen in: Quality of Life Research 3/2012

01.04.2012

Palliative care outcomes in surgical oncology patients with advanced malignancies: a mixed methods approach

verfasst von: Gwenyth R. Wallen, Karen Baker, Marilyn Stolar, Claiborne Miller-Davis, Nancy Ames, Jan Yates, Jacques Bolle, Donna Pereira, Diane St. Germain, Daniel Handel, Ann Berger

Erschienen in: Quality of Life Research | Ausgabe 3/2012

Einloggen, um Zugang zu erhalten

Abstract

Purpose

To prospectively compare outcomes and processes of hospital-based early palliative care with standard care in surgical oncology patients (N = 152).

Methods

A randomized, mixed methods, longitudinal study evaluated the effectiveness of a hospital-based Pain and Palliative Care Service (PPCS). Interviews were conducted presurgically and at follow-up visits up to 1 year. Primary outcome measures included the Gracely Pain Intensity and Unpleasantness Scales and the Symptom Distress Scale. Qualitative interviews assessed social support, satisfaction with care, and communication with providers. Survival analysis methods explored factors related to treatment crossover and study discontinuation. Models for repeated measures within subjects over time explored treatment and covariate effects on patient-reported pain and symptom distress.

Results

None of the estimated differences achieved statistical significance; however, for those who remained on study for 12 months, the PPCS group performed better than their standard of care counterparts. Patients identified consistent communication, emotional support, and pain and symptom management as positive contributions delivered by the PPCS.

