nach oben

Quality of Life Research

Erschienen in:

14.11.2015 | Review

Quality of life among patients after bilateral prophylactic mastectomy: a systematic review of patient-reported outcomes

Erschienen in: Quality of Life Research | Ausgabe 6/2016

Einloggen, um Zugang zu erhalten

Abstract

Purpose

Bilateral prophylactic mastectomy (BPM) is effective in reducing the risk of breast cancer in women with a well-defined family history of breast cancer or in women with BRCA 1 or 2 mutations. Evaluating patient-reported outcomes following BPM are thus essential for evaluating success of BPM from patient’s perspective. Our systematic review aimed to: (1) identify studies describing health-related quality of life (HRQOL) in patients following BPM with or without reconstruction; (2) assess the effect of BPM with or without reconstruction on HRQOL; and (3) identify predictors of HRQOL post-BPM.

Methods

We performed a systematic review of literature using the PRISMA guidelines. PubMed, Embase, PsycINFO, Web of Science, Scopus and Cochrane databases were searched.

Results

The initial search resulted in 1082 studies; 22 of these studies fulfilled our inclusion criteria. Post-BPM, patients are satisfied with the outcomes and report high psychosocial well-being and positive body image. Sexual well-being and somatosensory function are most negatively affected. Vulnerability, psychological distress and preoperative cancer distress are significant negative predictors of quality of life and body image post-BPM.

Conclusion

There is a paucity of high-quality data on outcomes of different HRQOL domains post-BPM. Future studies should strive to use validated and breast-specific PRO instruments for measuring HRQOL. This will facilitate shared decision-making by enabling surgeons to provide evidence-based answers to women contemplating BPM.

Giuliano, A. E., Boolbol, S., Degnim, A., Kuerer, H., Leitch, A. M., & Morrow, M. (2007). Society of Surgical oncology: Position statement on prophylactic mastectomy. Annals of Surgical Oncology, 14(9), 2425–2427.CrossRefPubMed

Chen, S., & Parmigiani, G. (2007). Meta-analysis of BRCA1 and BRCA2 penetrance. Journal of Clinical Oncology, 25(11), 1329–1333.CrossRefPubMedPubMedCentral

Antoniou, A., Pharoah, P. D., Narod, S., Risch, H. A., Eyfjord, J. E., Hopper, J. L., et al. (2003). Average risks of breast and ovarian cancer associated with BRCA1 or BRCA2 mutations detected in case series unselected for family history: A combined analysis of 22 studies. American Journal of Human Genetics, 72(5), 1117–1130.CrossRefPubMedPubMedCentral

Hartmann, L. C., Schaid, D. J., Woods, J. E., Crotty, T. P., Myers, J. L., Arnold, P. G., et al. (1999). Efficacy of bilateral prophylactic mastectomy in women with a family history of breast cancer. New England Journal of Medicine, 340(2), 77–84.CrossRefPubMed

Domchek, S. M., Friebel, T. M., Singer, C. F., Evans, D. G., Lynch, H. T., Isaacs, C., et al. (2010). Association of risk-reducing surgery in BRCA1 or BRCA2 mutation carriers with cancer risk and mortality. Journal of the American Medical Association, 304(9), 967–975.CrossRefPubMedPubMedCentral

Rebbeck, T. R., Friebel, T., Lynch, H. T., Neuhausen, S. L., van ‘t Veer, L., Garber, J. E., et al. (2004). Bilateral prophylactic mastectomy reduces breast cancer risk in BRCA1 and BRCA2 mutation carriers: The PROSE Study Group. Journal of Clinical Oncology, 22(6), 1055–1062.CrossRefPubMed

Meijers-Heijboer, H., van Geel, B., van Putten, W. L., Henzen-Logmans, S. C., Seynaeve, C., Menke-Pluymers, M. B., et al. (2001). Breast cancer after prophylactic bilateral mastectomy in women with a BRCA 1 or BRCA 2 mutation. New England Journal of Medicine, 345(3), 159–164.CrossRefPubMed

Liberati, A., Altman, D. G., Tetzlaff, J., Mulrow, C., Gøtzsche, P. C., Ioannidis, J. P., et al. (2009). The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate health care interventions: Explanation and elaboration. Journal of Clinical Epidemiology, 62(10), e1–34.CrossRefPubMed

Booth, A., Clarke, M., Dooley, G., Ghersi, D., Moher, D., Petticrew, M., et al. (2012). The nuts and bolts of PROSPERO: An international prospective register of systematic reviews. Systematic Reviews, 1, 2.CrossRefPubMedPubMedCentral

10.

