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Erschienen in: International Urology and Nephrology 3/2016

01.03.2016 | Nephrology - Original Paper

Effect of restricted protein diet supplemented with keto analogues in chronic kidney disease: a systematic review and meta-analysis

verfasst von: Zheng Jiang, Xiaoyan Zhang, Lichuan Yang, Zi Li, Wei Qin

Erschienen in: International Urology and Nephrology | Ausgabe 3/2016

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Abstract

Background

To evaluate the efficacy and safety of the restricted protein diet (low or very low protein diet) supplemented with keto analogues in the treatment of chronic kidney disease (CKD).

Methods

The Cochrane library, PubMed, Embase, CBM and CENTRAL databases were searched and reviewed up to April 2015. Clinical trials were analyzed using RevMan 5.3 software.

Results

Seven random control trials, one cross-over trial and one non-randomized concurrent control trial were selected and included in this study according to our inclusion and exclusion criteria. The changes of eGFR, BUN, Scr, albumin, PTH, triglyceride, cholesterol, calcium, phosphorus and nutrition indexes (BMI, lean body mass and mid-arm muscular circumference) before and after treatment were analyzed. The meta-analysis results indicated that, comparing with normal protein diet, low protein diet (LPD) or very low protein diet (vLPD) supplemented with keto analogues (s(v)LPD) could significantly prevent the deterioration of eGFR (P < 0.001), hyperparathyroidism (P = 0.04), hypertension (P < 0.01) and hyperphosphatemia (P < 0.001). No differences in BUN, Scr, Albumin, triglyceride, cholesterol, hemoglobin, calcium and nutrition indexes were observed between different protein intake groups.

Conclusion

Restricted protein diet supplemented with keto analogues (s(v)LPD) could delay the progression of CKD effectively without causing malnutrition.
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Metadaten
Titel
Effect of restricted protein diet supplemented with keto analogues in chronic kidney disease: a systematic review and meta-analysis
verfasst von
Zheng Jiang
Xiaoyan Zhang
Lichuan Yang
Zi Li
Wei Qin
Publikationsdatum
01.03.2016
Verlag
Springer Netherlands
Erschienen in
International Urology and Nephrology / Ausgabe 3/2016
Print ISSN: 0301-1623
Elektronische ISSN: 1573-2584
DOI
https://doi.org/10.1007/s11255-015-1170-2

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