Conclusions

It is unclear whether lower pain perceptions despite greater symptom distress were clinically meaningful; however, when coupled with the patients’ perceptions of their increased resources and alternatives for pain control, one begins to see the value of an integrated PPCS.
Literatur
1.
Zurück zum Zitat Arnold, B. L. (2011). Mapping hospice patients” perception and verbal communication of end-of-life needs: An exploratory mixed methods inquiry. BMC Palliative Care, 10(1), 1–10.PubMedCrossRef Arnold, B. L. (2011). Mapping hospice patients” perception and verbal communication of end-of-life needs: An exploratory mixed methods inquiry. BMC Palliative Care, 10(1), 1–10.PubMedCrossRef
2.
Zurück zum Zitat Bakitas, M., Lyons, K. D., Hegel, M. T., Balan, S., Brokaw, F. C., Seville, J., et al. (2009). Effects of a palliative care intervention on clinical outcomes in patients with advanced cancer: The project ENABLE II randomized controlled trial. Journal of the American Medical Association, 302(7), 741–749.PubMedCrossRef Bakitas, M., Lyons, K. D., Hegel, M. T., Balan, S., Brokaw, F. C., Seville, J., et al. (2009). Effects of a palliative care intervention on clinical outcomes in patients with advanced cancer: The project ENABLE II randomized controlled trial. Journal of the American Medical Association, 302(7), 741–749.PubMedCrossRef
3.
Zurück zum Zitat Barrera, M. (1986). Distinctions between social support concepts, measures, and models. American Journal of Community Psychology, 14(4), 413–445.CrossRef Barrera, M. (1986). Distinctions between social support concepts, measures, and models. American Journal of Community Psychology, 14(4), 413–445.CrossRef
4.
Zurück zum Zitat Carr, A. J., & Higginson, I. J. (2001). Measuring quality of life: Are quality of life measures patient centered? British Medical Journal, 322, 1357–1360.PubMedCrossRef Carr, A. J., & Higginson, I. J. (2001). Measuring quality of life: Are quality of life measures patient centered? British Medical Journal, 322, 1357–1360.PubMedCrossRef
5.
Zurück zum Zitat Cleeland, C. S. (2001). Cross-cutting research issues: A research agenda for reducing distress of patients with cancer. In K. M. Foley & H. Gellband (Eds.), Improving palliative care for cancer (pp. 233–276). Washington, DC: National Academy Press. Cleeland, C. S. (2001). Cross-cutting research issues: A research agenda for reducing distress of patients with cancer. In K. M. Foley & H. Gellband (Eds.), Improving palliative care for cancer (pp. 233–276). Washington, DC: National Academy Press.
6.
Zurück zum Zitat Creswell, J. W. (2009). Research design: Qualitative, quantitative, and mixed methods (3rd ed). Thousand Oaks, CA: Sage. Creswell, J. W. (2009). Research design: Qualitative, quantitative, and mixed methods (3rd ed). Thousand Oaks, CA: Sage.
7.
Zurück zum Zitat Creswell, J. W., & Plano Clark, V. L. (2007). Designing and conducting mixed methods research. Thousand Oaks, CA: Sage. Creswell, J. W., & Plano Clark, V. L. (2007). Designing and conducting mixed methods research. Thousand Oaks, CA: Sage.
8.
Zurück zum Zitat Creswell, J. W., & Zhang, W. (2009). The application of mixed methods designs to trauma research. Journal of Traumatic Stress, 22(6), 612–621. Creswell, J. W., & Zhang, W. (2009). The application of mixed methods designs to trauma research. Journal of Traumatic Stress, 22(6), 612–621.
9.
Zurück zum Zitat Del Bufalo, C., Morelli, A., Bassein, L., Fasano, L., Quarta, C. C., Pacilli, A. M., et al. (1995). Severity scores in respiratory intensive care: Apache ii predicted mortality better than saps ii. Respiratory Care, 40(10), 1042–1047.PubMed Del Bufalo, C., Morelli, A., Bassein, L., Fasano, L., Quarta, C. C., Pacilli, A. M., et al. (1995). Severity scores in respiratory intensive care: Apache ii predicted mortality better than saps ii. Respiratory Care, 40(10), 1042–1047.PubMed
10.
Zurück zum Zitat Devery, K., Lennie, I., & Cooney, N. (1999). Health outcomes for people who use palliative care services. Journal of Palliative Care, 15(2), 5–12.PubMed Devery, K., Lennie, I., & Cooney, N. (1999). Health outcomes for people who use palliative care services. Journal of Palliative Care, 15(2), 5–12.PubMed
11.