Chen, C. M., Cano, S. J., Klassen, A. F., King, T., McCarthy, C., Cordeiro, P. G., et al. (2010). Measuring quality of life in oncologic breast surgery: A systematic review of patient-reported outcome measures. Breast Journal, 16(6), 587–597.CrossRefPubMed

11.

Slim, K., Nini, E., Forestier, D., Kwiatkowski, F., Panis, Y., & Chipponi, J. (2003). Methodological index for non-randomized studies (minors): Development and validation of a new instrument. ANZ Journal of Surgery, 73(9), 712–716.CrossRefPubMed

12.

Stefanek, M. E., Helzlsouer, K. J., Wilcox, P. M., & Houn, F. (1995). Predictors of and satisfaction with bilateral prophylactic mastectomy. Preventive Medicine, 24(4), 412–419.CrossRefPubMed

13.

Borgen, P. I., Hill, A. D., Tran, K. N., Van Zee, K. J., Massie, M. J., Payne, D., et al. (1998). Patient regrets after bilateral prophylactic mastectomy. Annals of Surgical Oncology, 5(7), 603–606.CrossRefPubMed

14.

Frost, M. H., Schaid, D. J., Sellers, T. A., Slezak, J. M., Arnold, P. G., Woods, J. E., et al. (2000). Long-term satisfaction and psychological and social function following bilateral prophylactic mastectomy. Journal of the American Medical Association, 284(3), 319–324.CrossRefPubMed

15.

Hatcher, M. B., Fallowfield, L., & A’Hern, R. (2001). The psychosocial impact of bilateral prophylactic mastectomy: Prospective study using questionnaires and semistructured interviews. British Medical Journal, 322(7278), 76.CrossRefPubMedPubMedCentral

16.

Metcalfe, K. A., Esplen, M. J., Goel, V., & Narod, S. A. (2004). Psychosocial functioning in women who have undergone bilateral prophylactic mastectomy. Psychooncology, 13(1), 14–25.CrossRefPubMed

17.

Metcalfe, K. A., Semple, J. L., & Narod, S. A. (2004). Satisfaction with breast reconstruction in women with bilateral prophylactic mastectomy: A descriptive study. Plastic and Reconstructive Surgery, 114(2), 360–366.CrossRefPubMed

18.

Contant, C. M. E., van Wersch, A. M. E., Menke-Pluymers, M. B. E., Wai, R. T. J., Eggermont, A. M. M., & Van Geel, A. N. (2004). Satisfaction and prosthesis related complaints in women with immediate breast reconstruction following prophylactic and oncological mastectomy. Psychology, Health and Medicine, 9(1), 71–84.CrossRef

19.

Metcalfe, K. A., Esplen, M. J., Goel, V., & Narod, S. A. (2005). Predictors of quality of life in women with a bilateral prophylactic mastectomy. Breast Journal, 11(1), 65–69.CrossRefPubMed

20.

Geiger, A. M., Nekhlyudov, L., Herrinton, L. J., Rolnick, S. J., Greene, S. M., West, C. N., et al. (2007). Quality of life after bilateral prophylactic mastectomy. Annals of Surgical Oncology, 14(2), 686–694.CrossRefPubMed

21.

Gahm, J., Jurell, G., Wickman, M., & Hansson, P. (2007). Sensitivity after bilateral prophylactic mastectomy and immediate reconstruction. Scandinavian Journal of Plastic and Reconstructive Surgery and Hand Surgery, 41(4), 178–183.CrossRefPubMed

22.

Spear, S. L., Schwarz, K. A., Venturi, M. L., Barbosa, T., & Al-Attar, A. (2008). Prophylactic mastectomy and reconstruction: Clinical outcomes and patient satisfaction. Plastic and Reconstructive Surgery, 122(1), 1–9.CrossRefPubMed

23.

Brandberg, Y., Sandelin, K., Erikson, S., Jurell, G., Liljegren, A., Lindblom, A., et al. (2008). Psychological reactions, quality of life, and body image after bilateral prophylactic mastectomy in women at high risk for breast cancer: A prospective 1-year follow-up study. Journal of Clinical Oncology, 26(24), 3943–3949.CrossRefPubMed

24.

Isern, A. E., Tengrup, I., Loman, N., Olsson, H., & Ringberg, A. (2008). Aesthetic outcome, patient satisfaction, and health-related quality of life in women at high risk undergoing prophylactic mastectomy and immediate breast reconstruction. Journal of Plastic and Reconstructive Aesthetic Surgery, 61(10), 1177–1187.CrossRef

25.

Gahm, J., Jurell, G., Edsander-Nord, A., & Wickman, M. (2010). Patient satisfaction with aesthetic outcome after bilateral prophylactic mastectomy and immediate reconstruction with implants. Journal of Plastic and Reconstructive Aesthetic Surgery, 63(2), 332–338.CrossRef

26.

