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Erschienen in: International Urology and Nephrology 4/2013

01.08.2013 | Nephrology - Original Paper

Oxidative stress in patients treated with continuous ambulatory peritoneal dialysis (CAPD) and the significant role of vitamin C and E supplementation

verfasst von: Georgios Boudouris, Ioannis I. Verginadis, Yannis V. Simos, Andreas Zouridakis, Vasilios Ragos, Spyridon Ch. Karkabounas, Angelos M. Evangelou

Erschienen in: International Urology and Nephrology | Ausgabe 4/2013

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Abstract

Purpose

Chronic renal failure patients undergoing peritoneal dialysis (PD) are characterized by increased oxidative stress (OS), which is associated with enhanced cardiovascular risk. Moreover, oxidative stress also contributes to peritoneal membrane changes and ultrafiltration failure. The aim of this study was to evaluate OS in PD patients and the effect of treatment with ascorbic acid and α-tocopherol.

Methods

Plasma, erythrocyte, urine, and peritoneal effluent samples from 20 patients on PD were evaluated for glutathione peroxidase and superoxide dismutase activity, total antioxidant capacity (TAC) and malondialdehyde (MDA) levels, as well as protein carbonyl formation, before and after administration of vitamin C, alone or in combination with vitamin E, in comparison with 10 apparently healthy control individuals.

Results

All studied markers showed enhanced OS in the PD group, compared to controls. The supplementation of vitamin C and E resulted in improvements of all the OS markers, as indicated by increased erythrocyte antioxidant enzymes activity and TAC levels, as well as decreased MDA concentration and carbonyl compound formation.

Conclusions

The oral supplementation of antioxidant vitamins C and E, in combination, can lead to decreased OS, thus providing a useful and cost-effective therapeutic option in PD patients.
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Metadaten
Titel
Oxidative stress in patients treated with continuous ambulatory peritoneal dialysis (CAPD) and the significant role of vitamin C and E supplementation
verfasst von
Georgios Boudouris
Ioannis I. Verginadis
Yannis V. Simos
Andreas Zouridakis
Vasilios Ragos
Spyridon Ch. Karkabounas
Angelos M. Evangelou
Publikationsdatum
01.08.2013
Verlag
Springer Netherlands
Erschienen in
International Urology and Nephrology / Ausgabe 4/2013
Print ISSN: 0301-1623
Elektronische ISSN: 1573-2584
DOI
https://doi.org/10.1007/s11255-012-0334-6

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