Zurück zum Zitat Gracely, R. H., Dubner, R., & McGrath, P. A. (1982). Fentanyl reduces the intensity of painful tooth pulp sensations: Controlling for detection of active drugs. Anesthesia and Analgesia, 61(9), 751–755.PubMedCrossRef Gracely, R. H., Dubner, R., & McGrath, P. A. (1982). Fentanyl reduces the intensity of painful tooth pulp sensations: Controlling for detection of active drugs. Anesthesia and Analgesia, 61(9), 751–755.PubMedCrossRef
12.
Zurück zum Zitat Gracely, R. H., & Kwilosz, D. M. (1988). The descriptor differential scale: Applying psychophysical principles to clinical pain assessment. Pain, 35(3), 279–288.PubMedCrossRef Gracely, R. H., & Kwilosz, D. M. (1988). The descriptor differential scale: Applying psychophysical principles to clinical pain assessment. Pain, 35(3), 279–288.PubMedCrossRef
13.
Zurück zum Zitat Gracely, R. H., McGrath, P., & Dubner, R. (1978). Ratio scales of sensory and affective verbal pain descriptors. Pain, 5(1), 5–18.PubMedCrossRef Gracely, R. H., McGrath, P., & Dubner, R. (1978). Ratio scales of sensory and affective verbal pain descriptors. Pain, 5(1), 5–18.PubMedCrossRef
14.
Zurück zum Zitat Grande, G., & Todd, C. J. (2000). Why are trials in palliative care so difficult? Palliative Medicine, 14(1), 69–74.PubMedCrossRef Grande, G., & Todd, C. J. (2000). Why are trials in palliative care so difficult? Palliative Medicine, 14(1), 69–74.PubMedCrossRef
15.
Zurück zum Zitat Helgeson, V. S., & Cohen, S. (1996). Social support and adjustment to cancer: Reconciling descriptive, correlational, and intervention research. Health Psychology, 15(2), 135–148.PubMedCrossRef Helgeson, V. S., & Cohen, S. (1996). Social support and adjustment to cancer: Reconciling descriptive, correlational, and intervention research. Health Psychology, 15(2), 135–148.PubMedCrossRef
16.
Zurück zum Zitat Higginson, I. J. (1999). Evidence based palliative care. There is some evidence-and there needs to be more. BMJ, 319(7208), 462–463.PubMedCrossRef Higginson, I. J. (1999). Evidence based palliative care. There is some evidence-and there needs to be more. BMJ, 319(7208), 462–463.PubMedCrossRef
17.
Zurück zum Zitat Higginson, I. J., & Carr, A. J. (2001). Measuring quality of life: Using quality of life measures in the clinical setting. BMJ, 322(7297), 1297–1300.PubMedCrossRef Higginson, I. J., & Carr, A. J. (2001). Measuring quality of life: Using quality of life measures in the clinical setting. BMJ, 322(7297), 1297–1300.PubMedCrossRef
18.
Zurück zum Zitat Higginson, I. J., Finlay, I., Goodwin, D. M., Cook, A. M., Hood, K., Edwards, A. G., et al. (2002). Do hospital-based palliative teams improve care for patients or families at the end of life? Journal of Pain and Symptom Management, 23(2), 96–106. Higginson, I. J., Finlay, I., Goodwin, D. M., Cook, A. M., Hood, K., Edwards, A. G., et al. (2002). Do hospital-based palliative teams improve care for patients or families at the end of life? Journal of Pain and Symptom Management, 23(2), 96–106.
19.
Zurück zum Zitat Hutchison, C. (1999). Social support: Factors to consider when designing studies that measure social support. Journal of Advanced Nursing, 29(6), 1520–1526.PubMedCrossRef Hutchison, C. (1999). Social support: Factors to consider when designing studies that measure social support. Journal of Advanced Nursing, 29(6), 1520–1526.PubMedCrossRef
20.
Zurück zum Zitat Israel, B. A., & Schurman, S. J. (1990). Social support, control and the stress process. In K. Glanz, B. K. Rimer, & F. M. Lewis (Eds.), Health behavior and health education: Theory, research, and practice. San Francisco: Jossey-Bass. Israel, B. A., & Schurman, S. J. (1990). Social support, control and the stress process. In K. Glanz, B. K. Rimer, & F. M. Lewis (Eds.), Health behavior and health education: Theory, research, and practice. San Francisco: Jossey-Bass.
21.
Zurück zum Zitat Jackson, B. S., Strauman, J., Frederickson, K., & Strauman, T. J. (1991). Long-term biopsychosocial effects of interleukin-2 therapy. Oncology Nursing Forum, 18, 683–690.PubMed Jackson, B. S., Strauman, J., Frederickson, K., & Strauman, T. J. (1991). Long-term biopsychosocial effects of interleukin-2 therapy. Oncology Nursing Forum, 18, 683–690.PubMed
22.
Zurück zum Zitat Karim, K. (2000). Conducting research involving palliative patients. Nursing Standard, 15(2), 34–36. Karim, K. (2000). Conducting research involving palliative patients. Nursing Standard, 15(2), 34–36.