Gahm, J., Edsander-Nord, A., Jurell, G., & Wickman, M. (2010). No differences in aesthetic outcome or patient satisfaction between anatomically shaped and round expandable implants in bilateral breast reconstructions: A randomized study. Plastic and Reconstructive Surgery, 126(5), 1419–1427.CrossRefPubMed

27.

Gahm, J., Wickman, M., & Brandberg, Y. (2010). Bilateral prophylactic mastectomy in women with inherited risk of breast cancer—prevalence of pain and discomfort, impact on sexuality, quality of life and feelings of regret two years after surgery. Breast, 19(6), 462–469.CrossRefPubMed

28.

Brandberg, Y., Arver, B., Johansson, H., Wickman, M., Sandelin, K., & Liljegren, A. (2012). Less correspondence between expectations before and cosmetic results after risk-reducing mastectomy in women who are mutation carriers: A prospective study. European Journal of Surgical Oncology, 38(1), 38–43.CrossRefPubMed

29.

Sahin, I., Isik, S., Alhan, D., Yildiz, R., Aykan, A., & Ozturk, E. (2013). One-staged silicone implant breast reconstruction following bilateral nipple-sparing prophylactic mastectomy in patients at high-risk for breast cancer. Aesthetic Plastic Surgery, 37(2), 303–311.CrossRefPubMed

30.

Eltahir, Y., Werners, L. L., Dreise, M. M., van Emmichoven, I. A., Jansen, L., Werker, P. M., et al. (2013). Quality-of-life outcomes between mastectomy alone and breast reconstruction: Comparison of patient-reported BREAST-Q and other health-related quality-of-life measures. Plastic and Reconstructive Surgery, 132(2), 201e–209e.CrossRefPubMed

31.

Gopie, J. P., Mureau, M. A., Seynaeve, C., Ter Kuile, M. M., Menke-Pluymers, M. B., Timman, R., et al. (2013). Body image issues after bilateral prophylactic mastectomy with breast reconstruction in healthy women at risk for hereditary breast cancer. Familial Cancer, 12(3), 479–487.CrossRefPubMed

32.

Gahm, J., Hansson, P., Brandberg, Y., & Wickman, M. (2013). Breast sensibility after bilateral risk-reducing mastectomy and immediate breast reconstruction: A prospective study. Journal of Plastic and Reconstructive Aesthetic Surgery, 66(11), 1521–1527.CrossRef

33.

Hagen, A. I., Maehle, L., Veda, N., Vetti, H. H., Stormorken, A., Ludvigsen, T., et al. (2014). Risk reducing mastectomy, breast reconstruction and patient satisfaction in Norwegian BRCA1/2 mutation carriers. Breast, 23(1), 38–43.CrossRefPubMed

34.

Agarwal, S., Pappas, L., Neumayer, L., Kokeny, K., & Agarwal, J. (2014). Effect of breast conservation therapy vs mastectomy on disease-specific survival for early-stage breast cancer. JAMA Surgery, 149(3), 267–274.CrossRefPubMed

35.

Pusic, A. L., Klassen, A. F., Scott, A. M., Klok, J. A., Cordeiro, P. G., & Cano, S. J. (2009). Development of a new patient-reported outcome measure for breast surgery: The BREAST-Q. Plastic and Reconstructive Surgery, 124(2), 345–353.CrossRefPubMed

Titel: Quality of life among patients after bilateral prophylactic mastectomy: a systematic review of patient-reported outcomes
Publikationsdatum: 14.11.2015
Erschienen in: Quality of Life Research / Ausgabe 6/2016
Print ISSN: 0962-9343
Elektronische ISSN: 1573-2649
DOI: https://doi.org/10.1007/s11136-015-1181-6

Springer Medizin

Abstract

Purpose

Methods

Results

Conclusion

Bitte loggen Sie sich ein, um Zugang zu diesem Inhalt zu erhalten

Weitere Artikel der Ausgabe 6/2016

Validation of the EORTC QLQ-INFO 25 questionnaire in Lebanese cancer patients: Is ignorance a Bliss?

Obesity, metabolic abnormality, and health-related quality of life by gender: a cross-sectional study in Korean adults

Using structural equation modeling to detect response shifts and true change in discrete variables: an application to the items of the SF-36

Cardiff cardiac ablation patient-reported outcome measure (C-CAP): validation of a new questionnaire set for patients undergoing catheter ablation for cardiac arrhythmias in the UK

Quality of life across medical conditions and psychological factors: implications for population health management

Validity, responsiveness, and minimal clinically important difference of EQ-5D-5L in stroke patients undergoing rehabilitation