23.
Zurück zum Zitat Knaus, W. A., Draper, E. A., Wagner, D. P., & Zimmerman, J. E. (1985). APACHE II: A severity of disease classification system. Critical Care Medicine, 13(10), 818–829.PubMedCrossRef Knaus, W. A., Draper, E. A., Wagner, D. P., & Zimmerman, J. E. (1985). APACHE II: A severity of disease classification system. Critical Care Medicine, 13(10), 818–829.PubMedCrossRef
24.
Zurück zum Zitat Krueger, R. A. (1998). Analyzing & reporting focus groups. Thousand Oaks, CA: Sage Publications, Inc. Krueger, R. A. (1998). Analyzing & reporting focus groups. Thousand Oaks, CA: Sage Publications, Inc.
25.
Zurück zum Zitat Lesage, P., & Portenoy, R. K. (2001). Ethical challenges in the care of patients with serious illness. Pain Medicine, 2(2), 121–130.PubMedCrossRef Lesage, P., & Portenoy, R. K. (2001). Ethical challenges in the care of patients with serious illness. Pain Medicine, 2(2), 121–130.PubMedCrossRef
26.
Zurück zum Zitat Max, M. B., Lynch, S. A., Muir, J., Shoaf, S. E., Smoller, B., & Dubner, R. (1992). Effects of desipramine, amitriptyline, and fluoxetine on pain in diabetic neuropathy. New England Journal of Medicine, 326(19), 1250–1256.PubMedCrossRef Max, M. B., Lynch, S. A., Muir, J., Shoaf, S. E., Smoller, B., & Dubner, R. (1992). Effects of desipramine, amitriptyline, and fluoxetine on pain in diabetic neuropathy. New England Journal of Medicine, 326(19), 1250–1256.PubMedCrossRef
27.
Zurück zum Zitat Mazzocato, C., Sweeney, C., & Bruera, E. (2001). Clinical research in palliative care: Patient populations, symptoms, interventions and endpoints. Palliative Medicine, 15(2), 163–168.PubMedCrossRef Mazzocato, C., Sweeney, C., & Bruera, E. (2001). Clinical research in palliative care: Patient populations, symptoms, interventions and endpoints. Palliative Medicine, 15(2), 163–168.PubMedCrossRef
28.
Zurück zum Zitat McArthur, J. C., Yiannoutsos, C., Simpson, D. M., Adornato, B. T., Singer, E. J., Hollander, H., et al. (2000). A phase II trial of nerve growth factor for sensory neuropathy associated with hiv infection. Neurology, 54(5), 1080–1088. McArthur, J. C., Yiannoutsos, C., Simpson, D. M., Adornato, B. T., Singer, E. J., Hollander, H., et al. (2000). A phase II trial of nerve growth factor for sensory neuropathy associated with hiv infection. Neurology, 54(5), 1080–1088.
29.
Zurück zum Zitat McCorkle, R., Cooley, M. E., & Shea, J. A. (1998). A user’s manual for the symptom distress scale. Philadelphia: University of Pennsylvania. McCorkle, R., Cooley, M. E., & Shea, J. A. (1998). A user’s manual for the symptom distress scale. Philadelphia: University of Pennsylvania.
31.
Zurück zum Zitat Morgan, D. L. (1998). Computerized analysis. In R. A. Krueger (Ed.), Analyzing & reporting focus groups. Thousand Oaks, CA: Sage Publications, Inc. Morgan, D. L. (1998). Computerized analysis. In R. A. Krueger (Ed.), Analyzing & reporting focus groups. Thousand Oaks, CA: Sage Publications, Inc.
32.
Zurück zum Zitat O’Mara, A. M., Germain, D., Ferrell, B., & Bornemann, T. (2009). Challenges to and lessons learned from conducting palliative care research. Journal of Pain and Symptom Management, 37(3), 387–394.PubMedCrossRef O’Mara, A. M., Germain, D., Ferrell, B., & Bornemann, T. (2009). Challenges to and lessons learned from conducting palliative care research. Journal of Pain and Symptom Management, 37(3), 387–394.PubMedCrossRef
33.
Zurück zum Zitat Portenoy, R. K., Thaler, H. T., Kornblith, A. B., McCarthy L. J., Friedlander-Klar, H., Kiyasu, E., et al. (1994). The memorial symptom assessment scale: An instrument for the evaluation of symptom prevalence, characteristics and distress. European Journal of Cancer Part A: General Topics, 30(9), 1326–1336. Portenoy, R. K., Thaler, H. T., Kornblith, A. B., McCarthy L. J., Friedlander-Klar, H., Kiyasu, E., et al. (1994). The memorial symptom assessment scale: An instrument for the evaluation of symptom prevalence, characteristics and distress. European Journal of Cancer Part A: General Topics, 30(9), 1326–1336.
34.
Zurück zum Zitat Radloff, L. S. (1977). The CES-D scale: A self-report depression scale for research in the general population. Applied Psychological Measurement, 1(3), 385–401.CrossRef Radloff, L. S. (1977). The CES-D scale: A self-report depression scale for research in the general population. Applied Psychological Measurement, 1(3), 385–401.CrossRef
35.
Zurück zum Zitat Sarna, L. (1998). Effectiveness of structured nursing assessment of symptom distress in advanced lung cancer. Oncology Nursing Forum, 25, 1041–1048.PubMed Sarna, L. (1998). Effectiveness of structured nursing assessment of symptom distress in advanced lung cancer. Oncology Nursing Forum, 25, 1041–1048.PubMed
36.
Zurück zum Zitat Sarna, L., Lindsey, A. M., Dean, H., Brecht, M. L., & McCorkle, R. (1993). Nutritional intake, weight change, symptom distress, and functional status over time in adults with lung cancer. Oncology Nursing Forum, 20, 481–489.PubMed Sarna, L., Lindsey, A. M., Dean, H., Brecht, M. L., & McCorkle, R. (1993). Nutritional intake, weight change, symptom distress, and functional status over time in adults with lung cancer. Oncology Nursing Forum, 20, 481–489.PubMed
37.
Zurück zum Zitat Shaver, P. R., & Brennan, K. A. (1991). Measures of depression and loneliness. In J. P. Robinson, P. R. Shaver, & L. S. Wrightsman (Eds.), Measures of personality and social psychological attitudes. San Diego: Academic Press Inc. Shaver, P. R., & Brennan, K. A. (1991). Measures of depression and loneliness. In J. P. Robinson, P. R. Shaver, & L. S. Wrightsman (Eds.), Measures of personality and social psychological attitudes. San Diego: Academic Press Inc.
38.
Zurück zum Zitat Standing Medical Advisory Committee, & Committee, Standing Nursing and Midwifery Advisory. (1992). The principles and provision of palliative care. London. Standing Medical Advisory Committee, & Committee, Standing Nursing and Midwifery Advisory. (1992). The principles and provision of palliative care. London.
39.
Zurück zum Zitat Taylor, E. J. (1993). Factors associated with meaning in life among people with recurrent cancer. Onclology Nursing Forum, 20, 1399–1407. Taylor, E. J. (1993). Factors associated with meaning in life among people with recurrent cancer. Onclology Nursing Forum, 20, 1399–1407.
40.
Zurück zum Zitat Ternel, J. S., Greer, J. A., Musilkansky, M. A., Gallagher, E. R., Admane, S., Jackson, V. A., et al. (2010). Early palliative care for patients with metastatic non-small-cell lung cancer. The New England Journal of Medicine, 363, 733–742.CrossRef Ternel, J. S., Greer, J. A., Musilkansky, M. A., Gallagher, E. R., Admane, S., Jackson, V. A., et al. (2010). Early palliative care for patients with metastatic non-small-cell lung cancer. The New England Journal of Medicine, 363, 733–742.CrossRef
41.
Zurück zum Zitat Wallen, G. R., & Berger, A. (2004). Mixed methods: In search of truth in palliative care medicine. Journal of Palliative Medicine, 7(3), 403–404.PubMedCrossRef Wallen, G. R., & Berger, A. (2004). Mixed methods: In search of truth in palliative care medicine. Journal of Palliative Medicine, 7(3), 403–404.PubMedCrossRef
42.
Zurück zum Zitat Wallen, G. R., Ulrich, C., & Grady, C. (2005). Learning about a “Good Death”: Ethical considerations in palliative care nursing research. DNA Reporter, 30(2), 8–9. Wallen, G. R., Ulrich, C., & Grady, C. (2005). Learning about a “Good Death”: Ethical considerations in palliative care nursing research. DNA Reporter, 30(2), 8–9.
43.
Zurück zum Zitat Wills, T. A., & Shinar, O. (2000). Measuring perceived and received social support. In S. Cohen, L. G. Underwood, & B. H. Gottlieb (Eds.), Social support measurement and intervention: A guide for health and social scientists (pp. 86–135). New York: Oxford University Press. Wills, T. A., & Shinar, O. (2000). Measuring perceived and received social support. In S. Cohen, L. G. Underwood, & B. H. Gottlieb (Eds.), Social support measurement and intervention: A guide for health and social scientists (pp. 86–135). New York: Oxford University Press.
Metadaten
Titel
Palliative care outcomes in surgical oncology patients with advanced malignancies: a mixed methods approach
verfasst von
Gwenyth R. Wallen
Karen Baker
Marilyn Stolar
Claiborne Miller-Davis
Nancy Ames
Jan Yates
Jacques Bolle
Donna Pereira
Diane St. Germain
Daniel Handel
Ann Berger
Publikationsdatum
01.04.2012
Verlag
Springer Netherlands
Erschienen in
Quality of Life Research / Ausgabe 3/2012
Print ISSN: 0962-9343
Elektronische ISSN: 1573-2649
DOI
https://doi.org/10.1007/s11136-011-0065-7

Weitere Artikel der Ausgabe 3/2012

Quality of Life Research 3/2012 Zur Ausgabe